Magnetic Resonance Imaging of Cerebrospinal Fluid Volume and the Influence of Body Habitus and Abdominal Pressure

Hogan, Quinn H.; Prost, Robert; Kulier, Alexander; Taylor, Mary Lou; Liu, Spencer; Mark, Leighton P.

doi:10.1097/00132586-199704000-00051

Cited by 59 publications

(99 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3). In weighty patients, epidural fat storage may contribute to a reduced CSF flow rate [9]. Furthermore, weighty patients were reported to have increased central and retroperitoneal venous pressure [27], accompanied by a reduced pressure gradient between CSF and venous compartment.…”

Section: Discussionmentioning

confidence: 99%

Isolated blood–cerebrospinal fluid barrier dysfunction: prevalence and associated diseases

et al. 2005

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Isolated blood–cerebrospinal fluid barrier dysfunction: prevalence and associated diseases

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Conclusions in this study refer to the sample area in lumbosacral CSF space, because sample volume was small compared with total spinal CSF volume [9,15] and because lumbosacral CSF flow rate is low [6,21]. The results nevertheless show that some tested variables influence local CSF albumin concentration significantly.…”

Section: Discussionmentioning

confidence: 78%

“…This finding was unexpected and there is no obvious explanation. Lumbosacral CSF volume has been reported to correlate inversely with body mass index, partly due to epidural fat storage [15]. A decrease of CSF volume may be expected to increase CSF turnover [20], which could lower protein concentration.…”

Section: Discussionmentioning

confidence: 99%

“…A decrease of CSF volume may be expected to increase CSF turnover [20], which could lower protein concentration. However, weighty patients also have increased central and retroperitoneal venous pressure [15,27]. Pressure gradient between CSF and venous compartment, the driving force behind CSF bulk resorption [2,3], may then be reduced, which may lower CSF resorption, lessen CSF turnover and thus increase CSF protein concentration.…”

Section: Discussionmentioning

confidence: 99%

“…The length of spinal CSF path may influence CSF flow. b) Body weight has been reported to correlate inversely with spinal canal width [15]. Spinal canal width should influence CSF flow.…”

Section: S Group I Patientsmentioning

confidence: 98%

See 2 more Smart Citations

Determinants of lumbar CSF protein concentration

Seyfert¹,

Kunzmann²,

Schwertfeger³

et al. 2002

Journal of Neurology

View full text Add to dashboard Cite

Correlation of albumin quotient with body mass index and related variables may be mediated by spinal CSF resorption, which should be impaired in overweight patients with elevated venous pressure. Negative correlation of albumin quotient with iodine resorption from spinal CSF supports this assumption. Correlation of albumin quotient with narrowing of lumbosacral canal should be due to slowed spinal CSF flow which does increase protein concentration. Tested variables explain part of variation of CSF protein concentration. Other variables like blood-CSF barrier permeability and pulsatile spinal CSF flow should have additional influence.

show abstract

Spinal cerebrospinal fluid volume in healthy elderly individuals

et al. 2011

View full text Add to dashboard Cite

The amount of spinal cerebrospinal fluid (CSF) could be of importance for the understanding of CSF dynamics, CSF biomarker analyses as well as for the amount and effect of anaesthesia using intrathecally administered drugs. However, knowledge of spinal CSF volumes is scarce. The main purpose of this article is to present data on spinal CSF volumes. In total, 22 healthy individuals aged between 64 and 76 years underwent MR imaging with a 3D balanced turbo field echo pulse sequence, which provided high contrast between spinal cord, CSF and the extradural surroundings. The entire spinal CSF volume, the cervical, thoracic, and lumbosacral CSF volumes and the spinal cord volume were calculated. The total spinal CSF volume was 81 ± 13 ml (range 52-103 ml). The amount of CSF in the cervical region was 19 ± 4 ml, in the thoracic region 38 ± 8 and in the lumbosacral region 25 ± 7 ml. There was no difference between genders nor was there any correlation with height. The volume of the spinal cord was 20 ± 3 ml. The results present new magnetic resonance imaging-based data on the spinal CSF volume in healthy elderly individuals.

show abstract

Magnetic Resonance Imaging of Cerebrospinal Fluid Volume and the Influence of Body Habitus and Abdominal Pressure

Cited by 59 publications

References 0 publications

Isolated blood–cerebrospinal fluid barrier dysfunction: prevalence and associated diseases

Isolated blood–cerebrospinal fluid barrier dysfunction: prevalence and associated diseases

Determinants of lumbar CSF protein concentration

Spinal cerebrospinal fluid volume in healthy elderly individuals

Contact Info

Product

Resources

About