Magnetic Resonance Neurography for Evaluation of Dorsal Root Ganglion Morphology

Wang, Hongwei; Li, Kaixiang; Qing-yun, Wang; Liu, Xiaoqiang; Zhao, Xiangjun; Zhong, Zhanghua; Gu, Cheng; Li, Ruibin

doi:10.1016/j.wneu.2021.06.123

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Magnetic resonance imaging (MRI) is an irreplaceable technique for visualizing peripheral nerves and their pathological changes vividly [13]. Several MRI studies have been carried out to conduct morphological analysis and quantitative diffusion imaging of the DRG [14][15][16]. A recent study evaluated the correlation between clinical symptoms and morphological features of the dorsal root ganglion in patients with PHN using MRN technology [17].…”

Section: Introductionmentioning

confidence: 99%

Diffusion-Weighted Imaging of the Dorsal Root Ganglion as a Quantitative Biomarker Reflecting the Severity and Prognosis of Herpes Zoster:A Prospective Magnetic Resonance Imaging Study

Shen,

Dai,

Liu

et al. 2024

Preprint

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Section: Introductionmentioning

confidence: 99%

Diffusion-Weighted Imaging of the Dorsal Root Ganglion as a Quantitative Biomarker Reflecting the Severity and Prognosis of Herpes Zoster:A Prospective Magnetic Resonance Imaging Study

Shen,

Dai,

Liu

et al. 2024

Preprint

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“…The DRG volume may be measured using different methods in a 3D MR neurography sequence [ 13 , 14 , 15 ]. Exact volumetry is based on 3D segmentation of the whole DRG and requires manual segmentation of the DRG contours in multiple slices.…”

Section: Introductionmentioning

confidence: 99%

Dorsal Root Ganglia Volume—Normative Values, Correlation with Demographic Determinants and Reliability of Three Different Methods of Volumetry

et al. 2022

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Background: Dorsal root ganglia (DRG) volume assessment by MR-Neurography (MRN) has evolved to an important imaging marker in the diagnostic workup of various peripheral neuropathies and pain syndromes. The aim of this study was (1) to assess normal values of DRG volume and correlations with demographic determinants and (2) to quantify the inter-reader and inter-method reliability of three different methods of DRG volumetry. Methods: Sixty healthy subjects (mean age: 59.1, range 23–79) were examined using a 3D T2-weighted MRN of the lumbosacral plexus at 3 Tesla. Normal values of DRG L3 to S2 were obtained after exact volumetry based on manual 3D segmentation and correlations with demographic variables were assessed. For the assessment of inter-reader and inter-method reliability, DRG volumes in a subset of 25 participants were measured by two independent readers, each applying (1) exact volumetry based on 3D segmentation, (2) axis-corrected, and (3) non-axis-corrected volume estimation. Intraclass correlation coefficients were reported and the Bland–Altman analysis was conducted. Results: Mean DRG volumes ranged from 124.8 mm3 for L3 to 323.3 mm3 for S1 and did not differ between right and left DRG. DRG volume (mean of L3 to S1) correlated with body height (r = 0.42; p = 0.0008) and weight (r = 0.34; p = 0.0087). DRG of men were larger than of women (p = 0.0002); however, no difference remained after correction for body height. Inter-reader reliability was high for all three methods but best for exact volumetry (ICC = 0.99). While axis-corrected estimation was not associated with a relevant bias, non-axis-corrected estimation systematically overestimated DRG volume by on average of 15.55 mm3 (reader 1) or 18.00 mm3 (reader 2) when compared with exact volumetry. Conclusion: The here presented normal values of lumbosacral DRG volume and the correlations with height and weight may be considered in future disease specific studies and possible clinical applications. Exact volumetry was most reliable and should be considered the gold standard. However, the reliability of axis-corrected and non-axis-corrected volume estimation was also high and might still be sufficient, depending on the degree of the required measurement accuracy.

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Diffusion-weighted imaging of the dorsal root ganglion as a quantitative biomarker reflecting the severity and prognosis of herpes zoster：a prospective magnetic resonance imaging study

Shen,

Dai,

Liu

et al. 2023

Preprint

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This prospective study aimed to characterize diffusion-weighted imaging (DWI) of the dorsal root ganglion (DRG) in herpes zoster (HZ) and to investigate the apparent diffusion coefficient (ADC) as a quantitative evaluation indicator for HZ as well as a predictor for postherpetic neuralgia (PHN). Thirty-six patients with HZ and ten healthy volunteers underwent magnetic resonance imaging (MRI) scanning. The ADC values of the affected and symmetric asymptomatic DRG were collected and compared. The rash intensity (RI), visual analog scale (VAS), pain index (PI), insomnia severity index (ISI), self-rated anxiety scale (SAS) and self-rated depression scale (SDS) were used to assess clinical characteristics. DWI analysis showed that ADC values of symptomatic DRG were significantly lower than those of symmetric asymptomatic DRG in both the HZ-period (P < 0.001) and the follow-up period (P < 0.001). The ADC value difference of the bilateral DRG at the affected segment (asymptomatic value – symptomatic value) was correlated with several clinical data in the HZ period. Analysis of the receiver operating characteristic curve revealed that the HZ-period ADC value difference had a high predictive value for PHN (Area under the curve = 0.815, P = 0.003). The cutoff value was 0.121 × 10–3mm2/s. DWI of the DRG can quantitatively display the change in the affected DRG in HZ patients and may indicate nerve necrosis and structural variation of the neuronal cell membrane. DWI of the DRG can help evaluate the clinical status of patients with HZ and may be a potential prognostic indicator for the occurrence of PHN.

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Magnetic Resonance Neurography for Evaluation of Dorsal Root Ganglion Morphology

Cited by 3 publications

References 26 publications

Diffusion-Weighted Imaging of the Dorsal Root Ganglion as a Quantitative Biomarker Reflecting the Severity and Prognosis of Herpes Zoster:A Prospective Magnetic Resonance Imaging Study

Diffusion-Weighted Imaging of the Dorsal Root Ganglion as a Quantitative Biomarker Reflecting the Severity and Prognosis of Herpes Zoster:A Prospective Magnetic Resonance Imaging Study

Dorsal Root Ganglia Volume—Normative Values, Correlation with Demographic Determinants and Reliability of Three Different Methods of Volumetry

Diffusion-weighted imaging of the dorsal root ganglion as a quantitative biomarker reflecting the severity and prognosis of herpes zoster：a prospective magnetic resonance imaging study

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