Magnetic resonance (MR) imaging for tumor staging and definition of tumor volumes on radiation treatment planning in nonsmall cell lung cancer

Abstract

We investigate the impact of magnetic resonance (MR) on the staging and radiotherapy planning for patients with nonsmall cell lung cancer (NSCLC).A total of 24 patients with NSCLC underwent MRI, which was fused with radiotherapy planning CT using rigid registration. Gross tumor volume (GTV) was delineated not only according to CT image alone (GTVCT), but also based on both CT and MR image (GTVCT/MR). For each patient, 2 conformal treatment plans were made according to GTVCT and GTVCT/MR, respectively. Dose-volume histograms (DVH) for lesion and normal organs were generated using both GTVCT and GTVCT/MR treatment plans. All patients were irradiated according to GTVCT/MR plan.Median volume of the GTVCT/MR and GTVCT were 105.42 cm3 and 124.45 cm3, respectively, and the mean value of GTVCT/MR was significantly smaller than that of GTVCT (145.71 ± 145.04 vs 174.30 ± 150.34, P < 0.01). Clinical stage was modified in 9 patients (37.5%). The objective response rate (ORR) was 83.3% and the l-year overall survival (OS) was 87.5%.MR is a useful tool in radiotherapy treatment planning for NSCLC, which improves the definition of tumor volume, reduces organs at risk dose and does not increase the local recurrence rate.

Measurements of target volumes and organs at risk using DW‑MRI in patients with central lung cancer accompanied with atelectasis

“…DW-MRI has become an indispensable tool in cancer research, diagnosis and treatment, and it has been suggested that DWI combined with MRI can provide important information in differentiating lung cancer and atelectasis ( 41 ).…”

“…Deniaud-Alexandre et al (40) revealed that PET/CT can provide different GTVs from the traditional CT plan in patients with non-small cell lung cancer and can also change the estimated receiving dosage of heart and lungs. DW-MRI has become an indispensable tool in cancer research, diagnosis and treatment, and it has been suggested that DWI combined with MRI can provide important information in differentiating lung cancer and atelectasis (41).…”

A Multifunctional AIE Nanoprobe as a Drug Delivery Bioimaging and Cancer Treatment System

“…At present, most drug delivery systems can only deliver drugs to cancer cells, and the distribution and release of drug delivery systems in cancer cells cannot be monitored. In order to further develop and optimize drug delivery systems, a multifunctional nanomedicine platform for imaging diagnosis and therapy is needed ( Zhao et al, 2017 ; Wang et al, 2020 ). The usual approach is to integrate fluorescent dyes into the drug delivery system.…”