Magnetic resonance imaging with liver-specific contrast agent in primary amyloidosis and intrahepatic cholestasis

Møller, Jakob M.; Santoni-Rugiu, Eric; Chabanova, Elizaveta; Løgager, Vibeke; Hansen, Alastair; Thomsen, Henrik S.

doi:10.1080/02841850601128959

Cited by 10 publications

(2 citation statements)

References 16 publications

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“…Hepatic signs and symptoms are usually limited to elevated liver enzymes and hepatomegaly with or without portal hypertension [9]. Ultrasound [10], computed tomography [11,12], and magnetic resonance imaging [13] are not able to make a specific diagnosis of amyloidosis. In the absence of pathognomonic imaging characteristics, the confirmation of amyloidosis often requires tissue biopsy.…”

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confidence: 99%

Amyloidosis of the liver on shear wave elastography: case report and review of literature

et al. 2015

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Amyloidosis is extremely rare, with an estimated 2225 new US cases reported annually. Signs and symptoms of the disease are subtle and imaging findings are not pathognomonic. Currently, diagnosis requires biopsy to demonstrate the deposition of amyloid. Elastography is a new imaging modality that evaluates tissue elasticity. It has shown to have efficacy in characterizing thyroid nodules, detecting prostate cancer, and staging liver fibrosis. We present a case of hepatic amyloidosis in a 51-year-old male that demonstrates significantly increased stiffness with a median value of 99.1 kPa (range 25.7-188.9 kPa) on shear-wave elastography (SWE) imaging, which is significantly higher than the cut-off range reported for cirrhosis on SWE (10.4-11.5 kPa). This finding raises the possibility that elastographic imaging may be sensitive to tissue mechanical changes induced by amyloid deposition.

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confidence: 99%

Amyloidosis of the liver on shear wave elastography: case report and review of literature

et al. 2015

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“…Only MRI with a manganese-containing contrast agent revealed some focal areas without contrast uptake in the hepatocytes and no bile secretion after 8 hours. Afterwards, a liver biopsy showed parenchymal amyloidosis [53]. Bandyopadhyay et al report on a case with hepatic involvement in primary amyloidosis that presented with mild hepatomegaly and cholestasis [54].…”

Section: Liver Hepatobiliary System Lymph Nodes and Spleenmentioning

confidence: 99%