Magnetic Resonance Imaging Study of the Cavum Septi Pellucidi in Patients With Schizophrenia

Hagino, Hirofumi; Suzuki, Michio; Kurokawa, Kenzou; Mori, Kouichi; Nohara, Shigeru; Takahashi, Tsutomu; Yamashita, Iwao; Yotsutsuji, Takashi; Kurachi, Masayoshi; Seto, Hikaru

doi:10.1176/appi.ajp.158.10.1717

Cited by 35 publications

(37 citation statements)

References 12 publications

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“…These findings are consistent with recent high-resolution MRI studies (Fukuzako et al, 1996;Hagino et al, 2001;Kwon et al, 1998;Nopoulos et al, 1997;Rajarethinam et al, 2001), and further suggest that a small CSP is a normal anatomical variant. In contrast, the prevalence of abnormal CSP (approximately 6 mm or longer) was higher for first-episode schizophrenic patients than for the control subjects, in line with recent studies Nopoulos et al, 1997;Shioiri et al, 1996).…”

Section: Discussionsupporting

confidence: 91%

“…From the results of recent high-spatial-resolution MRI studies (Fukuzako et al, 1996;Hagino et al, 2001;Kwon et al, 1998;Nopoulos et al, 1997;Rajarethinam et al, 2001) that report high prevalence of CSP (38.0-84.8%) in adults, it is clear that the presence of a very small CSP may have no pathological significance. Therefore, it was necessary to distinguish CSP that were considered to be larger than the normal variant CSP.…”

Section: Csp Measuresmentioning

confidence: 99%

“…Of further note, out of nine independent research studies investigating the prevalence and/or qualifying the rate of abnormal CSP in patients with schizophrenia compared with normal subjects using MRI (Degreef et al, 1992;DeLisi et al, 1993;Fukuzako et al, 1996;Hagino et al, 2001;Jurjus et al, 1993;Kwon et al, 1998;Nopoulos et al, 1997;Rajarethinam et al, 2001;Shioiri et al, 1996), six reported positive findings (Degreef et al, 1992;DeLisi et al, 1993;Kwon et al, 1998;Nopoulos et al, 1997;Rajarethinam et al, 2001;Shioiri et al, 1996). It is not clear, however, what the relationship of CSP findings is to clinical characteristics and abnormalities in limbic structures in patients with schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

“…Incomplete fusion results in the persistence of a CSP, which reflects possible neurodevelopmental abnormalities of these midline and limbic structures (Rakic and Yakovlev, 1968;Sarwar, 1989;Shaw and Alvord, 1969). Particularly noteworthy, however, are recent high-spatialresolution MRI studies (Fukuzako et al, 1996;Hagino et al, 2001;Kwon et al, 1998;Nopoulos et al, 1997;Rajarethinam et al, 2001) that tend to report a higher prevalence of CSP (38.0-84.8%) in normal adults than previous MRI studies with lower spatial resolution (1.1-29.8%) (Degreef et al, 1992;DeLisi et al, 1993;Jurjus et al, 1993;Shioiri et al, 1996). These more recent in vivo MRI studies suggest that a small CSP is likely a normal variant.…”

Section: Introductionmentioning

confidence: 99%

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Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study

Kasai

McCarley

Salisbury

et al. 2004

Schizophrenia Research

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A high prevalence of abnormal cavum septi pellucidi (CSP) in schizophrenia may reflect neurodevelopmental abnormalities in midline structures of the brain. The relationship, however, between abnormal CSP and clinical symptoms, and with abnormalities in other limbic structures remains unclear, as does the question of whether a similar abnormality is present in affective psychosis. Seventy-four patients at their first hospitalization, 33 with schizophrenia and 41 with affective (mainly manic) psychosis, and 56 healthy control subjects underwent high-spatialresolution magnetic resonance imaging (MRI). CSP on six slices or more on 0.9375-mm resampled coronal images was categorized as abnormal. The prevalence of abnormal CSP in both schizophrenic patients (26.1%) and affective psychosis patients (18.2%) was significantly higher than was observed in control subjects (8.2%). In schizophrenic patients only, larger CSP was significantly associated with more severe thinking disturbance and smaller left parahippocampal gyrus gray matter volumes. While the relationships between CSP ratings and clinical symptoms did not significantly differ between the two psychosis groups as assessed by the comparison of regression slopes, the association with limbic volumes appeared to be specific to schizophrenic patients. These results suggest that psychosis associated with schizophrenia and affective disorder share, at least to some extent, neurodevelopmental abnormalities involving midline structures and associated psychopathological consequences. However, the association between abnormal CSP and limbic systems may be more specific to schizophrenia.

