Magnetic resonance imaging of cartilaginous tumors: is it useful or necessary?

Lh, De Beuckeleer; Schepper, De; Ramon, F

doi:10.1007/s002560050050

Cited by 86 publications

(48 citation statements)

References 9 publications

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“…Geirnaerdt et al (17) demonstrated that septonodular and peripheral rim enhancement observed on Gd-enhanced MR images supported the diagnosis of a chondroblastic osteosarcoma. However, our results demonstrate that septonodular and peripheral rim enhancement patterns are characteristic patterns for chondroid matrix-forming tumors (21,22), not exclusively for chondroblastic osteosarcomas. Therefore, these findings in Gd-enhanced MR images are not useful for the differentiation of chondroblastic osteosarcoma from chondrosarcoma.…”

Section: Discussionmentioning

confidence: 48%

Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

Yakushiji

Oka

Sato

et al. 2009

Magnetic Resonance Imaging

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Purpose: To detect differences in magnetic resonance imaging (MRI) between chondroblastic osteosarcoma and the other types of osteosarcomas or chondrosarcomas using gadolinium-enhanced versus diffusion-weighted sequences. Materials and Methods:Contrast-enhanced MRI and diffusion-weighted imaging (DWI) were performed in five chondroblastic osteosarcoma (CO) cases, 17 other types of osteosarcomas (OS), and 18 chondrosarcomas (CS). DWI was obtained with a single-shot echo-planar imaging (EPI) sequence using a 1.5T MR imager. The apparent diffusion coefficients (ADCs) of the minimum and maximum values were also obtained. The contrast-enhancement pattern was evaluated and minimum-maximum ADC value of CO was compared with other types of OS and CS.Results: Both CO and CS showed a similar enhancement pattern; both showed septonodular and peripheral rim enhancement. The minimum ADC value of CO (1.24 Ϯ 0.10 ϫ 10 Ϫ3 mm 2 /sec) was significantly higher than that of other types of OS (0.84 Ϯ 0.15 ϫ 10 Ϫ3 mm 2 /sec) and was significantly lower than that of CS (1.64 Ϯ 0.20 ϫ 10 Ϫ3 mm 2 /sec). In addition, the maximum ADC value of CO (2.28 Ϯ 0.20 ϫ 10 Ϫ3 mm 2 /sec) was significantly higher than that of other types of OS (1.33 Ϯ 0.26 ϫ 10 Ϫ3 mm 2 /sec).Conclusion: DWI appears to be more useful for differentiating between chondroblastic osteosarcoma and chondrosarcoma or other types of osteosarcoma than Gd-enhanced MRI.

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Section: Discussionmentioning

confidence: 48%

Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

Yakushiji

Oka

Sato

et al. 2009

Magnetic Resonance Imaging

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“…This study on a rat model of grade II chondrosarcoma aimed to determine whether the radiotracer N-(triethylammonium)-3-propyl- [15]ane-N5 radiolabeled with 99m Tc ( 99m Tc-NTP , which binds to cartilage proteoglycans, has pathophysiologic validity for in vivo imaging of cartilage tumoral tissue. Methods: We used 2 experimental approaches with the Swarm chondrosarcoma rat model: that is, a primary paratibial location and local recurrence after intralesional curettage.…”

mentioning

confidence: 99%

First Preclinical Imaging of Primary Cartilage Neoplasm and Its Local Recurrence Using ^99mTc-NTP 15-5 Radiotracer

et al. 2009

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This study on a rat model of grade II chondrosarcoma aimed to determine whether the radiotracer N-(triethylammonium)-3-propyl- [15]ane-N5 radiolabeled with 99m Tc ( 99m Tc-NTP 15-5), which binds to cartilage proteoglycans, has pathophysiologic validity for in vivo imaging of cartilage tumoral tissue. Methods: We used 2 experimental approaches with the Swarm chondrosarcoma rat model: that is, a primary paratibial location and local recurrence after intralesional curettage. 99m Tc-NTP 15-5 scintigraphy and 99m Tc-hydroxymethylenediphosphonate ( 99m Tc-HMDP) scanning were performed at regular intervals during 50 d after tumor implantation in a paratibial location (primary model; n 5 12 animals) and after intralesional curettage in a femoral condyle location (recurrence model; n 5 9 animals). For each animal, positive scans were analyzed at each time point using the targetto-background ratio (TBR), with the target region of interest delineated over the tumor and the background region of interest over muscle. In each model, the TBR time course was followed against primary tumoral growth or recurrence. Tumor volume was monitored for 2 mo by measuring the 2 perpendicular diameters. At study end, animals were sacrificed for histopathologic analysis. Results: For both models, 99m Tc-NTP 15-5 scans showed tracer accumulation at the site of implantation or curettage. For the primary tumor model, the mean TBR was 1.6 6 0.14 by day 4 after implantation and increased over time as the disease progressed, with a mean TBR of 4.25 6 0.25 on day 45. For the recurrence model, mean TBR was 3.27 6 0.24 by day 4 after curettage and increased with recurrence, with a mean value of 5.25 6 0.49 on day 50. 99m Tc-HMDP bone scans were negative for both models throughout the study; at a later stage of the study, an area of 99m Tc-HMDP accumulation was seen in the diaphysis of the bone adjacent to the tumor and was attributed to remodeling. Conclusion: These experimental results in 2 preclinical models of grade II chondrosarcoma bring forward data in favor of 99m Tc-NTP 15-5 radiotracer for imaging primary growth of chondrosarcoma and its local recurrence after surgery.

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“…MR imaging is the best radiologic imaging method for evaluating the hyaline cartilage cap. The mineralized areas in the cartilage cap had a low signal intensity on the T1 and T2-weighted images [8,9].…”

Section: Resultsmentioning

confidence: 99%

Osteochondroma of the OsCalcaneum- A Case Report

Me²,

Mc³

et al. 2013

JCDR

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Magnetic resonance imaging of cartilaginous tumors: is it useful or necessary?

Abstract: MR imaging improves accuracy in diagnosing low-grade chondrosarcomas. Since osteochondromas have a characteristic appearance on plain films, MR imaging contributes only in the diagnostic workup of cases in which malignant transformation is suspected.

Cited by 86 publications

References 9 publications

Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

First Preclinical Imaging of Primary Cartilage Neoplasm and Its Local Recurrence Using ^99mTc-NTP 15-5 Radiotracer

Osteochondroma of the OsCalcaneum- A Case Report

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Magnetic resonance imaging of cartilaginous tumors: is it useful or necessary?

Abstract: MR imaging improves accuracy in diagnosing low-grade chondrosarcomas. Since osteochondromas have a characteristic appearance on plain films, MR imaging contributes only in the diagnostic workup of cases in which malignant transformation is suspected.

Cited by 86 publications

References 9 publications

Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

First Preclinical Imaging of Primary Cartilage Neoplasm and Its Local Recurrence Using 99mTc-NTP 15-5 Radiotracer

Osteochondroma of the OsCalcaneum- A Case Report

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Product

Resources

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First Preclinical Imaging of Primary Cartilage Neoplasm and Its Local Recurrence Using ^99mTc-NTP 15-5 Radiotracer