Magnetic Resonance Spectroscopy Features of the Visual Pathways in Patients with Glaucoma

Aksoy, Direnç Özlem; Akkan, Julide Canan Umurhan; Alkan, Alpay; Aralaşmak, Ayşe; Temur, Hafize Otcu; Yurtsever, İsmail

doi:10.1007/s00062-018-0728-7

Cited by 11 publications

(13 citation statements)

References 25 publications

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“…An overview of the selection process using PRISMA scoping review technique is shown in Figure 1 [6]. From these nine selected studies, seven studies [7][8][9][10][11][12][13] were cross-sectional studies, while two [3,14] were review studies. One [11] of the seven studies was acquired from the result of the Google search engine.…”

Section: Descriptive Analysismentioning

confidence: 99%

“…Another observation was the increasing intricacy in the later studies where investigation of the metabolite concentration involved groups of different glaucoma severities [7] and glaucoma types [10]. It was also interesting to note that the very recent study by Guo et al [8] had recruited participants with early open-angle glaucoma, aimed to associate detected metabolites changes with cortical plasticity.…”

Section: Participants Backgroundmentioning

confidence: 99%

“…It could be seen that most of the studies chose the occipital region [8][9][10]13] as the region of investigation, while the rest reasonably chose vitreous [11,12], laterale geniculate nucleus [10,12] and geniculocalcarine related area [7,13]. Meanwhile, Barbosa-Breda et al [3] published a review paper that discussed the results of other 1 H-MRS studies in vitreous and lateral genicular, as well as their relevance to glaucoma pathogenesis.…”

Section: Anatomy Of Interestmentioning

confidence: 99%

“…The common methods used are the single-voxel spectroscopy (SVS) technique or the multivoxel spectroscopy (MVS) technique. Only one of the included studies [13] used the MVS technique, while the others [7][8][9][10][11][12] used the SVS technique. Meanwhile, the two review studies [3,14] reported the SVS and MVS with little explanation.…”

Section: Spectroscopy Techniquementioning

confidence: 99%

“…Advanced processing software like the linear combination of model (LCModel) and the Java-based magnetic resonance user interface (jMRUI) are widely used to convert raw spectroscopic data into a quantifiable or understandable form for non-expert users [18]. All studies in this review [8][9][10][11][12][13] used embedded scanner MRI manufacturer software except one study by Sidek et al [7] which used an external processing software, LCModel version 6.2. It was shown in Table 1 that there were more metabolites [7] that could be studied by using external software compared to using embedded manufacturer software.…”

Section: Processing Softwarementioning

confidence: 99%

See 4 more Smart Citations

Proton Magnetic Resonance Spectroscopy (1H-MRS) in Studies of Glaucoma: A Scoping Review

Musa¹,

Sidek²,

Hanafiah³

et al. 2021

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Glaucoma is a disease that is chronic in nature and indistinctive at an early stage, leading to late detection. It has become a major public health problem and a leading cause of irreversible blindness worldwide. The proton magnetic resonance spectroscopy (1H-MRS), of late, has been utilised to evaluate metabolites concentration in the brain, especially for detecting neurodegenerative disease. Considering that glaucoma is a neurodegenerative disease, studies on the concentration of metabolites using 1H-MRS in glaucoma patients could be investigated. This scoping review aims to examine the extent, range, and nature of studies on the 1H-MRS technique in glaucoma disease. The literature search was conducted using MEDLINE, CINAHL and SCOPUS, dated from 2000 until 2019. Studies on glaucoma using 1H-MRS were considered. Any processing method used to characterise the metabolite concentration generated by the 1H-MRS protocol has also been considered. Nine full-text studies were yielded after hundreds of literature identification, screening, and eligibility assessment. The included studies sought to determine the feasibility, change, and comparability of metabolite concentrations in glaucoma patients using 1H-MRS with more studies utilising single-voxel spectroscopy (SVS) technique. The chosen anatomy of interest could have been influenced by several criteria, including the association between anatomy and the research query and the volume-sizing capabilities of the 1H-MRS technique. Six (6) metabolites were significantly identified, and quantified, including N-acetyl aspartate, Creatine, Choline, Myo-Inositol, Lactate and Glutamate-Glutamine. This scoping review points out the 1H-MRS application in different types and severity of glaucoma, highlighting the information on the type of patients, the detected metabolites in the anatomy involved, the 1H-MRS technique used and the raw data decipherment processing software. Future studies are needed to validate existing glaucoma studies and to explore the potential of detecting incipient glaucoma.