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Section: Discussionsupporting

confidence: 91%

Section: Csp Measuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study

Kasai

McCarley

Salisbury

et al. 2004

Schizophrenia Research

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“…Since the images were 1-mm thick without gaps, the rating reflected the actual anterior-to-posterior length of the CSP. CSPs spanning 6 or more slices were defined as large (12). A CSP visualized in 1 or more slices was defined as present (2,11).…”

mentioning

confidence: 99%

The size and prevalence of the cavum septum pellucidum are normal in subjects with panic disorder

Crippa

Uchida

Busatto

et al. 2004

Braz J Med Biol Res

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Panic disorder is thought to involve dysfunction in the septohippocampal system, and the presence of a cavum septum pellucidum might indicate the aberrant development of this system. We compared the prevalence and size of cavum septum pellucidum in 21 patients with panic disorder and in 21 healthy controls by magnetic resonance imaging. The length of the cavum septum pellucidum was measured by counting the number of consecutive 1-mm coronal slices in which it appeared. A cavum septum pellucidum of >6 mm in length was rated as large. There was no significant difference in the proportion of patients (16 of 21 or 76.2%) and controls (18 of 21 or 85.7%) with a cavum septum pellucidum (P = 0.35, Fisher's exact test, one-tailed), and no members of either group had a large cavum septum pellucidum. The mean cavum septum pellucidum rating in the patient and control groups was 1.81 (SD = 1.50) and 2.09 (SD = 1.51), respectively. There were also no significant differences between groups when we analyzed cavum septum pellucidum ratings as a continuous variable (U = 196.5; P = 0.54). Across all subjects there was a trend towards a higher prevalence of cavum septum pellucidum in males (100%, 10 of 10) than females (75%, 24 of 32; P = 0.09, Fisher's exact test, one-tailed). Thus, we conclude that, while panic disorder may involve septohippocampal dysfunction, it is not associated with an increased prevalence or size of the cavum septum pellucidum. Correspondence

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Linear parameters of normal and abnormal cava septi pellucidi: A post‐mortem study

Filipović

Teofilovski-Parapid

2004

Clinical Anatomy

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Anatomical variations in the dimensions of different brain structures have been correlated with clinical syndromes. This study on the parameters of normal and abnormal cavum septi pellucidi (CSP) can be of clinical significance. We obtained 479 brains from autopsied persons (310 males and 169 females, 377 normal or asymptomatic and 102 abnormal or symptomatic persons, aged 22-89 years) and observed that 110 brains (75 males and 35 females) had CSP. These cava were classified into two groups depending on the past medical histories of the autopsied person: 40 asymptomatic and 70 symptomatic cava. We have defined symptomatic cava as those in autopsied persons who had known past medical history of psychiatric or neurological disease. Asymptomatic cava were in autopsied persons who had no known past medical history of psychiatric or neurological disease. The CSP parameters (length, width, depth) of the symptomatic and asymptomatic groups were measured and were statistically analyzed. Analysis showed that the cava in the symptomatic group were significantly longer and wider. Discriminant function analysis was used to derive a mathematical formula to classify CSP into an asymptomatic or symptomatic group based on length and width measurements of the cavum.

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Magnetic Resonance Imaging Study of the Cavum Septi Pellucidi in Patients With Schizophrenia

Abstract: The findings support the idea that a small CSP is a normal anatomical variant. More cases of a large CSP are needed to elucidate the implications of this abnormality in schizophrenia.

Cited by 35 publications

References 12 publications

Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study

Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study

The size and prevalence of the cavum septum pellucidum are normal in subjects with panic disorder

Linear parameters of normal and abnormal cava septi pellucidi: A post‐mortem study

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