Magnetic Resonance Imaging Studies of Neurodegenerative Disease: From Methods to Translational Research

Huang, Peiyu; Zhang, Minming

doi:10.1007/s12264-022-00905-x

Cited by 8 publications

(3 citation statements)

References 160 publications

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“…The brain, composed of highly differentiated tissues with limited regenerative capacity for neurons, akin to postmitotic cells, is particularly susceptible to sclerosis and neurodegenerative changes. This susceptibility is evidenced by the frequent detection of neurodegenerative areas in the brains of individuals who do not exhibit symptoms of canonical central nervous system diseases, as revealed through MRI [ 207 , 208 ]. However, only a subset of these individuals will progress to canonical neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease.…”

Section: Local Phenomena Of Low-grade Inflammation In Lc and Other Vi...mentioning

confidence: 99%

Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement

Gusev,

Sarapultsev

2024

IJMS

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Long COVID (LC), also referred to as Post COVID-19 Condition, Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), and other terms, represents a complex multisystem disease persisting after the acute phase of COVID-19. Characterized by a myriad of symptoms across different organ systems, LC presents significant diagnostic and management challenges. Central to the disorder is the role of low-grade inflammation, a non-classical inflammatory response that contributes to the chronicity and diversity of symptoms observed. This review explores the pathophysiological underpinnings of LC, emphasizing the importance of low-grade inflammation as a core component. By delineating the pathogenetic relationships and clinical manifestations of LC, this article highlights the necessity for an integrated approach that employs both personalized medicine and standardized protocols aimed at mitigating long-term consequences. The insights gained not only enhance our understanding of LC but also inform the development of therapeutic strategies that could be applicable to other chronic conditions with similar pathophysiological features.

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Section: Local Phenomena Of Low-grade Inflammation In Lc and Other Vi...mentioning

confidence: 99%

Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement

Gusev,

Sarapultsev

2024

IJMS

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“…In AD-suspected patients, MRI allows for non-invasive measurement of the brain tissue volume, which helps to localize pathophysiological signs such as regional brain atrophy, gray matter volume loss, and white matter damage [ 15 , 34 , 35 , 81 ]. However, these signs are not specific signatures of AD, and the number of brain cells or white matter tracts that should be lost to detect atrophy in AD is unknown [ 15 ].…”

Section: Major Amyloid Visualization Techniquesmentioning

confidence: 99%

Molecular Design of Magnetic Resonance Imaging Agents Binding to Amyloid Deposits

Nikiforova

Sedov

2023

IJMS

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The ability to detect and monitor amyloid deposition in the brain using non-invasive imaging techniques provides valuable insights into the early diagnosis and progression of Alzheimer’s disease and helps to evaluate the efficacy of potential treatments. Magnetic resonance imaging (MRI) is a widely available technique offering high-spatial-resolution imaging. It can be used to visualize amyloid deposits with the help of amyloid-binding diagnostic agents injected into the body. In recent years, a number of amyloid-targeted MRI probes have been developed, but none of them has entered clinical practice. We review the advances in the field and deduce the requirements for the molecular structure and properties of a diagnostic probe candidate. These requirements make up the base for the rational design of MRI-active small molecules targeting amyloid deposits. Particular attention is paid to the novel cryo-EM structures of the fibril aggregates and their complexes, with known binders offering the possibility to use computational structure-based design methods. With continued research and development, MRI probes may revolutionize the diagnosis and treatment of neurodegenerative diseases, ultimately improving the lives of millions of people worldwide.

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“…MRI is, possibly, the most versatile medical imaging technique available both at clinical and preclinical levels. Its noninvasiveness, image quality (in terms of image resolution and contrast generation), and multimodality allow detailed brain imaging at structural, vascular, metabolic, and functional levels 9 . In the field of AD, MRI is used to assess changes in brain structure, allowing the study of brain atrophy, 10 detecting events that may explain nondegenerative cognitive impairment, 11 and providing information about the integrity of white matter and neuronal circuits through all variants of diffusion‐weighted imaging (e.g., diffusion‐weighted imaging, diffusion tension imaging, diffusion kurtosis imaging, fiber tracking, neurite orientation dispersion, and density imaging, soma and neurite density imaging, etc 12 …”

Section: Neuroimaging From Cellular To Full System Level In Admentioning

confidence: 99%

Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI)

Liu,

van Beusekom,

et al. 2023

Neuroprotection

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The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease (AD) and associated socioeconomic burdens. Abnormal metabolism of amyloid‐β (Aβ) has been proposed as a significant pathomechanism in AD, supported by results of recent clinical trials using anti‐Aβ antibodies. Nonetheless, the cognitive benefits of the current treatments are limited. The etiology of AD is multifactorial, encompassing Aβ and tau accumulation, neuroinflammation, demyelination, vascular dysfunction, and comorbidities, which collectively lead to widespread neurodegeneration in the brain and cognitive impairment. Hence, solely removing Aβ from the brain may be insufficient to combat neurodegeneration and preserve cognition. To attain effective treatment for AD, it is necessary to (1) conduct extensive research on various mechanisms that cause neurodegeneration, including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level; (2) identify neuroprotective intervention targets against different neurodegeneration mechanisms; and (3) discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD patients. The Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated, multidisciplinary efforts to develop systemic neuroprotective strategies to combat AD. The aim is to achieve mitigation of the full spectrum of pathological processes underlying AD, with the goal of halting or even reversing cognitive decline.

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Magnetic Resonance Imaging Studies of Neurodegenerative Disease: From Methods to Translational Research

Cited by 8 publications

References 160 publications

Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement

Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement

Molecular Design of Magnetic Resonance Imaging Agents Binding to Amyloid Deposits

Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI)

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