Magnetic resonance lymphography of sentinel lymph nodes in patients with breast cancer using superparamagnetic iron oxide: a feasibility study

Shiozawa, Mikio; Kobayashi, Shigeru; Sato, Yuichi; Maeshima, Hiroyuki; Hozumi, Yasuo; Lefor, Alan Kawarai; Kurihara, Kei; Sata, Naohiro; Yasuda, Yoshikazu

doi:10.1007/s12282-012-0401-y

Cited by 23 publications

(19 citation statements)

References 18 publications

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“…[11][12][13][14][15] However, these studies still rely on the use of radioisotopes for intraoperative detection of the sentinel nodes. Shiozawa et al 16 was the first to present an entirely radioisotope-free procedure, using SPIO MRI for pre-operative localization and a handheld magnetometer for intraoperative detection of SLNs. They successfully identified SLNs with MRI in nine of nine patients; however, MRI only predicted the number of SLNs accurately in three of nine (33%) patients.…”

Section: Discussionmentioning

confidence: 99%

“…We achieved a concordance between the number of nodes identified by imaging and during surgery of 55%, equal to the combined technique. Shiozawa et al 16 used a different, possibly less sensitive, magnetometer which could explain this difference.…”

Section: Discussionmentioning

confidence: 99%

“…However, all these studies still rely on the use of radioisotopes for intraoperative detection of the sentinel nodes. [11][12][13][14][15] To date, only one study 16 has involved both pre-operative SPIO MRI and intraoperative SLN detection with a handheld magnetometer in nine patients. However, this study did not compare the MRI technique with the gold standard of the combined technique.…”

Section: Introductionmentioning

confidence: 99%

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Pre-operative sentinel lymph node localization in breast cancer with superparamagnetic iron oxide MRI: the SentiMAG Multicentre Trial imaging subprotocol

Pouw

Grootendorst

Bezooijen

et al. 2015

BJR

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pre-operative sentinel lymph node localization in breast cancer with superparamagnetic iron oxide MRI: the SentiMAG Multicentre Trial imaging subprotocol

Pouw

Grootendorst

Bezooijen

et al. 2015

BJR

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show abstract

“…SLN biopsy is now considered as the standard of care in patients without clinical and/or radiological evidence of axillary lymph node metastases in early-stage breast cancer. 51 Shiozawa et al 52 conducted the first integrated study to evaluate SPIO both as a contrast material in MR sentinel lymphography and as a tracer in SLN biopsy. Their resulting three-dimensional imaging had excellent image quality and allowed for the identification of SLN in conjunction with SLN biopsy.…”

Section: Using Spion In Cancer Imaging Applicationsmentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles for MR imaging of pancreatic cancer: Potential for early diagnosis through targeted strategies

Zhang¹,

Zou²,

Chen³

et al. 2015

Asia-Pac J Clncl Oncology

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Superparamagnetic iron oxide nanoparticles (SPION)-based magnetic resonance imaging is a powerful, noninvasive tool in biomedical imaging. The recent embedding of SPIO in nanoencapsulations that had different controllable surface properties has now made it possible to use SPIO in the imaging of metabolic processes. The two major issues to realize maximized and selective SPIO cancer targeting are the minimization of macrophage uptake and the preferential binding to cancerous cells over healthy neighbor cells. The utility of SPIO has been shown in clinical applications using a series of marketed SPION-based contrast agents. Applications have ranged from detecting inflammatory diseases to the specific identification of cell surface markers expressed on tumors. This review focuses on iron-oxide-based nanoparticles, to include the physiochemical properties of SPION surface engineering and its synthetic methods as well as SPIO imaging applications and specifically targeted SPIO conjugates (e.g. targeted probes) for labeling cancerous, cell-surface molecules. As a specific application of this technology, we discuss its use in the imaging of pancreatic duct adenocarcinoma in addition to its potential for use in early diagnosis through targeted strategies.

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“…In the last decade, several studies have been published about the application of magnetic nanoparticles (MNPs) for sentinel lymph node biopsy (SLNB) [3][4][5][6][7][8]1,2]. Especially the disadvantages accompanying the usually applied radionuclides in SLNB, concerning radiation exposure, complicated logistics and legislation, have stimulated the search for other tracers and detection methods, leading to the introduction of MNPs in SLNB.…”

Section: Introductionmentioning

confidence: 99%

Depth limitations for in vivo magnetic nanoparticle detection with a compact handheld device

Visscher

Waanders

Pouw

et al. 2015

Journal of Magnetism and Magnetic Materials

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a b s t r a c tThe increasing interest for local detection of magnetic nanoparticles (MNPs) during clinical interventions requires the development of suitable probes that unambiguously detect the MNPs at a depth of several centimeters in the body. The present study quantitatively evaluates the limitations of a conventional magnetometry method using a sinusoidal alternating field. This method is limited by the variability of the magnetic susceptibility of the surrounding diamagnetic tissue. Two different sensors are evaluated in a theoretical model of MNP detection in a tissue volume. For a coil that completely encloses the sample volume, the MNPs can be detected if the total mass contributing to the signal is larger than 4.1 10 7 × − times the tissue mass. For a handheld surface coil, intended to search for the MNPs in a larger tissue volume, an amount of 1 μg of iron oxide cannot be detected by sensors with a diameter larger than 15 mm. To detect a spot with MNPs at 5 cm depth in tissue, it should contain at least 325 μg iron oxide.Therefore, for high-sensitive clinical MNP detection in surgical interventions, techniques with increased specificity for the nonlinear magnetic properties of MNPs are indispensable.

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Magnetic resonance lymphography of sentinel lymph nodes in patients with breast cancer using superparamagnetic iron oxide: a feasibility study

Cited by 23 publications

References 18 publications

Pre-operative sentinel lymph node localization in breast cancer with superparamagnetic iron oxide MRI: the SentiMAG Multicentre Trial imaging subprotocol

Pre-operative sentinel lymph node localization in breast cancer with superparamagnetic iron oxide MRI: the SentiMAG Multicentre Trial imaging subprotocol

Superparamagnetic iron oxide nanoparticles for MR imaging of pancreatic cancer: Potential for early diagnosis through targeted strategies

Depth limitations for in vivo magnetic nanoparticle detection with a compact handheld device

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