Magnetic Resonance Imaging patterns in central nervous system lymphomas: A pictorial review

Voultsinou, Despoina; Mantatzis, Michalis; Gerukis, Triantafillos; Heva, Angeliki; Birbilis, Theodosios; Prassopoulos, Panos

doi:10.1016/j.clinimag.2021.02.014

Cited by 6 publications

(9 citation statements)

References 26 publications

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“…We found an inverse correlation between tumor [18F]FDG uptake and volume on baseline PET and the ADC value on MRI. Previous studies have described the high cellularity of PCNSL on diffusion-weighted imaging but only Zhou et al previously reported an inverse correlation between ADC and uptake intensity in a cohort of 28 patients [31][32][33]. In our study, we also observed a positive correlation between cerebral blood flow measured using ASL perfusion and [18F]FDG PET uptake, which to our knowledge, has not been reported in the literature.…”

Section: Discussionsupporting

confidence: 67%

“…The high sensitivity of the PET-MRI system equipped new generation silicon photomultiplier detectors, the quantification of delayed PET images acquired between 90 and 110 min post-injection (to increase tumor contrast) and different methods for quantifying the ratios between studies (using either SUVmean or SUVmax as for uptake reference) may explained these differences with previous published data and limit direct comparison with prior studies [30]. Rapid regression of primary brain lymphomas under corticosteroid therapy has been reported in a number of cases on MRI [31]. For [18F]FDG PET, studies on corticosteroid's impact have been conducted on small sample sizes with contradictory results and interestingly, our study showed no impact of corticosteroids on PET measurements.…”

Section: Discussionmentioning

confidence: 99%

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[18F]FDG PET-MRI provides survival biomarkers in primary central nervous system lymphoma in the elderly: an ancillary study from the BLOCAGE trial of the LOC network

Rozenblum,

Galanaud,

Houillier

et al. 2023

Eur J Nucl Med Mol Imaging

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

[18F]FDG PET-MRI provides survival biomarkers in primary central nervous system lymphoma in the elderly: an ancillary study from the BLOCAGE trial of the LOC network

Rozenblum,

Galanaud,

Houillier

et al. 2023

Eur J Nucl Med Mol Imaging

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“…Markedly T2 hyperintense lesions on long TR images and lack of enhancement on T1 images are common. Brain CT reveals changes suggestive of ischemic lesions in most cases [14, 19, 20]. In cases #1, #3, and #4, brain MRI showed multiple cerebral hyperintense white matter lesions in both hemispheres on T2‐weighted sequences.…”

Section: Discussionmentioning

confidence: 99%

“…Changes observed on EEG in IVLBCL are not specific [14]. In changes suggestive of ischemic lesions in most cases [14,19,20].…”

Section: Discussionmentioning

confidence: 99%

Rapidly progressive dementia due to intravascular lymphoma: A prion disease reference center experience

Bentivenga,

Baiardi,

Righini

et al. 2023

Euro J of Neurology

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BackgroundIntravascular large B‐cell lymphoma (IVLBCL) is a rare extranodal lymphoma that is characterized by the selective growth of neoplastic cells in blood vessels, representing a potentially treatable cause of rapidly progressive dementia (RPD). Given its diverse clinical and instrumental presentation, it is often misdiagnosed with more common RPD causes, for example, Creutzfeldt‐Jakob disease (CJD) or vascular dementia.MethodsThis study presents the clinical and histopathological characteristics of four IVLBCL cases that we diagnosed post‐mortem over 20 years among over 600 brain samples received as suspected CJD cases at our prion disease reference center.ResultsOur patients exhibited various presenting symptoms, including behavioral disturbances, disorientation, and alertness fluctuations. The diagnostic tests performed at the time, including blood work, cerebrospinal fluid (CSF) analyses, electroencephalography, and neuroimaging, yielded nonspecific and occasionally misleading results. Consequently, the patients were repeatedly diagnosed as variably having CJD, epilepsy, vascular dementia, and encephalitis. The stored CSF samples of two patients tested negative at prion real‐time quaking‐induced conversion (RT‐QuIC), which we performed afterwards for research purposes. Neuropathological analysis revealed a differential involvement of various brain areas, with frontotemporal neocortices being the most affected.ConclusionsOur results confirm the significant clinical and instrumental heterogeneity of IVLBCL. Neuropathological evidence of the preferential involvement of frontotemporal neocortices, potentially conditioning the clinical phenotype, could be relevant to reach an early diagnosis. Finally, given the therapeutic implications of its misdiagnosis with CJD, we emphasize the utility of prion RT‐QuIC as a test for ruling out CJD in these patients.

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“…Intravascular lymphoma (IVL) is a rare form of large B-cell non-Hodgkin's lymphoma that is prone to the central nervous system (CNS) vascular invasion and occlusion, often resulting in non-localized neuropathy and altered mental status [1] . The diagnosis of IVL is challenging because its clinical presentation and laboratory and imaging findings are nonspecific [2] , [3] , [4] , [5] . We report a case of IVL presenting as a lesion in the splenium of the corpus callosum at the onset.…”

Section: Introductionmentioning

confidence: 99%

A case of intravascular lymphoma presenting with a lesion in the splenium of the corpus callosum

Masuzawa

Suzuki

Amemiya

et al. 2023

Radiology Case Reports

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Magnetic Resonance Imaging patterns in central nervous system lymphomas: A pictorial review

Cited by 6 publications

References 26 publications

[18F]FDG PET-MRI provides survival biomarkers in primary central nervous system lymphoma in the elderly: an ancillary study from the BLOCAGE trial of the LOC network

[18F]FDG PET-MRI provides survival biomarkers in primary central nervous system lymphoma in the elderly: an ancillary study from the BLOCAGE trial of the LOC network

Rapidly progressive dementia due to intravascular lymphoma: A prion disease reference center experience

A case of intravascular lymphoma presenting with a lesion in the splenium of the corpus callosum

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