Magnetic resonance imaging of coronary atherosclerosis

Fayad, Zahi A.; Choudhury, Robin P.; Fuster, Valentín

doi:10.1007/s11883-003-0013-2

Cited by 6 publications

(5 citation statements)

References 62 publications

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“…Adventitia and thin layer of innermost media were poorly visible in coronary specimens. These observations corroborate with earlier report on thin fibrous cap, respiratory motion, and poor lipid rich moiety as factors for T2-weighted MRI visibility or Contrast Noise Ratio (CNR) of lumen narrowing [13,14]. In present study, short T2 plaque components were MR visible such as calcification and thrombus.…”

Section: Ex Vivo 900 Mhz Mr Micro Imaging Of Human Coronary Arteries and Aorta Histopathology Correlationsupporting

confidence: 93%

“…We believe that the size of atheroma and % stenosis serve as morphometric indices measured as wall thickness and lumen area. Further, plaque features such as disruption, fibrous cap, calcium and lipid deposits earlier highlighted the physiochemical processes in coronary wall [1][2][3][4]13,14]. In same direction, the present study demonstrated the enhanced power of MRI as tool of MRI-visible coronary vessel morphomteric measurements and plaque constituents to evaluate degree of stenosis and thrombosis.…”

Section: Discussionsupporting

confidence: 62%

“…This sequence enhanced the signal from flowing blood and a mixture of T2* and proton density contrast weighting highlighting the fibrous cap. Atherosclerotic plaque composition by MRI is generally based on the signal intensities and morphological appearance of the plaque on T1 weighted, proton density-weighted, and T2-weighted images as previously validated [13,14]. Optimized scan parameters and combined weighting generate good contrast for coronary artery features.…”

Section: Multicontrast Mr Plaque Imagingmentioning

confidence: 99%

“…In present study, the images were acquired with a resolution of 0.25 x 0.25 x 2.0 to 0.4 x 0.4 x 3.0 mm 3 by use of a coronary phased-array coil to improve signal-to-noise ratio and image resolution. A recent report reviewed the data on coronary aorta composition and atheroma size with the use of T1-weighted, T2-weighted, and proton density-weighted images at a resolution of 0.8 x 0.8 x 5.0 mm 3 using a phased array coil-high-resolution imaging or contrast-enhanced MRA by gadolinium-based contrast agents for plaque neovascularization, necrotic core and fibrous tissue [14].…”

Section: Ex Vivo 900 Mhz Mr Micro Imaging Of Human Coronary Arteries and Aorta Histopathology Correlationmentioning

confidence: 99%

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Human Coronary Artery Lesions: 900 MHz Magnetic Resonance Micro Imaging, NMR Spectroscopy, Histopathology and Oxidative Stress Markers

Rakesh¹

2017

JOCCT

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However, MRI measures lumen volume, wall thickness, thrombus size, total plaque volume and characterize the composition of the plaques. Noninvasive MRI is emerging tool for identification of flow-limiting coronary Stenoses, calcified plaques, imaging of the atherothrombotic lesions, measurement of atherosclerotic burden, and ex vivo characterization of the Abstract Aim: 900 MHz Magnetic resonance imaging (MRI) techniques measured the dimensions of atheroma and stenosis in excised human coronary plaque disruption and lipid disorder due to oxidative stress.Hypothesis: Coronary atheroma is a lipid disorder and MRI visible. Materials and Methods:Contiguous cross-sectional T2-weighted fast spin echo MRI images were point-by-point compared with coronary histopathology for quantitation of coronary wall and plaque features. Coronary atheroma tissues were used for NMR spectroscopy and oxidative stress content analysis.Results: 900 MHz MRI images showed distinct measurable wall thickness and vessel radii. The quantitative comparison of lumen areas and wall thickness in endarterectomy specimens using MRI images and histology images showed mean difference 5.0 % for lumen area and 4.5 % for wall thickness. MRI data correlated with the histopathology for aortic wall thickness (R 2 =0.92, P < 0.0001), plaque size (R 2 =0.99, P < 0.0001) and vessel radii (R2=0.79, P < 0.0001). MRI images and histological sections showed intraluminal thrombus and plaque disruption. High-resolution NMR peaks suggested the lipid-rich nature of coronary plaque due to presence of triglycerides, phospholipids, sterols and fatty acids. Oxidative stress markers were higher in plaque bearing coronary artery homogenates than the normal coronary artery homogenates. Ex vivo, 900 MHz MRI reliably determined the presence, location, and size of the thrombus and % stenosis in coronary artery atherosclerosis and histopathology defined the plaque composition. Conclusion:The study demonstrates the utility of MRI for in vivo measurement of % stenosis and distinguishes different components of coronary thrombus ex vivo suggesting the coronary artery plaque as a result of lipid disorder and oxidative stress.

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Section: Ex Vivo 900 Mhz Mr Micro Imaging Of Human Coronary Arteries and Aorta Histopathology Correlationsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 62%

Section: Multicontrast Mr Plaque Imagingmentioning

confidence: 99%

Section: Ex Vivo 900 Mhz Mr Micro Imaging Of Human Coronary Arteries and Aorta Histopathology Correlationmentioning

confidence: 99%

See 2 more Smart Citations

Human Coronary Artery Lesions: 900 MHz Magnetic Resonance Micro Imaging, NMR Spectroscopy, Histopathology and Oxidative Stress Markers

Rakesh¹

2017

JOCCT

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“…MRI is a very attractive method for in vivo analysis of the basic biology of atherosclerosis, from preclinical evaluation to clinical detection, diagnosis, and prognosis [3][4][5][6][7][8][9][10][11]. The advantages of MRI include excellent spatial resolution, which may be as high as 200-300 µm in vivo using specific sequences with clinical magnets (1.5 Tesla), although this is still insufficient to directly visualize the microvasculature, constituted by vessels with a caliber of 100 µm or less.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Atherosclerosis Neovascularization and Imaging

Purushothaman¹,

Sanz²,

Zias³

et al. 2006

CMM

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Neovascularization in atherosclerotic plaques is particularly prominent in complicated lesions, and has been recently identified as a marker of plaque vulnerability. This observation has led to a growing interest in the development of imaging techniques with the ability to visualize and quantify the extent of plaque neovascularization. Such feature may play an important role in identifying those lesions more prone to destabilization and rupture, and in the guidance and monitoring of therapeutic interventions. Several modalities have emerged as potential candidates for imaging neovessels in atherosclerotic lesions. They include magnetic resonance imaging, x-ray computed tomography, positron emission tomography, single photon emission computed tomography, ultrasound, or near-infrared optical imaging. These techniques differ in their achievable spatial and temporal resolution, availability, cost, reproducibility, degree of intrusiveness, capability to image atherosclerotic plaques in various vascular territories and ability to discern different plaque components, specifically the presence of neovessels. Molecular imaging, a rapidly evolving multidisciplinary field devoted to the visualization of specific physiopathologic processes at the cellular or molecular level, appears particularly well suited for this purpose because of its ability to target and visualize individual molecules specific to neoangiogenesis. In this manuscript we will review current evidence on the potential application of the various modalities, with a particular emphasis in molecular imaging.

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