Magnetic resonance imaging in the prenatal diagnosis of congenital diarrhea

Colombani, Marina; Ferry, M.; Toga, C.; Lacroze, V.; Rubesova, Erika; Barth, Richard A.; Cassart, Marie; Gorincour, G.

doi:10.1002/uog.7509

Cited by 30 publications

(17 citation statements)

References 13 publications

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“…Fetal bowel loop dilatation is an uncommon finding that has been related to several conditions and is generally divided into obstructive and nonobstructive types . In most cases, prenatal bowel dilatation usually suggests an obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…Nonobstructive bowel dilatation is a rare entity and may be the result of intrauterine fetal compromise, congenital chloride diarrhea, Hirschsprung disease, congenital pseudoobstruction, and microvillous inclusion disease. Prenatal diagnosis is difficult and may consist of diffuse dilated bowel loops, polyhydramnios, and echogenic bowel . Microvillous inclusion disease is a fatal congenital disorder of the intestine.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the data in the literature refer to obstructive bowel disease, which includes congenital intestinal atresia, volvulus and malrotation, cystic fibrosis, and meconium ileus. Scarce data exist in the literature on nonobstructive bowel dilatation, and only a few cases have been reported on congenital chloride diarrhea, congenital pseudoobstruction, fetal compromise, and Hirschsprung disease …”

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confidence: 99%

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Nonobstructive Diffuse Dilated Bowel Loops: Prenatal Diagnosis, Fetal Characteristics and Neonatal Outcomes

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Nonobstructive Diffuse Dilated Bowel Loops: Prenatal Diagnosis, Fetal Characteristics and Neonatal Outcomes

et al. 2016

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“…Normally, meconium within the bowel is hyperintense on T1-weighted images. With CCD, hyperintensity within the bowel is absent due to watery diarrhea [14]. In this case, we carried out MRI with 1.5T system MAGNETOM Symphony (Siemens Healthcare, Germany) as an adjunct to ultrasonography.…”

Section: Discussionmentioning

confidence: 99%

“…With CCD, the Cl level in amniotic fluid rises, but this does not provide a definitive diagnosis [13]. In recent years, Colombani et al reported that MRI in addition to ultrasound findings helped to diagnose the condition [14]. …”

Section: Introductionmentioning

confidence: 99%

Congenital Chloride Diarrhea (CCD): A Case Report of CCD Suspected by Prenatal Ultrasonography and Magnetic Resonance Imaging (MRI)

Kawamura

Nishiguchi

2017

Am J Case Rep

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Patient: Male, new bornFinal Diagnosis: Congenital chloride diarrheaSymptoms: DiarrheaMedication: —Clinical Procedure: —Specialty: Obstetrics and GyneolcogyObjective:Congenital defects/diseasesBackground:Congenital chloride diarrhea (CCD) is a rare autosomal recessive disorder that is difficult to distinguish from fetal lower intestinal obstruction. A prenatal diagnosis will make a contribution to the prognosis of the newborn.Case Report:We report a rare case of congenital chloride diarrhea (CCD) prenatally suspected by ultrasound and MRI. The prenatal ultrasound revealed signs of intestinal dilatation suggesting lower intestinal obstruction. MRI findings also revealed intestinal dilatation that continued from the rectum. On T1-weighted images, fluid accumulation within the bowel was hypointense. CCD was strongly suspected rather than obstruction of the lower intestinal tract or Hirschsprung’s disease. At 37 weeks and 3 days’ gestation, cesarean section was performed because of fetal distress. The newborn was a 2396 g male with the Apgar scores 8 (1 min) and 9 (5 min). Watery diarrhea subsequently persisted, and on the 3rd day, hyponatremia and hypochloremia were present. The infant stool was hyperchloremic, so we diagnosed CCD.Conclusions:When ultrasonography reveals signs of fetal gastrointestinal dilatation, lower intestinal obstruction is considered first. CCD is infrequent and has signs of intestinal dilatation similar to those of other intestinal ailments, so distinguishing these conditions is difficult. However, if CCD is suspected early, then use of MRI will allow its diagnosis. If the condition is diagnosed before birth, the prognosis of the newborn will improve.

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Prenatal diagnosis and management of congenital chloride diarrhea: A case report of 2 siblings

Imada

Kikuchi

Horikoshi

et al. 2012

J of Clinical Ultrasound

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Congenital chloride diarrhea (CLD) is a rare hereditary disease. The basic defect of CLD is massive loss of Cl(-) and fluid into the ileum and colon. Prenatal diagnosis of this disease is quite important because the infant requires electrolyte supplementation from the early postnatal period. Two cases in which prenatal diagnoses of CLD were made in siblings are reported. Extreme electrolyte imbalance may cause fetal cardiac dysfunction or a poor general condition leading to a non-reassuring fetal status in cases with CLD. Therefore, frequent fetal monitoring using cardiotocograms and ultrasound may be beneficial to some fetuses with CLD to detect fetal deterioration. In addition, repeated amnioreduction may be required to treat severe polyhydramnios and threatened preterm delivery.

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Magnetic resonance imaging in the prenatal diagnosis of congenital diarrhea

Abstract: Objective

Cited by 30 publications

References 13 publications

Nonobstructive Diffuse Dilated Bowel Loops: Prenatal Diagnosis, Fetal Characteristics and Neonatal Outcomes

Nonobstructive Diffuse Dilated Bowel Loops: Prenatal Diagnosis, Fetal Characteristics and Neonatal Outcomes

Congenital Chloride Diarrhea (CCD): A Case Report of CCD Suspected by Prenatal Ultrasonography and Magnetic Resonance Imaging (MRI)

Prenatal diagnosis and management of congenital chloride diarrhea: A case report of 2 siblings

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