Magnetic resonance imaging of primary cerebral gliosarcoma: a report of 15 cases

Han, Lei; Zhang, X.; Qiu, Shuqing; Li, X.; Xiong, Wei; Zhang, Y.; Qu, Hongling; Chang, Ren-Min; Chen, B.; Wang, W.; Li, S.

doi:10.1080/02841850802314796

Cited by 34 publications

(37 citation statements)

References 30 publications

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“…19,27,29 Therefore, the presence of hemorrhage was not helpful in the differential diagnosis of these tumors. Some similarities in the imaging appearances of AT/RT and glioblastoma or gliosarcoma have been reported, 38 because those kinds of tumors have a predilection for similar sites and modes of enhancement, with calcification and destruction of the skull as key distinguishing features. Calcification had been documented in high-grade oligodendroglioma and in some cases of AT/RT in adult patients, so the presence of calcification was not helpful in the differential diagnosis of these tumors.…”

Section: Discussionmentioning

confidence: 99%

Atypical Teratoid/Rhabdoid Tumors in Adult Patients: CT and MR Imaging Features

Han¹,

Qiu²,

Xie³

et al. 2010

AJNR Am J Neuroradiol

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SUMMARY:Primary AT/RT is a rare highly malignant tumor of the CNS, usually occurring in children younger than 5 years of age. The objective of this study was to characterize the CT and MR imaging findings in a series of 5 adult patients with pathologically proved AT/RT. All 5 AT/RTs were supratentorial. In 2 patients who underwent nonenhanced CT, the tumors appeared isoattenuated, and 1 of the 2 tumors contained calcifications. Solid portions of the tumors on MR imaging were isointense on T1-weighted, T2-weighted, and FLAIR images, and 1 case showed restricted diffusion on DWI. The tumors also demonstrated a bandlike rim of strong enhancement surrounding a central cystic area on contrast-enhanced T1-weighted imaging. One tumor was associated with destruction of the calvaria. Although AT/RTs can have nonspecific findings, the tumors in our series were large and isointense on T1-weighted, T2-weighted, and FLAIR images with central necrosis and prominent rim enhancement.ABBREVIATIONS: ADC ϭ apparent diffusion coefficient; AT/RT ϭ atypical teratoid/rhabdoid tumor; CNS ϭ central nervous system; DWI ϭ diffusion-weighted imaging; FLAIR ϭ fluid-attenuated inversion recovery; L ϭ left; mRNA ϭ messenger ribonucleic acid; N/A ϭ not available, ND ϭ not depicted; OS ϭ overall survival; PNET ϭ primitive neuroectodermal tumor; PR ϭ partial resection; R ϭ right; TR ϭ total resection A lthough AT/RT was first described as a rare, highly malignant childhood neoplasm of the kidney, it has also been reported at several extrarenal sites including the skin, chest wall, liver, thymus, optic nerve, and the CNS. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] When found in the CNS, it usually arises from the posterior fossa and is most commonly found in children younger than 5 years of age.17 To our knowledge, only 29 cases of primary AT/RT of the CNS in adults have been reported (On-line Table). 18-30The On-line Table summarizes the clinical and imaging data from our patients and from those in the literature.The prognosis of patients with an AT/RT is poor, especially in patients younger than 3 years of age, with a survival time that averages 15 months in children and 38 months in adults. 10,18,19,24 To our knowledge, there are only limited case reports describing the imaging features of this entity in adults. 8,9,18,19,[21][22][23][24][25][26][27][28][29][30][31] The goal of this study was to characterize the CT and MR imaging features of CNS AT/RT in 5 adults. Materials and Methods PatientsThis study was approved by our institutional review board in accordance with standards of the National Institutes of Health. Five consecutive adult patients who received a diagnosis of AT/RT from January 2001 to October 2009 were included in the study. All patients had undergone surgical resection of their tumor and had received postoperative radiation therapy and chemotherapy. The resection specimens were collected and analyzed at 1 central pathology laboratory. Definitive diagnosis was based on histologic and immunohistochemical evaluation...

