Magnetic resonance imaging spectrum of medulloblastoma

Fruehwald-Pallamar, Julia; Puchner, Stefan B.; Rossi, Andrea; Garrè, Maria Luisa; Cama, Armando; Koelblinger, Claus; Osborn, Anne G.; Thurnher, Majda M.

doi:10.1007/s00234-010-0829-8

Cited by 73 publications

(56 citation statements)

References 27 publications

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“…These results are consistent with data from other published reports. 2,10,19,23,31 Tumor enhancement may be associated with other tumor characteristics. Tynninen et al 33 retrospectively studied microvessel density, tumor proliferation rate, and degree of enhancement in 62 gliomas.…”

Section: Discussionmentioning

confidence: 99%

Differences in vascular endothelial growth factor receptor expression and correlation with the degree of enhancement in medulloblastoma

Hervey-Jumper¹,

Garton²,

Lau³

et al. 2014

PED

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Object Vascular endothelial growth factor (VEGF) is the major proangiogenic factor in many solid tumors. Vascular endothelial growth factor receptor (VEGFR) is expressed in abundance in pediatric patients with medulloblastoma and is associated with tumor metastasis, poor prognosis, and proliferation. Gadolinium enhancement on MRI has been suggested to have prognostic significance for some tumors. The association of VEGF/VEGFR and Gd enhancement in medulloblastoma has never been closely examined. The authors therefore sought to evaluate whether Gd-enhancing medulloblastomas have higher levels of VEGFR and CD31. Outcomes and survival in patients with enhancing and nonenhancing tumors were also compared. Methods A retrospective analysis of patients with enhancing, nonenhancing, and partially enhancing medulloblastomas was performed. Primary end points included risk stratification, extent of resection, and perioperative complications. A cohort of 3 enhancing and 3 nonenhancing tumors was selected for VEGFR and CD31 analysis as well as microvessel density measurements. Results Fifty-eight patients were analyzed, and 20.7% of the medulloblastomas in these patients were nonenhancing. Enhancing medulloblastomas exhibited strong VEGFR1/2 and CD31 expression relative to nonenhancing tumors. There was no significant difference in perioperative complications or patient survival between the 2 groups. Conclusions These results suggest that in patients with medulloblastoma the presence of enhancement on MRI may correlate with increased vascularity and angiogenesis, but does not correlate with worse patient prognosis in the short or long term.

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Section: Discussionmentioning

confidence: 99%

Differences in vascular endothelial growth factor receptor expression and correlation with the degree of enhancement in medulloblastoma

Hervey-Jumper¹,

Garton²,

Lau³

et al. 2014

PED

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“…In practical terms, the two tumors can usually be distinguished by location and age at presentation. About one half of atypical teratoid/rhabdoid tumors are in the supratentorial compartment whereas medulloblastoma is a posterior fossa tumor; approximately two thirds of infratentorial atypical teratoid/rhabdoid tumors are located in the cerebellopontine angle as opposed to medulloblastomas which, in children, occur in the fourth ventricle in approximately 80% of cases 28 . Age at presentation also differs between the two tumors.…”

Section: Measurement Of Both Adc Values and Nadc For Distinguishing Tmentioning

confidence: 99%

Evaluation of Apparent Diffusion Coefficient Thresholds for Diagnosis of Medulloblastoma Using Diffusion-Weighted Imaging

Pierce

Provenzale

2014

Neuroradiol J

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“…In all variants the enhancement was in most cases intense and homogeneous. 6,9 Very infrequently, MBs involving the CPA may present with widening and deep invasion of the IAC, simulating an acoustic neuroma, or with a dural-based appearance, without bony involvement or hyperostosis, simulating a petrosal meningioma. 12,13,17 In our reported case the tumor had heterogenous hyperintensity on T2 WI and heterogenous enhancement on post contrast scan.…”

Section: Discussionmentioning

confidence: 99%

“…In rare cases they present with ill-defined margins, hypointensity signal on T2, mild or nodular enhancement. [4][5][6] Cerebellopontine angle (CPA) is an uncommon site and only 39 cases have been reported to date in best of our knowledge. We report a further case of CPA MB in a 12 year old female child.…”

Section: Introductionmentioning

confidence: 99%

Medulloblastoma of the Cerebellopontine Angle in a Child: A Rare Entity

Solanki¹,

Ramrakhiani²

2016

IJMRP

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Cerebellopontine (CP) angle Medulloblastoma is a quite uncommon presentation in clinical practice, especially in children. We report such a case in a 12 years old female patient with clinical history of headache, altered sensorium, vertigo, gait ataxia, left side facial paresis and hearing loss. Preoperative axial MR imaging showed an ill-defined heterogenous lesion in left CP angle region with involvement of left middle cerebellar peduncle, left cerebellar hemisphere and cerebellar vermis. Post contrast scan showed heterogenous enhancement. Intra operative frozen cytology was suggestive of malignant round cell neoplasm.The subsequent histopathology and immunohistochemistry favoured the diagnosis of Medulloblastoma.

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Magnetic resonance imaging spectrum of medulloblastoma

Abstract: The results of our study suggest: (a) an age-dependent distribution of MB variants, with DMB and MB-EN more common in younger children; (b) a female predominance in DMB; (c) a more common off-midline location in DMB (50%) and MB-EN (33%) variants.

Cited by 73 publications

References 27 publications

Differences in vascular endothelial growth factor receptor expression and correlation with the degree of enhancement in medulloblastoma

Differences in vascular endothelial growth factor receptor expression and correlation with the degree of enhancement in medulloblastoma

Evaluation of Apparent Diffusion Coefficient Thresholds for Diagnosis of Medulloblastoma Using Diffusion-Weighted Imaging

Medulloblastoma of the Cerebellopontine Angle in a Child: A Rare Entity

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