Magnetic resonance imaging of limbic encephalitis

Kodama, Takahide; Numaguchi, Yuji; Gellad, Fouad; Dwyer, B. A.; Kristt, Donald A.

doi:10.1007/bf00588045

Cited by 32 publications

(5 citation statements)

References 14 publications

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“…Findings are hyperintense signals on fluid-attenuated inversion recovery and T2-weighted images in the medial temporal lobe(s), frequently without enhancement after contrast administration. [6][7][8][9] However, a normal MRI finding does not exclude PLE. 1,5 The existing literature of positron emission tomography (PET) in PLE is scarce.…”

mentioning

confidence: 99%

Serial 18F-fluoro-2-deoxy-D-glucose Positron Emission Tomography and Magnetic Resonance Imaging of Paraneoplastic Limbic Encephalitis

Scheid¹,

Lincke²,

Voltz³

et al. 2004

Arch Neurol

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The results of functional and structural imaging in PLE may differ substantially. Results of FDG-PET can demonstrate focal hypermetabolism over a long time, which may indicate therapeutic potential. A prospective study with more patients will be needed to clarify the relevance of PET as a possible outcome measure in PLE. Future studies should include scalp or semi-invasive electroencephalographic recordings during PET acquisition.

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mentioning

confidence: 99%

Serial 18F-fluoro-2-deoxy-D-glucose Positron Emission Tomography and Magnetic Resonance Imaging of Paraneoplastic Limbic Encephalitis

Scheid¹,

Lincke²,

Voltz³

et al. 2004

Arch Neurol

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“…Neuropathological studies have showed chronic perivascular inflammatory changes in the meninges, encephalitis with lymphocytic infiltrates of the medial temporal lobes (7,21).The histological and clinical findings were possibly due to an autoimmune phenomenon. The pathogenesis of LE-complicating malignancy is not clear.…”

Section: Discussionmentioning

confidence: 96%

“…Imaging studies has an important role in the diagnosis of LE, especially in eliminating the need for brain biopsy (11,21,22,23). CT findings are often normal, but have occasionally shown a hypodense lesion in the medial aspect of one or both temporal lobes (24).…”

Section: Discussionmentioning

confidence: 98%

Sistemik Lupus Eritematozusun Eşlik Ettiği Limbik Ensefalit: Olgu Sunumu

Selçuk¹,

Kızılkılıç²,

Albayram³

et al. 2011

Npa

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“…The median age at thymoma diagnosis was 44.5 years, from age 19 to 69. The earliest case was reported by Kodama et al 7 in 1991, in which a 34-year-old woman was found to have a thymoma after presenting with AE and MG symptoms at the same time. Due to the limitation of detection technique, AE-associated antibody was not detected in this patient.…”

Section: Literature Reviewmentioning

confidence: 99%

Thymoma‐associated autoimmune encephalitis with myasthenia gravis: Case series and literature review

Su,

Luo,

et al. 2024

CNS Neurosci Ther

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ObjectivesThis comprehensive review aimed to compile cases of patients with thymoma diagnosed with both autoimmune encephalitis (AE) and myasthenia gravis (MG), and describe their clinical characteristics.MethodsClinical records of 3 AE patients in the first affiliated hospital of Sun Yat‐sen University were reviewed. All of them were diagnosed with AE between 1 November 2021 and 1 March 2022, and clinical evidence about thymoma and MG was found. All published case reports were searched for comprehensive literature from January 1990 to June 2022.ResultsA total of 18 cases diagnosed with thymoma‐associated autoimmune encephalitis (TAAE) and thymoma‐associated myasthenia gravis (TAMG) were included in this complication, wherein 3 cases were in the first affiliated hospital of Sun Yat‐sen University and the other 15 were published case reports. 5/18 patients had alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor antibody (AMPAR‐Ab) in their serum and cerebrospinal fluid (CSF). All of them had positive anti‐acetylcholine receptor antibody (AChR‐Ab). And 12/18 patients showed a positive response to thymectomy and immunotherapy. Besides, thymoma recurrences were detected because of AE onset. And the shortest interval between operation and AE onset was 2 years in patients with thymoma recurrence.ConclusionsThere was no significant difference in the clinical manifestations between these patients and others with only TAMG or TAAE. TAAE was commonly associated with AMPAR2‐Ab. Significantly, AE more commonly heralded thymoma recurrences than MG onset. And the intervals of thymectomy and MG or AE onset had different meanings for thymoma recurrence and prognoses of patients.

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Magnetic resonance imaging of limbic encephalitis

Abstract: In two patients with limbic encephalitis serial magnetic resonance (MR) imaging showed evolution of abnormal high-signal intensity in both hippocampal formations on T2-weighted images.

Cited by 32 publications

References 14 publications

Serial 18F-fluoro-2-deoxy-D-glucose Positron Emission Tomography and Magnetic Resonance Imaging of Paraneoplastic Limbic Encephalitis

Serial 18F-fluoro-2-deoxy-D-glucose Positron Emission Tomography and Magnetic Resonance Imaging of Paraneoplastic Limbic Encephalitis

Sistemik Lupus Eritematozusun Eşlik Ettiği Limbik Ensefalit: Olgu Sunumu

Thymoma‐associated autoimmune encephalitis with myasthenia gravis: Case series and literature review

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