Magnetic resonance spectroscopy and liquid chromatography-mass spectrometry metabolomics study may differentiate pre-eclampsia from gestational hypertension

Liu, Xuefei; Li, Mengdie; Lu, Jingjing; Li, Ying; Zeng, Anrong; Qiang, Jun

doi:10.1007/s00330-023-09454-x

Cited by 3 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…160 Serum LC-MS metabolomics results showed that metabolites involved in pyruvate metabolism and glycolysis could distinguish preeclampsia from gestational hypertension. 161 The aforementioned studies supported the hypothesis that impaired trophoblast invasion and vascular remodeling reduce oxygen and nutrient transport, cause hypoxia and placental stress, and release factors that precipitate the maternal syndrome. Placental HIF-1α is upregulated in response to hypoxia and accompanied by the upregulation of glycolysis to maintain ATP biosynthesis.…”

Section: Preeclampsiamentioning

confidence: 73%

“…In addition, differential proteomic analysis by 8‐Plex iTRAQ labeling coupled with 2D Nano LC–MS/MS confirmed that differentially expressed proteins were involved in glycolysis/gluconeogenesis in the STB extracellular vesicles of early‐onset severe preeclampsia 160 . Serum LC–MS metabolomics results showed that metabolites involved in pyruvate metabolism and glycolysis could distinguish preeclampsia from gestational hypertension 161 …”

Section: Glycolysis In Pathological Pregnancymentioning

confidence: 91%

See 1 more Smart Citation

Glycolysis: A fork in the path of normal and pathological pregnancy

Gou,

Zhang

2023

The FASEB Journal

View full text Add to dashboard Cite

Glucose metabolism is vital to the survival of living organisms. Since the discovery of the Warburg effect in the 1920s, glycolysis has become a major research area in the field of metabolism. Glycolysis has been extensively studied in the field of cancer and is considered as a promising therapeutic target. However, research on the role of glycolysis in pregnancy is limited. Recent evidence suggests that blastocysts, trophoblasts, decidua, and tumors all acquire metabolic energy at specific stages in a highly similar manner. Glycolysis, carefully controlled throughout pregnancy, maintains a dynamic and coordinated state, so as to maintain the homeostasis of the maternal–fetal interface and ensure normal gestation. In the present review, we investigate metabolic remodeling and the selective propensity of the embryo and placenta for glycolysis. We then address dysregulated glycolysis that occurs in the cellular interactive network at the maternal–fetal interface in miscarriage, preeclampsia, fetal growth restriction, and gestational diabetes mellitus. We provide new insights into the field of maternal–fetal medicine from a metabolic perspective, thus revealing the mystery of human pregnancy.

show abstract

Section: Preeclampsiamentioning

confidence: 73%

Section: Glycolysis In Pathological Pregnancymentioning

confidence: 91%

Glycolysis: A fork in the path of normal and pathological pregnancy

Gou,

Zhang

2023

The FASEB Journal

View full text Add to dashboard Cite

show abstract

“…Furthermore, the literature indicates that immune cell infiltration is closely linked with the incidence of PE. A serum metabolomic analysis found clear differences in GLU metabolism between women with normal pregnancies and those with PE [ 22 ]. Therefore, identifying specific diagnostic indices and elucidating immune cell infiltration in PE could profoundly improve its prognosis.…”

Section: Discussionmentioning

confidence: 99%

Identification of hub glutamine metabolism-associated genes and immune characteristics in pre-eclampsia

Mao,

Li,

Ren

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Objective Preeclampsia (PE) is a severe complication of unclear pathogenesis associated with pregnancy. This research aimed to elucidate the properties of immune cell infiltration and potential biomarkers of PE based on bioinformatics analysis. Materials and methods Two PE datasets were imported from the Gene ExpressioOmnibus (GEO) and screened to identify differentially expressed genes (DEGs). Significant module genes were identified by weighted gene co-expression network analysis (WGCNA). DEGs that interacted with key module genes (GLu-DEGs) were analyzed further by Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses. The diagnostic value of the genes was assessed using receiver operating characteristic (ROC) curves and protein-protein interaction (PPI) networks were constructed using GeneMANIA, and GSVA analysis was performed using the MSigDB database. Immune cell infiltration was analyzed using the TISIDB database, and StarBase and Cytoscape were used to construct an RBP-mRNA network. The identified hub genes were validated in two independent datasets. For further confirmation, placental tissue from healthy pregnant women and women with PE were collected and analyzed using both RT-qPCR and immunohistochemistry. Results A total of seven GLu-DEGs were obtained and were found to be involved in pathways associated with the transport of sulfur compounds, PPAR signaling, and energy metabolism, shown by GO and KEGG analyses. GSVA indicated significant increases in adipocytokine signaling. Furthermore, single-sample Gene Set Enrichment Analysis (ssGSEA) indicated that the levels of activated B cells and T follicular helper cells were significantly increased in the PE group and were negatively correlated with GLu-DEGs, suggesting their potential importance. Conclusion In summary, the results showed a correlation between glutamine metabolism and immune cells, providing new insights into the understandingPE pathogenesis and furnishing evidence for future advances in the treatment of this disease.

show abstract

Commentary: magnetic resonance spectroscopy and liquid chromatography-mass spectrometry metabolomics study may differentiate pre-eclampsia from gestational hypertension

Zhu

2023

Eur Radiol

View full text Add to dashboard Cite

Magnetic resonance spectroscopy and liquid chromatography-mass spectrometry metabolomics study may differentiate pre-eclampsia from gestational hypertension

Cited by 3 publications

References 38 publications

Glycolysis: A fork in the path of normal and pathological pregnancy

Glycolysis: A fork in the path of normal and pathological pregnancy

Identification of hub glutamine metabolism-associated genes and immune characteristics in pre-eclampsia

Commentary: magnetic resonance spectroscopy and liquid chromatography-mass spectrometry metabolomics study may differentiate pre-eclampsia from gestational hypertension

Contact Info

Product

Resources

About