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Section: Descriptive Analysismentioning

confidence: 99%

Section: Participants Backgroundmentioning

confidence: 99%

Section: Anatomy Of Interestmentioning

confidence: 99%

Section: Spectroscopy Techniquementioning

confidence: 99%

Section: Processing Softwarementioning

confidence: 99%

See 3 more Smart Citations

Proton Magnetic Resonance Spectroscopy (1H-MRS) in Studies of Glaucoma: A Scoping Review

Musa¹,

Sidek²,

Hanafiah³

et al. 2021

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Role of Structural, Metabolic, and Functional MRI in Monitoring Visual System Impairment and Recovery

Sims

Chen

Sun

et al. 2020

Magnetic Resonance Imaging

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T HE VISUAL SYSTEM includes both ocular and neuroanatomy. Recent research has suggested that many visual impairments affect the entire visual system. In addition, their severity cannot be predicted solely via ocular imaging or brain imaging alone. [1][2][3] This suggests the need for a more in-depth understanding of pathogenesis at a systematic level, rather than individual anatomic structures alone. Whereas other imaging modalities are often limited to specific uses in evaluating single aspects of visual impairment in an anatomical structure, magnetic resonance imaging (MRI) can be employed to assess structure, metabolism, and function throughout the visual pathways. Here, we briefly introduce the key anatomical components of the visual system, as well as relevant MRI techniques in examining the pathology and recovery of these tissues. We then detail specific imaging considerations and a selection of recent clinical applications for MRI in each of the major anatomic regions, along with new developments that are being actively explored. Specific MRI parameters for several studies in each anatomic region can be found in Table 1.

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Metabolic alterations in the visual pathway of retinitis pigmentosa rats: A longitudinal multimodal magnetic resonance imaging study with histopathological validation

et al. 2022

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Because retinitis pigmentosa (RP) has been shown to cause degenerative changes in the entire visual pathway, there is an urgent need to perform longitudinal assessments of RP‐induced degeneration and identify imaging protocols to detect this degeneration as early as possible. In this study, we assessed a transgenic rat model of RP by using complementary noninvasive magnetic resonance imaging techniques, namely, proton magnetic resonance spectroscopy (1H‐MRS), to investigate the metabolic changes in RP. Our study demonstrated decreased concentrations and ratios to creatine (Cr) of N‐acetylaspartate (NAA), glutamate (Glu), γ‐aminobutyric acid (GABA), and taurine (Tau), whereas myo‐inositol (Ins) and choline (Cho) were increased in the visual cortex of Royal College of Surgeons (RCS) rats compared with control rats (p < 0.05). Furthermore, with the progression of RP, the concentrations of NAA, Glu, GABA, and Tau, and the ratios of GABA/Cr and Tau/Cr significantly decreased over time, whereas the concentrations of Ins and Cho and the ratio of Ins/Cr significantly increased over time (p < 0.05). In addition, in RCS rats, NAA/Cr decreased significantly from 3 to 4 months postnatal (p < 0.001), and Cho/Cr increased significantly from 4 to 5 months postnatal (p = 0.005). Meanwhile, the 1H‐MRS indicators in 5‐month postnatal RCS rats could be confirmed by immunohistochemical staining. In conclusion, with the progression of RP, the metabolic alterations in the visual cortex indicated progressive reprogramming with the decrease of neurons and axons, accompanied by the proliferation of gliocytes.

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Magnetic Resonance Spectroscopy Features of the Visual Pathways in Patients with Glaucoma

Cited by 11 publications

References 25 publications

Proton Magnetic Resonance Spectroscopy (1H-MRS) in Studies of Glaucoma: A Scoping Review

Proton Magnetic Resonance Spectroscopy (1H-MRS) in Studies of Glaucoma: A Scoping Review

Role of Structural, Metabolic, and Functional MRI in Monitoring Visual System Impairment and Recovery

Metabolic alterations in the visual pathway of retinitis pigmentosa rats: A longitudinal multimodal magnetic resonance imaging study with histopathological validation

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