Magnetic resonance imaging of inflammatory reaction in osteoid osteoma

Yamamura, S.; Sato, Keiji; Sugiura, Hideshi; Asano, Masayoshi; Takahashi, Mitsuru; Iwata, Hiroji

doi:10.1007/bf00454728

Cited by 25 publications

(13 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These appearances can be confusing, although the mere presence and quantity of marrow and soft tissue edema are unreliable indicators of the biological potential of a lesion [16]. Features indicative of tumor-associated bone marrow edema are frequently found in benign disorders such as osteoid osteoma, osteoblastoma and chondroblastoma [16,17,18,19,20]. Weatherall et al [7] found 19 of 22 patients with chondroblastoma had bone marrow edema and a periosteal reaction was demonstrated in 18 patients, while Jee et al [6] reported 82% with similar features.…”

Section: Discussionmentioning

confidence: 99%

Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation

Kaim¹,

Hügli²,

Bonél³

et al. 2001

Skeletal Radiol

117

View full text Add to dashboard Cite

Objective: To analyze and compare the radiological and magnetic resonance imaging (MRI) appearances of chondroblastoma and clear cell chondrosarcoma with histopathological correlation. Design and patients: Twelve patients with histologically proven chondroblastoma and of another four patients with clear cell chondrosarcoma were investigated by radiographs and MRI (T1-, T2-weighted sequences, intravenous gadolinium application). Additionally, the clinical and radiologic data of seven cases of clear cell chondrosarcoma without available MRI were considered. The localization, calcification of tumor matrix, periosteal reaction, cortical bone and patterns of bone destruction were analyzed according to the Lodwick radiological grading system (LRGS). The signal intensity on T1-and T2-weighted sequences, characteristics of contrast enhancement, associated bone marrow edema, soft tissue reaction and joint involvement were evaluated. Histopathological specimens were available in all cases. Results: The age of patients with chondroblastoma (range 15-59 years, mean 22.3 years) was lower than that of those with clear cell chondrosarcoma (range 19-61 years, mean 36.6 years), and the lesions were smaller in the chondroblastoma group (range 1-4 cm, mean 2.3 cm) than in patients with clear cell chondrosarcoma (range 3-7.5 cm, mean 5.2 cm). The chondroblastomas were more confined to the epiphysis (10/12) than the clear cell chondrosarcomas. All chondroblastomas and clear cell chondrosarcomas except one were classified as grade 1A or 1B according to the LRGS; one clear cell chondrosarcoma was judged as grade 2. Signal intensity of the tumors on MRI was very heterogeneous in both groups. High signal intensity on T2-weighted MR images in chondroblastoma mostly corresponded to areas with aneurysmal bone cyst components and in clear cell chondrosarcoma to islands of hyaline cartilage. Contrast enhancement occurred in all tumors and tended to be more intense with clear cell chondrosarcoma. Chondroblastoma was more frequently associated with bone marrow edema (11/12), periosteal reaction (10/12), soft tissue reaction (7/12) and synovitis (3/12). Conclusion: Chondroblastoma occurs in younger patients, is smaller than clear cell chondrosarcoma and is more confined to the epiphysis. The overlap of signal intensity and contrast enhancement patterns does not allow a reliable differentiation of the two tumors by MRI. Chondroblastomas are typically associated with bone marrow edema, periosteal reaction and soft tissue reaction.

show abstract

Section: Discussionmentioning

confidence: 99%

Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation

Kaim¹,

Hügli²,

Bonél³

et al. 2001

Skeletal Radiol

117

View full text Add to dashboard Cite

show abstract

“…Prostaglandins produced by the tumour result in a chronic inflammatory response in the surrounding tissues which is demonstrated by a periosteal reaction and synovitis. These regress spontaneously after removal of the nidus [9,17].…”

Section: Introductionmentioning

confidence: 99%

Osteoid osteoma: the results of surgical treatment

Yıldız

Bayrakçı

Altay

et al. 2001

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

Between 1987 and 1999 we diagnosed and treated 110 patients with osteoid osteoma. Sixty patients were younger than 20 years. One hundred and four patients had characteristic pain at night. The mean duration of symptoms before surgery was 16 months. One hundred and four symptomatic patients were treated operatively with either wide resection or curettage. Ninety-one patients had immediate and complete relief of pain. The average follow-up was 2.5 years.Résumé Entre 1987 et 1999 nous avons traités 110 malades souffrant d'un ostéome osteoide. 60 malades étaient âgés de moins de 20 ans. 104 malades avaient la douleur nocturne caractéristique. La durée moyenne de symptô-mes avant la chirurgie était de 16 mois. 104 malades symptomatiques ont été opérés avec résection large ou curetage. 91 malades ont eu un soulagement immédiat et complet des douleurs. La moyenne de suivi était de 2.5 années.

show abstract

“…Recent use of MRI has not only allowed depiction of the nidus, but also provided information on accompanying phenomenon such as intramedullary intensity changes, peritumoral soft‐tissue intensity changes and retention of joint fluid in intra‐articular cases. However, the mechanisms of these phenomena remain unknown 3,4,12,13 …”

Section: Discussionmentioning

confidence: 99%

Mechanism of intramedullary high intensity area on T2‐weighted magnetic resonance imaging in osteoid osteoma: A possible role of COX‐2 expression

Kawaguchi¹,

Hasegawa²,

Oka³

et al. 2001

Pathology International

View full text Add to dashboard Cite

To study the mechanism and pathophysiology of the development of intramedullary high intensity areas on T2-weighted magnetic resonance images (MRI) in cases of osteoid osteoma, we examined the expression of cyclooxygenase-2 (COX-2) in the nidus and surrounding bone tissues. In all six cases showing a marked intramedullary high intensity area adjacent to the nidus before surgery, neoplastic osteoblasts inside the nidus showed strong and diffuse COX-2 immunoreactivity. On the other hand, the osteoblasts rimming the surrounding reactive bone were COX-2 negative. In two cases examined by reverse transcription-polymerase chain reaction (RT-PCR), COX-2 mRNA was detected in abundance in the nidus. Histologically, vascular dilatation together with intramedullary edema was observed in all cases, which was probably reflected as a high intensity area on T2-weighted MRI. From our study, a high level of COX-2 expression in neoplastic osteoblasts in the nidus of osteoid osteomas may cause the secondary changes depicted by MRI.

show abstract

Magnetic resonance imaging of inflammatory reaction in osteoid osteoma

Cited by 25 publications

References 11 publications

Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation

Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation

Osteoid osteoma: the results of surgical treatment

Mechanism of intramedullary high intensity area on T2‐weighted magnetic resonance imaging in osteoid osteoma: A possible role of COX‐2 expression

Contact Info

Product

Resources

About