Magnetic resonance relaxation times of percutaneously obtained normal and abnormal body fluids.

Abstract

Seventy-three fluid samples obtained via percutaneous aspiration and drainage were analyzed by proton magnetic resonance spectroscopy. The fluids included abscess contents, bile, ascitic fluid, cyst and pseudocyst fluid, urine, hematomas, pleural fluid, lymphoceles, seromas, cerebrospinal fluid, pancreatic ductal fluid, and necrotic tumor. They were grouped by their clinical etiology and analyzed with respect to their inherent magnetic relaxation properties. In addition, some of the samples were tested for the following chemical parameters which were correlated with T1 and T2 values: total protein content (n = 36), osmolality (n = 24), specific gravity (n = 11), and amylase levels (n = 23). A large overlap was found in the T1 (spin-lattice) and T2 (spin-spin) relaxation times of the fluids; however, the mean T1 values of abscesses and hematomas were significantly lower than those of other fluids. Similar variability was seen in T2 values, though hematomas and abscesses again could be distinguished by shorter relaxation times. The spin-lattice (1/T1) and spin-spin relaxation rates (1/T2) showed a moderate correlation with total protein content, osmolality, and specific gravity. It is concluded that there is some predictability to MR analysis of body fluids, though the overlap in magnetic relaxation times limits specificity.

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“…Therefore this tumor was thought to contain rich protein or hemorrhage. The rich protein lesions reveal high signal intensity not only T1 weighted image but also T2 weighted image on HR-MR imaging by the concentration of protein 20,21,22 . Dot-like high signal intensities on T1 weighted image and nodular high signal intensities on fat-saturated T2 weighted image of HR-MRI might correspond to the groups of intracellular and extracellular secretory milklike material of the secretory carcinoma ( Figure 3C, 3D, 5C, 5D).…”

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