Magnetic resonance imaging of the breasts: Clinical practice and further development

Milošević, Zorica; Spasic, Nenad

doi:10.2298/sarh0408260m

Cited by 2 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Calcifications are not present in all DCIS lesions, lowering the sensitivity of mammography to 70-80% (5). Contrast-enhanced magnetic resonance imaging (CE-MRI) shows high sensitivity in DCIS detection (77-96%) (6-8). DCIS is considered as the direct precursor of invasive carcinoma usually in the same quadrant (9, 10).…”

Section: Introductionmentioning

confidence: 99%

“…Gadolinium (Gd-DTPA) is the extracellular contrast agent distributed in the vascular and then in the interstitial compartment (6). The contrast perfusion rate from blood vessels into the interstitial compartment increases with the grade of malignancy and the vascular density (1).…”

Section: Introductionmentioning

confidence: 99%

“…The contrast perfusion rate from blood vessels into the interstitial compartment increases with the grade of malignancy and the vascular density (1). The risk of malignancy depends on the kinetic pattern, ranging from 6% in type I and 64% in type II to 87% in type III (6, 7, 16-18). Rapid uptake is most often associated with DCIS in the initial phase, while all three types of curves are seen in the delayed phase, of which the plateau type is the most common (15, 16).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Breast Ductal Carcinoma in Situ (DCIS): Morphologic and Kinetic MRI Findings

2013

View full text Add to dashboard Cite

BackgroundAdequate diagnosis of ductal carcinoma in situ (DCIS) could lead to efficacious treatment. Due to the fact that DCIS lesions can progress to invasive carcinomas and that the sensitivity of the standard examination – mammography – is between 70 and 80%, use of a more sensitive diagnostic tool was needed. In detection of DCIS, contrast-enhanced magnetic resonance imaging (CE-MRI) has the sensitivity up to 96%.ObjectivesMorphological features and kinetic parameters were evaluated to define the most regular morphological, kinetic and morpho-kinetic patterns on MRI assessment of breast ductal carcinoma in situ (DCIS).Patients and MethodsWe retrospectively assessed eighteen patients with 23 histologically confirmed lesions (mean age, 52.4 ± 10.5 years). All patients were clinically and mammographically examined prior to MRI examination.ResultsDCIS appeared most frequently as non-mass-like lesions (12 lesions, 52.17%). The differences in the frequency of lesion types were statistically significant (P<0.05). The following morphological patterns were detected: A: no specific morphologic features, B: linear/branching enhancement, C: focal mass-like enhancement, D: segmental enhancement, E: segmental enhancement in triangular shape, F: diffuse enhancement, G: regional heterogeneous enhancement in one quadrant not conforming to duct distribution and H: dotted or granular type of enhancement with patchy distribution. The difference in the frequency of the proposed patterns was statistically significant (P<0.05). There were eight lesions with mass enhancement, and six with segmental lesions: regional and triangular. There was no statistically significant difference in the frequency of enhancement curve types (P>0.05). There was no significant difference in the frequency of morpho-kinetic patterns.ConclusionNon-mass-like lesions, lesions with focal or segmental distribution, with a “plateau” enhancement curve type were the most frequent findings of DCIS lesions on MRI.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Breast Ductal Carcinoma in Situ (DCIS): Morphologic and Kinetic MRI Findings

2013

View full text Add to dashboard Cite

show abstract

“…Because SBC occurs more frequently in young woman, mammography may have a diagnostic limitation because of the relatively high density of the breast tissue. A retroareolar dense mass is the usual finding in children as well as in male patients [12][13][14] .…”

Section: Discussionmentioning

confidence: 99%

Secretory breast carcinoma in adulthood: A case report with literature review

et al. 2020

View full text Add to dashboard Cite

Introduction. Secretory breast carcinoma is rare subtype of breast carcinoma which occurs primarily in children and young adults, so in the past it was called juvenile carcinoma. Case report. A 67-year-old female patient presented with mass of the right breast since one month. After physical, routine laboratory examination and mammography, core needle biopsy was performed and histopathological examination confirmed invasive carcinoma. Immunohistochemically, estrogen-receptors (ER) and progesteron-receptors (PR) showed weak positive reaction in 10% of tumor cells, while human epidermal growth factor receptor-2 (HER-2) was without expression. After an adequate preoperative preparation, operation was done -quadrantectomy with sentinel lymph node biopsy. Postoperatively, the patient was treated with 6 cycles of cyclophosphamide, methotrexate and fluorouracil (CMF) combination, radiotherapy (60 Gy) and tamoxifen. After 5-year follow-up the patient had no signs of the disease. Conclusion. Secretory breast cancer is a rare subtype of invasive breast carcinoma with wide age range of occurrence and good prognosis despite its triplenegative immunophenotype. Although the therapeutic management is non-consensual for this breast cancer special type, surgery is considered the mainstay of the treatment as well as the adjuvant chemotherapy and radiation.Key words: breast neoplasms; secretory breast carcinoma; triple negative breast neoplasms; diagnosis; mastectomy, segmental; adult. ApstraktUvod. Sekretorni karcinom dojke je redak tip karcinoma dojke koji se prvenstveno javlja kod dece i mlađih odraslih osoba, zbog čega se u prošlosti nazivao juvenilnim karcinomom. Prikaz bolesnika. Žena, starosti 67 godina, javila se zbog palpabilne, bezbolne mase u desnoj dojci, koja se javila mesec dana pre prijema. Nakon fizikalnog pregleda, rutinskih laboratorijskih analiza i mamografije, načinjena je iglena biopsija i patohistološkom analizom dijagnostikovan je invazivni karcinom dojke. Imunohistohemijski, 10% tumorskih ćelija je pokazalo slabu pozitivnost na estrogenske i progesteronske receptore, dok je receptor humanog epidermalnog faktora rasta-2 (HER-2) bio negativan. Posle adekvatne preoperativne pripreme, izvršen je opertivni zahvatkvadrantektomija sa biopsijom limfnog čvora stražara. Postoperativno, bolesnik je tertiran kombinacijom ciklofosfamid/metrotreksat/fluorouracil (6 ciklusa), radioterapijom (60 Gy) i tamoksifenom. Petogodišnjim praćenjem bolesnice nisu ustanovljeni znaci bolesti. Zaključak. Sekretorni karcinom dojke je redak tip karcinoma dojke, koji zahvata sve starosne grupe i ima dobru prognozu bez obzira na karakteristični tripl-negativni fenotip. Iako ne postoji standardizovan protokol lečenja, hirurška resekcija uz adjuvantnu hemoterapiju i zračnu terapiju su glavni terapijski postupci za ovaj tip karcinoma dojke.

show abstract

Magnetic resonance imaging of the breasts: Clinical practice and further development

Cited by 2 publications

References 13 publications

Breast Ductal Carcinoma in Situ (DCIS): Morphologic and Kinetic MRI Findings

Breast Ductal Carcinoma in Situ (DCIS): Morphologic and Kinetic MRI Findings

Secretory breast carcinoma in adulthood: A case report with literature review

Contact Info

Product

Resources

About