Magnetic Resonance Imaging (MRI) Findings in Epileptic Children and its Relation with Clinical and Demographic Findings

Amirsalari, Susan; Saburi, Amin; Hadi, Reza; Mirmohammad, S M

doi:10.1038/pr.2011.371

Cited by 11 publications

(21 citation statements)

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“…Cumulative incidence of epilepsy is 3 % all over the life and more than half of them are started since childhood period. 2 Epilepsy affects 0.5-1% of children and it is one of the most common chronic neurologic disorder among children. Incidence is higher in underdeveloped countries, when compared with developed countries.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging findings in newly diagnosed epileptic children

Dirik¹,

Şanlıdağ

2018

Pak J Med Sci

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Objectives:Epilepsy is one of the most common chronic neurologic disorders in childhood and it affects 0.5-1% of children. The purpose of the study was to determine the prevalence and types of structural abnormalities in the epileptic children.Methods:The study was performed in Near East University and Dr. Suat Gunsel University in North Cyprus. It was conducted at pediatric neurology outpatient clinic of the hospital. The records of 1 to 18 years old epileptic children in whom Magnetic Resonance Imaging (MRI) performed within 6 months after diagnosis were enrolled to the study between the dates of October 2011 and June 2017.Results:Among 220 children; 131 (59.55%) had no abnormality and 89 (45.45%) had at least one abnormality in the MRI. Most commonly documented lesions were generally encephalomalacia, hydrocephaly and brain atrophy with a percent of 5.90 (13 cases), 5.45 (12 cases) and 4.55 (10 cases) respectively. Sixty nine (31.06%) of the patients had one abnormality whereas 20 (9.09%) had two or more lesion.Conclusion:Abnormality in MRI examination in newly diagnosed epileptic children was high. These high rates may be due to enrollment of children with new emerging epilepsy on a chronical neurologic disorder. Additionally 20 (9.09%) of patients had a concomitant lesion. Secondary lesions were detected in cases with corpus callosum abnormality, atrophy, encephalomalacia and hydrocephaly. Primarily formed lesions are unknown; further studies are needed to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging findings in newly diagnosed epileptic children

Dirik¹,

Şanlıdağ

2018

Pak J Med Sci

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“…A similar study revealed abnormal MRI of brain in 28.50% of children. The abnormalities included brain atrophy (10%), leukoencephalopathy (8%), benign cysts (5%), brain tumors (4%) and vascular abnormalities (1.50%) [14]. In the present study, the MRI abnormalities included atrophy in 58 (40.27%); signal alterations in 61 (42.36%) and ventriculomegaly in 29 (20.13%) patients.…”

Section: Discussionmentioning

confidence: 44%

MRI observations in children with epilepsy: experience from a large cohort

et al. 2015

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We analyzed the magnetic resonance imaging (MRI) observations and their clinical correlates in a large cohort of children with epilepsy. This observational study prospectively included 144 children with epilepsy (male/female = 73/71; mean age = 5.87 ? 4.19 yr duration = 2.74 ? 2.79 yr), who were evaluated with cranial MRI and phenotypic data. The seizures types were partial 67; generalized 72, and unclassified five. Ninety-four (65.28%) patients had abnormal MRI findings. The common MRI findings included atrophy in 58 [diffuse 33; focal 25]; signal changes in 61 [T2-weighted hyperintense with T1-weighted hypointense to isointense in 58; T1-weighted hyperintense in two patients T2-weighted hypointense in one]; and ventriculomegaly in 29. Among 41 children with both computerized tomography and MRI of brain, 10 were normal, while MRI had better delineation in 17 children and concordant in rest 14. Electroencephalography was abnormal in 104 (72.22%). The syndromic subtypes were structural/metabolic (symptomatic) in 95 (acute in eight); unknown (cryptogenic) in 45; and genetic (idiopathic) in six patients. Based on the imaging and other electroclinical features the final diagnosis in the symptomatic subgroup were hypoxic ischemic encephalopathy in 27; developmental malformation in 14; poliodystrophy in 13; leukoencephalopathy in seven; granuloma in seven; tumor in four; ischemic in three; meningoencephalitis in three; Rasmussen?s encephalitis in three; progressive cerebral degeneration in three; chromosomal in two; neurocutaneous in two; developmental in two; and metabolic; gliosis; storage, hippocampal sclerosis, calcification in one each cases. Seizure freedom for >1 yr was noted in 50%.

