Magnetic separation of particles and cells in ferrofluid flow through a straight microchannel using two offset magnets

Zeng, Jian; Deng, Yanxiang; Vedantam, Pallavi; Tzeng, Tzuen‐Rong; Xuan, Xiangchun

doi:10.1016/j.jmmm.2013.07.021

Cited by 116 publications

(101 citation statements)

References 48 publications

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“…These capabilities of MMF can be utilized in Lab-On-A-Chip (LOC) devices, e.g., in micro-fluid valves or micropumps, 2,3 as well as the separation and extraction of biological particles. 4,5 Other applications include separation of diamagnetic particles, 6,7 rotating seals, 8 loudspeakers, 9 and microlens arrays. 10,11 Usually, permanent magnets [12][13][14] or electromagnets 15,16 are placed adjacent to LOC devices to produce a magnetic field gradient.…”

Section: Introductionmentioning

confidence: 99%

Spreading of a ferrofluid core in three-stream micromixer channels

et al. 2015

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Spreading of a water based ferrofluid core, cladded by a diamagnetic fluid, in threestream micromixer channels was studied. This spreading, induced by an external magnetic field, is known as magnetofluidic spreading (MFS). MFS is useful for various novel applications where control of fluid-fluid interface is desired, such as micromixers or micro-chemical reactors. However, fundamental aspects of MFS are still unclear, and a model without correction factors is lacking. Hence, in this work, both experimental and numerical analyses were undertaken to study MFS. We show that MFS increased for higher applied magnetic fields, slower flow speed of both fluids, smaller flow rate of ferrofluid relative to cladding, and higher initial magnetic particle concentration. Spreading, mainly due to connective diffusion, was observed mostly near the channel walls. Our multi-physics model, which combines magnetic and fluidic analyses, showed, for the first time, excellent agreement between theory and experiment. These results can be useful for lab-on-a-chip devices. C 2015 AIP Publishing LLC. [http://dx.

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Section: Introductionmentioning

confidence: 99%

Spreading of a ferrofluid core in three-stream micromixer channels

et al. 2015

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“…Also neglected are the dipole-dipole interactions among the same type or different types of particles in a magnetic field. Such a treatment of particle-fluid and particle-particle interactions has been demonstrated reasonable in previous theoretical studies from the groups of Mao et al, 28,32,37,40,42 Nguyen et al, 41 and Xuan et al 30,31,33,36,39 as long as the particle and ferrofluid concentrations are both low. These conditions are fulfilled in the current work because of the use of a dilute particle suspension in a diluted ferrofluid.…”

Section: Simulationmentioning

confidence: 53%

“…[28][29][30][31][32][33][36][37][38][39][40][41]47 As such, the steady-state flow field in the T-shaped microchannel, u, is governed by the conventional continuity and Navier-Stokes equations…”

Section: Flow Field and Concentration Field Of The Ferrofluidmentioning

confidence: 99%

“…23,24 This positive magnetophoretic motion has been widely utilized to concentrate and isolate magnetically-tagged target cells (e.g., circulating tumor cells) from a heterogeneous mixture. [25][26][27] Diamagnetic particles must be re-suspended in magnetic media like ferrofluids [28][29][30][31][32][33] and paramagnetic solutions, 34,35 so that they experience negative magnetophoresis and are repelled away from the magnetic source. [36][37][38][39][40][41][42] While magnetic particle trapping has been demonstrated with single magnets placed on one side of the particle flowing microchannel, 23-27 diamagnetic particle trapping can only take place stably with one or multiple pair(s) of magnets arranged on both sides of the channel.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous diamagnetic and magnetic particle trapping in ferrofluid microflows via a single permanent magnet

Zhou

Kumar

et al. 2015

Biomicrofluidics

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Trapping and preconcentrating particles and cells for enhanced detection and analysis are often essential in many chemical and biological applications. Existing methods for diamagnetic particle trapping require the placement of one or multiple pairs of magnets nearby the particle flowing channel. The strong attractive or repulsive force between the magnets makes it difficult to align and place them close enough to the channel, which not only complicates the device fabrication but also restricts the particle trapping performance. This work demonstrates for the first time the use of a single permanent magnet to simultaneously trap diamagnetic and magnetic particles in ferrofluid flows through a T-shaped microchannel. The two types of particles are preconcentrated to distinct locations of the T-junction due to the induced negative and positive magnetophoretic motions, respectively. Moreover, they can be sequentially released from their respective trapping spots by simply increasing the ferrofluid flow rate. In addition, a three-dimensional numerical model is developed, which predicts with a reasonable agreement the trajectories of diamagnetic and magnetic particles as well as the buildup of ferrofluid nanoparticles.

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“…The diamagnetic separation principle can also be applied for separation by size [102]. The yeast cells have been successfully separated from each other in EMG408 ferrofluid [142] with a permanent magnet. Alternating magnetic field can also be applied to separate RBCs and RBCs with sickle cell anemia [65].…”

Section: Applicationmentioning

confidence: 99%

Microfluidic bio-particle manipulation for biotechnology

Çetin

Özer

Solmaz

2014

Biochemical Engineering Journal

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a b s t r a c tMicrofluidics and lab-on-a-chip technology offers unique advantages for the next generation devices for diagnostic therapeutic applications. For chemical, biological and biomedical analysis in microfluidic systems, there are some fundamental operations such as separation, focusing, filtering, concentration, trapping, detection, sorting, counting, washing, lysis of bio-particles, and PCR-like reactions. The combination of these operations led to the complete analysis systems for specific applications. Manipulation of the bio-particles is the key ingredient for these applications. Therefore, microfluidic bio-particle manipulation has attracted a significant attention from the academic community. Considering the size of the bio-particles and the throughput of the practical applications, manipulation of the bio-particles is a challenging problem. Different techniques are available for the manipulation of bio-particles in microfluidic systems. In this review, some of the techniques for the manipulation of bio-particles; namely hydrodynamic based, electrokinetic-based, acoustic-based, magnetic-based and optical-based methods have been discussed. The comparison of different techniques and the recent applications regarding the microfluidic bio-particle manipulation for different biotechnology applications are presented. Finally, challenges and the future research directions for microfluidic bio-particle manipulation are addressed.

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Magnetic separation of particles and cells in ferrofluid flow through a straight microchannel using two offset magnets

Cited by 116 publications

References 48 publications

Spreading of a ferrofluid core in three-stream micromixer channels

Spreading of a ferrofluid core in three-stream micromixer channels

Simultaneous diamagnetic and magnetic particle trapping in ferrofluid microflows via a single permanent magnet

Microfluidic bio-particle manipulation for biotechnology

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