Magnetic resonance imaging in the management of Crohn’s disease: a systematic review and meta-analysis

Ahmad, Rani; Ajlan, Amr M.; Eskander, Ayman A.; Alhazmi, Turki; Khashoggi, Khalid; Wazzan, Mohammad; Abduljabbar, Ahmed

doi:10.1186/s13244-021-01064-9

Cited by 13 publications

(8 citation statements)

References 54 publications

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“…In CD patients magnetic resonance enterography (MRE) is an essential pillar for diagnosis, assessment of disease severity, and complications (outside the acute setting) [ 15 ]. Its advantages included the avoidance of radiation exposure and good diagnostic accuracy [ 16 ]. So far, the quantification of body composition parameters in CD has been mainly performed on computer tomography (CT) scans [ 4 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Body Composition Predictors of Complicated Crohn’s Disease

Ordonez

Melekh

Rodríguez-Feria

et al. 2023

Dig Dis

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Background: High visceral adipose tissue (VAT) and creeping fat (CrF) in Crohn's disease (CD) have been widely recognized. The VAT to subcutaneous adipose tissue (SAT) ratio and sarcopenia have been associated with CD complications. Studies regarding the influence of body composition predictors on CD complications assessed with magnetic resonance enterography (MRE) are scarce. Aim: Assessment of the body composition parameters and CrF in opportunistic MRE as predictors of complicated CD. Methods: This was a retrospective study of 114 patients with inflammatory (n = 54) and complicated (n = 60) CD. The semi-automated assessment of body composition and the qualitative evaluation of CrF were performed. Results: Body composition parameters did not differ between both groups regarding the body mass index (BMI) (p =0.50), total adipose tissue index (TATI) (p =0.14), subcutaneous adipose tissue index (SATI) (p =0.17), visceral adipose tissue index (VATI) (p =0.33), VAT/SAT ratio (p =0.77), intramuscular adipose tissue (IMAT) (p =0.64), skeletal muscle index (SMI) (p =0.22), and sarcopenia (p =0.50). 47 strictures, 18 fistulae, and seven abscesses were identified. Fistulae were more likely to occur in patients with CrF (odds ratio [OR] 5.07, 95% confidence interval [CI] 1.76–14.56; p=<0.001) and high VAT/SAT ratio (OR: 3.82, 95% CI 1.34–10.85; p=0.01). Conclusion: Body composition measurements in CD patients displayed no statistically significant difference between the groups of inflammatory and complicated disease. Nonetheless, CD patients stratified in the group of high VAT/SAT ratio and the presence of CrF should be recognized as risk groups for the occurrence of fistulae.

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Section: Introductionmentioning

confidence: 99%

Body Composition Predictors of Complicated Crohn’s Disease

Ordonez

Melekh

Rodríguez-Feria

et al. 2023

Dig Dis

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“…For all the considerations above, MRI has gained significant traction in the last decade, proving a higher degree of sensitivity in detecting small bowel activity of CD, as well as limiting the radiation exposure [176]. In addition, MRI has a higher sensitivity in detecting transmural fibrosis as well as in highlighting early clinical responses [177,178].…”

Section: Imaging Methods In Inflammatory Bowel Diseasesmentioning

confidence: 99%

Recent Trends in Non-Invasive Methods of Diagnosis and Evaluation of Inflammatory Bowel Disease: A Short Review

Vălean,

Zaharie,

Țaulean

et al. 2024

IJMS

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Inflammatory bowel diseases are a conglomerate of disorders causing inflammation of the gastrointestinal tract, which have gained a significant increase in prevalence in the 21st century. As they present a challenge in the terms of diagnosis as well as treatment, IBDs can present an overwhelming impact on the individual and can take a toll on healthcare costs. Thus, a quick and precise diagnosis is required in order to prevent the high number of complications that can arise from a late diagnosis as well as a misdiagnosis. Although endoscopy remains the primary method of evaluation for IBD, recent trends have highlighted various non-invasive methods of diagnosis as well as reevaluating previous ones. This review focused on the current non-invasive methods in the diagnosis of IBD, exploring their possible implementation in the near future, with the goal of achieving earlier, feasible, and cheap methods of diagnosis as well as prognosis in IBD.

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“…Twenty-two reviews (5,6,10,(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38) were rated as moderate in quality, and twenty-three reviews (39-60) were rated as low, while one review (61) was rated as critically low in quality (Supplementary Appendix 9). In the seven critical domains, most low-quality reviews had not stated that the methods were established before conducting the study.…”

Section: Methodological Qualitymentioning

confidence: 99%

Diagnostic Utility of Non-invasive Tests for Inflammatory Bowel Disease: An Umbrella Review

et al. 2022

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BackgroundThis study aims to consolidate evidence from published systematic reviews and meta-analyses evaluating the diagnostic performances of non-invasive tests for inflammatory bowel disease (IBD) in various clinical conditions and age groups.MethodsTwo independent reviewers systematically identified and appraised systematic reviews and meta-analyses assessing the diagnostic utility of non-invasive tests for IBD. Each association was categorized as adults, children, and mixed population, based on the age ranges of patients included in the primary studies. We classified clinical scenarios into diagnosis, activity assessment, and predicting recurrence.ResultsIn total, 106 assessments from 43 reviews were included, with 17 non-invasive tests. Fecal calprotectin (FC) and fecal lactoferrin (FL) were the most sensitive for distinguishing IBD from non-IBD. However, anti-neutrophil cytoplasmic antibodies (ANCA) and FL were the most specific for it. FC and FL were the most sensitive and specific tests, respectively, to distinguish IBD from irritable bowel syndrome (IBS). Anti-Saccharomyces cerevisiae antibodies (ASCA), IgA, were the best test to distinguish Crohn’s disease (CD) from ulcerative colitis (UC). Interferon-γ release assay was the best test to distinguish CD from intestinal tuberculosis (ITB). Ultrasound (US) and magnetic resonance enterography (MRE) were both sensitive and specific for disease activity, along with the high sensitivity of FC. Small intestine contrast ultrasonography (SICUS) had the highest sensitivity, and FC had the highest specificity for operative CD recurrence.ConclusionIn this umbrella review, we summarized the diagnostic performance of non-invasive tests for IBD in various clinical conditions and age groups. Clinicians can use the suggested non-invasive test depending on the appropriate clinical situation in IBD patients.

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Magnetic resonance imaging in the management of Crohn’s disease: a systematic review and meta-analysis

Cited by 13 publications

References 54 publications

Body Composition Predictors of Complicated Crohn’s Disease

Body Composition Predictors of Complicated Crohn’s Disease

Recent Trends in Non-Invasive Methods of Diagnosis and Evaluation of Inflammatory Bowel Disease: A Short Review

Diagnostic Utility of Non-invasive Tests for Inflammatory Bowel Disease: An Umbrella Review

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