Magnetic resonance imaging of diffusion and perfusion

Me, Moseley; Mf, Wendland; Kucharczyk, John

doi:10.1097/00002142-199106000-00008

Cited by 48 publications

(33 citation statements)

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“…It is well known from diffusion imaging of stroke that cells in the early stages of irreversible ischemia demonstrate restricted diffusion. [36][37][38][39][40] Ischemic cells in a brain tumor also likely demonstrate decreased signal intensity on the ADC maps.…”

Section: Possible Explanationsmentioning

confidence: 99%

Apparent Diffusion Coefficient of Glial Neoplasms: Correlation with Fluorodeoxyglucose–Positron-Emission Tomography and Gadolinium-Enhanced MR Imaging

Holodny¹,

Makeyev²,

Beattie³

et al. 2010

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Gd-enhancement provides essential information in the assessment of brain tumors. However, enhancement does not always correlate with histology or disease activity, especially in the setting of current therapies. Our aim was to compare FDG-PET scans to ADC maps and Gd-enhanced MR images in patients with glial neoplasms to assess whether DWI might offer information not available on routine MR imaging sequences and whether such findings have prognostic significance.

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Section: Possible Explanationsmentioning

confidence: 99%

Apparent Diffusion Coefficient of Glial Neoplasms: Correlation with Fluorodeoxyglucose–Positron-Emission Tomography and Gadolinium-Enhanced MR Imaging

Holodny¹,

Makeyev²,

Beattie³

et al. 2010

AJNR Am J Neuroradiol

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“…[1][2][3] While imaging changes in diffusion have found their greatest clinical utility in the assessment of the human brain, the spine and spinal cord could also benefit from diffusion imaging. Because of the small size of the spinal cord and other technical challenges related to spine imaging, DWI is less often performed for these examinations.…”

mentioning

confidence: 99%

Clinical Evaluation of Reduced Field-of-View Diffusion-Weighted Imaging of the Cervical and Thoracic Spine and Spinal Cord

Andre¹,

Zaharchuk²,

Sarıtaş

et al. 2012

AJNR Am J Neuroradiol

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“…The advent of new MRI techniques such as perfusion-and diffusion-weighted imaging (PWI and DWI, respectively) has revolutionized diagnostic imaging in stroke. [5][6][7][8][9][10][11][12] It is presumed that the difference (mismatch) between abnormal areas on DWI and PWI (with PWIϾDWI) represents the ischemic tissue at risk, which is potentially salvageable. 8,11,13 Several investigators have found a significant correlation of DWI and PWI changes with follow-up T2-weighted imaging (T2WI) changes as well as with neurological outcome as assessed by the National Institutes of Health Stroke Scale (NIHSS) and the Barthel Index (BI).…”

mentioning

confidence: 99%

Monitoring Intravenous Recombinant Tissue Plasminogen Activator Thrombolysis for Acute Ischemic Stroke With Diffusion and Perfusion MRI

Schellinger

Jansen

Fiebach

et al. 2000

Stroke

161

116

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Background and Purpose-Intravenous recombinant tissue plasminogen activator (rtPA) administration is an effective therapy for ischemic stroke when initiated within 3 hours and possibly up to 6 hours after symptom onset. To improve patient selection, a fast diagnostic tool that allows reliable diagnosis of hemorrhage and ischemia, vessel status, and tissue at risk at an early stage may be useful. We studied the feasibility of stroke MRI for the initial evaluation and follow-up monitoring of patients undergoing intravenous thrombolysis. Methods-Stroke MRI (diffusion-and perfusion-weighted imaging [DWI and PWI, respectively], magnetic resonance angiography, and T2-weighted imaging) was performed before, during, or after thrombolysis and on days 2 and 5. We assessed clinical scores (National Institutes of Health Stroke Scale [NIHSS], Scandinavian Stroke Scale [SSS], Barthel Index, and Rankin scale) at days 1, 2, 5, 30, and 90. Furthermore, we performed volumetric analysis of infarct volumes on days 1, 2, and 5 as shown in PWI, DWI, and T2-weighted imaging. Results-Twenty-four patients received rtPA within a mean time interval after symptom onset of 3.27 hours and stroke MRI of 3.43 hours. Vessel occlusion was present in 20 of 24 patients; 11 vessels recanalized (group 1), and 9 did not (group 2). The baseline PWI lesion volume was significantly larger (Pϭ0.008) than outcome lesion size in group 1, whereas baseline DWI lesion volume was significantly smaller (Pϭ0.008) than final infarct size in group 2. Intergroup outcome differed significantly for all scores at days 30 and 90 (all PϽ0.01). Intragroup differences were significant in group 1 for change in SSS and NIHSS between day 1 and day 30 (Pϭ0.003) and for SSS only between day 1 and day 90 (Pϭ0.004). Conclusions-Stroke MRI provides comprehensive prognostically relevant information regarding the brain in hyperacute stroke. Stroke MRI may be used as a single imaging tool in acute stroke to identify and monitor candidates for thrombolysis. It is proposed that stroke MRI is safe, reliable, and cost effective; however, our data do not prove this assumption. Early recanalization achieved by thrombolysis can save tissue at risk if present and may result in significantly smaller infarcts and a significantly better outcome.

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Magnetic resonance imaging of diffusion and perfusion

Cited by 48 publications

References 0 publications

Apparent Diffusion Coefficient of Glial Neoplasms: Correlation with Fluorodeoxyglucose–Positron-Emission Tomography and Gadolinium-Enhanced MR Imaging

Apparent Diffusion Coefficient of Glial Neoplasms: Correlation with Fluorodeoxyglucose–Positron-Emission Tomography and Gadolinium-Enhanced MR Imaging

Clinical Evaluation of Reduced Field-of-View Diffusion-Weighted Imaging of the Cervical and Thoracic Spine and Spinal Cord

Monitoring Intravenous Recombinant Tissue Plasminogen Activator Thrombolysis for Acute Ischemic Stroke With Diffusion and Perfusion MRI

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