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“…(5,21) Amirsalari et al in their cross-sectional study of 200 Iranian epileptic children reported predominance of focal seizures than generalised seizures. (26) Focal seizures constituted 79% of the seizure type in the study by Wongladarom et al (24) Epileptic syndromes were observed in only 10 patients (12.5%), whereas Dura Trave et al reported high prevalence of the same. (27) Two cases, each of BECTS, CAE, Dravet Syndrome and four cases of Lennox-Gastaut Syndrome were present with normal MRI in three cases.…”

Section: Discussionmentioning

confidence: 90%

“…Amirsalari et al reported positive family history in 56.5% and this series had only in 20%. (26) 43% had a history of status epilepticus, either during presentation or later. Study by Berg et al in 613 American children showed status epilepticus in as little as 9.1%.…”

Section: Discussionmentioning

confidence: 99%

A Study on Magnetic Resonance Imaging Findings in Childhood Epilepsy

K¹,

Alikunju²

2018

jemds

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BACKGROUND Epilepsy is the most common brain disorder during childhood and it may be associated with serious conditions. Early recognition and treatment is essential for best possible outcome. MRI is the modality of choice for investigating epilepsy to detect the underlying aetiology. Different imaging techniques are available that can provide high levels of anatomical and metabolic data. MRI is an important tool in the assessment of children with inborn errors of metabolism.The objective of this study is to study the prevalence of MRI findings and to evaluate the role of MRI in diagnosis and management of childhood epilepsy. The study also aims to compare MRI findings in children having normal neurological examination with those having the specified abnormalities. The clinical and EEG predictors of abnormal MRI were also identified. MATERIALS AND METHODSA total of 80 children between 2 -14 years were admitted with history of seizure (other than symptomatic and febrile seizures) subjected to MRI and EEG were included. Data was obtained from observation and evaluation. Children were also grouped into two to compare MRI findings. The former with abnormal neurological examination and the latter having no neurological abnormalities. MRI and EEG findings were analysed using SPSS software version 18. Settings-Cross-sectional study was conducted in the Department of Paediatrics, Government Medical College, Thrissur, from January -December 2013. RESULTSMean age of the study population was estimated to be 7 years and that of the onset of seizures was 4.15 years. Abnormal MRI findings were found in 39 children (48.75%). 35% of children with normal examination and 62.5% with abnormal examination had abnormal MRI. The age of onset of seizures for children with abnormal MRI was significantly lower than that of those with normal MRI. The most common MRI abnormality detected was Malformations of Cortical Development. 74.3% of children with history of Status Epilepticus had abnormal MRI findings, which were statistically significant. Abnormal EEG was found in 52.5% of the population with 10% showing focal abnormalities. Ten patients (12.5%) were diagnosed with epileptic syndromes. CONCLUSIONMagnetic Resonance Imaging abnormalities are common among epileptic children with abnormal neurological examination. Children with lower age of onset and with status epilepticus showed more abnormalities. MRI helps in the management of children with underlying surgically amenable structural lesions.

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Magnetic Resonance Imaging (MRI) Findings in Epileptic Children and its Relation with Clinical and Demographic Findings

Cited by 11 publications

References 0 publications

Magnetic resonance imaging findings in newly diagnosed epileptic children

Magnetic resonance imaging findings in newly diagnosed epileptic children

MRI observations in children with epilepsy: experience from a large cohort

A Study on Magnetic Resonance Imaging Findings in Childhood Epilepsy

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