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Section: Discussionmentioning

confidence: 99%

Atypical Teratoid/Rhabdoid Tumors in Adult Patients: CT and MR Imaging Features

Han¹,

Qiu²,

Xie³

et al. 2010

AJNR Am J Neuroradiol

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“…On imaging, they are seen as surfacing lesion, often having a thick dural attachment (5). We report a very unusual case of an intraventricular gliosarcoma (IVGS) in a 60-year-old female.…”

Section: Saf İntraventriküler Kökenli Gliosarkom -Nadir Bir Durummentioning

confidence: 99%

Pure intraventricular origin of gliosarcoma – a rare entity

Sarkar¹,

Sunil²,

Ghosh³

2012

Turkish Neurosurgery

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Gliosarcomas (GS) are high grade, rare tumours. Radiologically they are seen as a surfacing lesion, often having a thick dural attachment located within the parenchyma of the brain. We report a very unusual case of an intraventricular non-parenchyhmal gliosarcoma in a 60-yearold female. Magnetic resonance imaging of the brain revealed a well defined brilliantly enhancing mass located in the septal region and extending into the body and the frontal horn of the lateral ventricle on either side. The mass was isointense on T1-weighted sequences and hypointense on T2-weighted sequences. Very few reports that describe this entity exist and our case report adds to the sparse literature.KeywoRds: Gliosarcoma, Intraventricular, Non parenchymal ÖZ Gliosarkomlar (GS) yüksek dereceli, nadir tümörlerdir. Radyolojik olarak sıklıkla beyin parankiminde bulunan kalın dural bir tutulma kısmıyla yüzeye çıkan bir lezyon olarak görülürler. Burada 60 yaşında bir kadında intraventriküler nonparenkimal gliosarkom şeklinde çok nadir bir vakayı sunuyoruz. Beynin manyetik rezonans görüntülemesi septal bölgede çok parlak şekilde kontrast madde tutan iyi tanımlanmış bir kitleyi ve her iki tarafta lateral ventrikülün frontal kornusu ve gövdesine uzanmasını gösterdi. Kitle T1 ağırlıklı dizilerde izointens ve T2-ağırlıklı dizilerde hipointensti. Bu varlığı tanımlayan çok az sayıda rapor vardır ve vaka raporumuz bu az sayıda yayına katkıda bulunmaktadır.

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“…Radiologically, two patterns have been described: a peripherally located lesion involving the cortex associated with dural thickening and a central location with transependymal infiltration into the ventricles with 67% of primary and all secondary gliosarcomas being peripherally situated . Intraventricular location is uncommon to primary gliosarcoma and only a few cases have been documented . In a series of 15 cases of gliosarcoma, two were found to be intraventricular in location …”

Section: Discussionmentioning

confidence: 99%

“…Intraventricular location is uncommon to primary gliosarcoma and only a few cases have been documented . In a series of 15 cases of gliosarcoma, two were found to be intraventricular in location …”

Section: Discussionmentioning

confidence: 99%

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Intraventricular gliosarcoma with dual sarcomatous differentiation: A unique case

et al. 2017

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Gliosarcoma, a variant of isocitrate dehydrogenase-wildtype glioblastoma, is largely a lobar surfacing neoplasm often with dural attachment. In this biphasic neoplasm, the sarcomatous component usually takes the form of fibrosarcoma or malignant fibrous histiocytoma. Heterologous sarcomatous differentiation is a rare phenomenon. Here, we present a case of gliosarcoma with liposarcomatous and myosarcomatous differentiation in a 68-year-old man which was purely intraventricular. This is the first report of such a morphologic pattern in this location. Varied histological components with their immunohistochemical profile are discussed. Of note was the presence of a p53 negative giant cell glioblastoma component, as was the expression in the rest of the tumor.

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Magnetic resonance imaging of primary cerebral gliosarcoma: a report of 15 cases

Cited by 34 publications

References 30 publications

Atypical Teratoid/Rhabdoid Tumors in Adult Patients: CT and MR Imaging Features

Atypical Teratoid/Rhabdoid Tumors in Adult Patients: CT and MR Imaging Features

Pure intraventricular origin of gliosarcoma – a rare entity

Intraventricular gliosarcoma with dual sarcomatous differentiation: A unique case

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