Magnetic resonance imaging of focal and diffuse hepatic disease

Siegelman, Evan S.; Outwater, Eric K.

doi:10.1016/s0887-2171(98)90022-1

Cited by 7 publications

(23 citation statements)

References 272 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the basis of data obtained by using liver-specific agents in nuclear medicine and magnetic resonance (MR) imaging, we hypothesized that specificity could also be improved. High uptake of sulphur colloid or superparamagnetic iron oxide agents is known to be a feature of focal nodular hyperplasia (FNH) (12,13) and can reveal their characteristic central scars (14). This uptake is attributable to the presence of Kupffer cells within these lesions.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Do Different Types of Liver Lesions Differ in Their Uptake of the Microbubble Contrast Agent SH U 508A in the Late Liver Phase? Early Experience

Blomley

Sidhu²,

Cosgrove³

et al. 2001

Radiology

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

“…In general, benign lesions show enhancement, while malignancies do not (13,14). Vogl et al (16) studied the superparamagnetic iron oxide agent AMI-25 and found that normal liver, FNH, and adenomas all showed enhancement, while metastases and HCC did not.…”

Section: Discussionmentioning

confidence: 99%

Do Different Types of Liver Lesions Differ in Their Uptake of the Microbubble Contrast Agent SH U 508A in the Late Liver Phase? Early Experience

Blomley

Sidhu²,

Cosgrove³

et al. 2001

Radiology

View full text Add to dashboard Cite

show abstract

“…Tissue contrast can be enhanced by utilizing the slight difference in the natural frequencies of hydrogen protons in fat versus water to suppress selectively the signal from hydrogen protons in fat (fat saturation), or to achieve phase cancellation in tissues containing both fat and water, such as in focal fatty infiltration of the liver. 4 …”

Section: Tissue Contrastmentioning

confidence: 99%

“… 33 Haemangiomas have a characteristic appearance after gadolinium injection of early peripheral enhancement followed by gradual centripetal filling of the remainder of the lesion over 5–10 min. 2,4,34 This early peripheral enhancement has a discontinuous nodular appearance. Unfortunately, up to 60% of haemangiomas, particularly small haemangiomas, do not show all the typical imaging features; they may have a heterogeneous appearance, an irregular outline and immediate uniform enhancement.…”

Section: Non‐malignant Space‐occupying Lesionsmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic resonance imaging (MRI) and diseases of the liver and biliary tract. Part 1. Basic principles, MRI in the assessment of diffuse and focal hepatic disease

Macdonald

Peduto

2000

J of Gastro and Hepatol

View full text Add to dashboard Cite

15, [980][981][982][983][984][985][986][987][988][989][990][991] imaging procedure, with significantly fewer reactions to contrast agents than computed tomography (CT) imaging, has no ionizing radiation and only a limited number of contraindications. For these reasons, and because of the recent advances in MRI technique discussed in the following text, there are specific indications for MRI in hepatobiliary imaging. Because there is limited access to MRI technology, these indications need to be understood so that optimal use can be made of the available resources.This review will discuss findings from studies focusing on the more common clinical problems. Developments in the field of hepatobiliary imaging using MRI are occurring rapidly, particularly in the area of MRCP, and techniques reported in the most recent literature INTRODUCTIONThere are a number of particular advantages of magnetic resonance imaging (MRI) that make it useful for the diagnosis of clinical problems. These advantages include tissue contrast inherent in the technique, and the fact that this can be enhanced by a number of positive and negative contrast agents. Dynamic contrast scanning further improves the diagnostic utility of MRI. Fat has specific MRI characteristics that allow it to be assessed during conventional MRI, while the MRI characteristics of stationary and mobile liquids makes MR cholangiopancreatography (MRCP) and MR angiography (MRA) powerful non-invasive diagnostic tools. Abstract Magnetic resonance imaging (MRI) relies on the physical properties of unpaired protons in tissues to generate images. Unpaired protons behave like tiny bar magnets and will align themselves in a magnetic field. Radiofrequency pulses will excite these aligned protons to higher energy states. As they return to their original state, they will release this energy as radio waves. The frequency of the radio waves depends on the local magnetic field and by varying this over a subject, it is possible to build the images we are familiar with. In general, MRI has not been sufficiently sensitive or specific in the assessment of diffuse liver disease for clinical use. However, because of the specific characteristics of fat and iron, it may be useful in the assessment of hepatic steatosis and iron overload. Magnetic resonance imaging is useful in the assessment of focal liver disease, particularly in conjunction with contrast agents.Haemangiomas have a characteristic bright appearance on T 2 weighted images because of the slow flowing blood in dilated sinusoids. Focal nodular hyperplasia (FNH) has a homogenous appearance, and enhances early in the arterial phase after gadolinium injection, while the central scar typically enhances late. Hepatic adenomas have a more heterogenous appearance and also enhance in the arterial phase, but less briskly than FNH. Hepatocellular carcinoma is similar to an adenoma, but typically occurs in a cirrhotic liver and has earlier washout of contrast. The appearance of metastases depends on the underlying primary malignancy. Overal...

show abstract

Magnetic resonance imaging of the prostate

Siegelman

1999

Seminars in Roentgenology

View full text Add to dashboard Cite

Magnetic resonance imaging of focal and diffuse hepatic disease

Cited by 7 publications

References 272 publications

Do Different Types of Liver Lesions Differ in Their Uptake of the Microbubble Contrast Agent SH U 508A in the Late Liver Phase? Early Experience

Do Different Types of Liver Lesions Differ in Their Uptake of the Microbubble Contrast Agent SH U 508A in the Late Liver Phase? Early Experience

Magnetic resonance imaging (MRI) and diseases of the liver and biliary tract. Part 1. Basic principles, MRI in the assessment of diffuse and focal hepatic disease

Magnetic resonance imaging of the prostate

Contact Info

Product

Resources

About