2004
DOI: 10.1007/s10334-004-0082-4
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Magnetic resonance imaging of regional cardiac function in the mouse

Abstract: In this paper we introduce an improved harmonic phase (HARP) analysis for complementary spatial modulation of magnetization (CSPAMM) tagging of the mouse left ventricular wall, which enables the determination of regional displacement fields with the same resolution as the corresponding CINE anatomical images. CINE MRI was used to measure global function, such as the ejection fraction. The method was tested on two healthy mouse hearts and two mouse hearts with a myocardial infarction, which was induced by a lig… Show more

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Cited by 26 publications
(23 citation statements)
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“…Mice were anesthetized with 1.5-2.0% isoflurane and were placed in supine position in a home-built cradle with sensors to continuously monitor the electrocardiogram (ECG), respiration and temperature (Small Animal Instruments Inc., Stony Brook, USA) [23].…”
Section: In Vivo Mrimentioning
confidence: 99%
“…Mice were anesthetized with 1.5-2.0% isoflurane and were placed in supine position in a home-built cradle with sensors to continuously monitor the electrocardiogram (ECG), respiration and temperature (Small Animal Instruments Inc., Stony Brook, USA) [23].…”
Section: In Vivo Mrimentioning
confidence: 99%
“…The cine MR images were analyzed on a slice-by-slice basis using the semiautomatic validated segmentation software CAAS MRV FARM (Pie Medical Imaging) to obtain EDV, ESV, and EF (23,24). Free papillary muscles were not included into the myocardial compartment.…”
Section: Data Processingmentioning
confidence: 99%
“…Tagging techniques based on 2D SPAtial Modulation of Magnetization (SPAMM) in combination with ECG-gated cine images have also been implemented in small rodents for detailed analysis of the myocardial wall motion. [215][216][217][218] Displacement encoded imaging using stimulated echoes (DENSE) [219][220][221] has also provided detailed analysis of myocardial wall motion, in rodents 222 and in canines. 223 Furthermore MRI is capable of visualizing microstructures such as the coronary arteries and the heart valves of a living mouse.…”
Section: Cardiovascular Disordersmentioning
confidence: 99%