Magnetic resonance imaging is an accurate and reliable method to evaluate non‐cystic fibrosis paediatric lung disease

Montella, Silvia; Maglione, Marco; Bruzzese, Dario; Mollica, Carmine; Pignata, Claudio; Aloj, Giuseppina; Manna, Angelo; Esposito, Antonietta; Mirra, Virginia; Santamaria, Francesca

doi:10.1111/j.1440-1843.2011.02067.x

Cited by 58 publications

(44 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar to CF, chest CT scanning is more accurate to assess early PCD lung disease compared with spirometric indices (38). Chest high field 3T magnetic resonance imaging appears to be as effective as high-resolution chest CT in assessing the extent and severity of lung abnormalities in PCD, making this radiation-free imaging technique an intriguing option for longitudinal assessment and research studies (43).…”

Section: Lung Imagingmentioning

confidence: 99%

Primary Ciliary Dyskinesia. Recent Advances in Diagnostics, Genetics, and Characterization of Clinical Disease

Knowles¹,

Daniels²,

Davis

et al. 2013

Am J Respir Crit Care Med

440

460

View full text Add to dashboard Cite

Primary ciliary dyskinesia (PCD) is a genetically heterogeneous recessive disorder of motile cilia that leads to oto-sino-pulmonary diseases and organ laterality defects in approximately 50% of cases. The estimated incidence of PCD is approximately 1 per 15,000 births, but the prevalence of PCD is difficult to determine, primarily because of limitations in diagnostic methods that focus on testing ciliary ultrastructure and function. Diagnostic capabilities have recently benefitted from (1) documentation of low nasal nitric oxide production in PCD and (2) discovery of biallelic mutations in multiple PCD-causing genes. The use of these complementary diagnostic approaches shows that at least 30% of patients with PCD have normal ciliary ultrastructure. More accurate identification of patients with PCD has also allowed definition of a strong clinical phenotype, which includes neonatal respiratory distress in .80% of cases, daily nasal congestion and wet cough starting soon after birth, and early development of recurrent/chronic middle-ear and sinus disease. Recent studies, using advanced imaging and pulmonary physiologic assessments, clearly demonstrate early onset of lung disease in PCD, with abnormal air flow mechanics by age 6-8 years that is similar to cystic fibrosis, and age-dependent onset of bronchiectasis. The treatment of PCD is not standardized, and there are no validated PCD-specific therapies. Most patients with PCD receive suboptimal management, which should include airway clearance, regular surveillance of pulmonary function and respiratory microbiology, and use of antibiotics targeted to pathogens. The PCD Foundation is developing a network of clinical centers, which should improve diagnosis and management of PCD.

show abstract

Section: Lung Imagingmentioning

confidence: 99%

Primary Ciliary Dyskinesia. Recent Advances in Diagnostics, Genetics, and Characterization of Clinical Disease

Knowles¹,

Daniels²,

Davis

et al. 2013

Am J Respir Crit Care Med

440

460

View full text Add to dashboard Cite

show abstract

“…Chest CT is more sensitive for detecting early lung disease in PCD, compared to lung function testing by spirometry (60). Magnetic resonance imaging of the chest may be as effective as chest CT in defining the extent and severity of lung disease in PCD, which is an intriguing option for longitudinal evaluation and research (65). …”

Section: Lung Diseasementioning

confidence: 99%

Primary Ciliary Dyskinesia

Knowles

Zariwala

Leigh

2016

Clinics in Chest Medicine

190

156

View full text Add to dashboard Cite

“…Ciliary motility disorders · Kartagener syndrome · Cilia · Respiratory tract infections · Pulmonary function test tik (Thorax-Röntgenaufnahme, Thorax-CT/MRT, CT/MRT der Nasennebenhöhlen) erfolgt abhängig von der Klinik unter Berücksichtigung des Strahlenschutzes [12,15] [3], die die Bedeutung der regelmäßi-gen Atemwegsreinigung mittels Physiotherapie und Inhalationstherapie, der konsequenten antibiotischen Behandlung von Atemwegsinfekten sowie der Vermeidung schädigender Faktoren wie aktives oder passives Rauchen betonen.…”

Section: Introductionunclassified

Primäre ziliäre Dyskinesie

Werner

Omran

2015

Pneumologe

View full text Add to dashboard Cite

Magnetic resonance imaging is an accurate and reliable method to evaluate non‐cystic fibrosis paediatric lung disease

Abstract: Chest MRI was equivalent to HRCT to determine the extent of lung disease in children with non-CF lung disease. The findings support the use of chest MRI as an alternative to HRCT in diagnostic pathways for paediatric chronic lung disorders.

Cited by 58 publications

References 31 publications

Primary Ciliary Dyskinesia. Recent Advances in Diagnostics, Genetics, and Characterization of Clinical Disease

Primary Ciliary Dyskinesia. Recent Advances in Diagnostics, Genetics, and Characterization of Clinical Disease

Primary Ciliary Dyskinesia

Primäre ziliäre Dyskinesie

Contact Info

Product

Resources

About