Magnetic silica nanocomposites for magnetic hyperthermia applications

Ansari, Legha; Malaekeh‐Nikouei, Bizhan

doi:10.1080/02656736.2016.1243736

Cited by 34 publications

(19 citation statements)

References 100 publications

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“…However, some studies demonstrated that the heating efficiency of the coated silica NPs was generally higher than that of bare magnetic core, Kaman et al speculated that it was partially related to the different hydrodynamic behaviour, which represented that the silica-coated NPs possessed large hydrodynamic diameter and were strongly hydrated [36]. Although the optimal thickness of the coating is still an open question, Ansari [24] pointed out that the optimal amount of silica should be the minimum necessary to keep the core-shell NPs stable in water and also not to reduce the heat emission capability.…”

Section: Biocompatibility Of Zn 05 Fe 25 O 4 /Siomentioning

confidence: 99%

The cell uptake properties and hyperthermia performance of Zn _0.5 Fe _2.5 O ₄ /SiO ₂ nanoparticles as magnetic hyperthermia agents

Wang¹,

Liu²,

Liu³

et al. 2020

R. Soc. open sci.

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Zn 0.5 Fe 2.5 O 4 nanoparticles (NPs) of 22 nm are synthesized by a one-pot approach and coated with silica for magnetic hyperthermia agents. The NPs exhibit superparamagnetic characteristics, high-specific absorption rate (SAR) (1083 wg −1 , f = 430 kHz, H = 27 kAm −1 ), large saturation magnetization ( M s = 85 emu g −1 ), excellent colloidal stability and low cytotoxicity. The cell uptake properties have been investigated by Prussian blue staining, transmission electron microscopy and the inductively coupled plasma-mass spectrometer, which resulted in time-dependent and concentration-dependent internalization. The internalization appeared between 0.5 and 2 h, the NPs were mainly located in the lysosomes and kept in good dispersion after incubation with human osteosarcoma MG-63 cells. Then, the relationship between cell uptake and magnetic hyperthermia performance was studied. Our results show that the hyperthermia efficiency was related to the amount of internalized NPs in the tumour cells, which was dependent on the concentration and incubation time. Interestingly, the NPs could still induce tumour cells to apoptosis/necrosis when extracellular NPs were rinsed, but the cell kill efficiency was lower than that of any rinse group, which indicated that local temperature rise was the main factor that induced tumour cells to death. Our findings suggest that this high SAR and biocompatible silica-coated Zn 0.5 Fe 2. O 4 NPs could serve as new agents for magnetic hyperthermia.

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Section: Biocompatibility Of Zn 05 Fe 25 O 4 /Siomentioning

confidence: 99%

The cell uptake properties and hyperthermia performance of Zn _0.5 Fe _2.5 O ₄ /SiO ₂ nanoparticles as magnetic hyperthermia agents

Wang¹,

Liu²,

Liu³

et al. 2020

R. Soc. open sci.

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“…These core-shell type MSNs can be promising theranostic nanocarriers with high loading capability, cell targeting specificity, and bio-imaging agents, as well as by adding stimuli-responsive drug release and hyperthermia treatment. [16][17][18][19][20] Graphene oxide (GO) possesses advantageous biocompatibility, large specific surface area, and π-conjugated nanostructures which can confer excellent water solubility, physiological stability, and capacity for drug delivery. 21,22 Likewise, polydopamine (PDA) possess good biocompatibility, unique chemical structure, and photothermal heating effects, which can be rapidly integrated into the construction of tumor-targeted drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

<p>Multimodal Mesoporous Silica Nanocarriers for Dual Stimuli-Responsive Drug Release and Excellent Photothermal Ablation of Cancer Cells</p>

Tran

Giau

Shim

et al. 2020

IJN

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Background: Core-shell types of mesoporous silica nanoparticles (MSNs) with multimodal functionalities were developed for bio-imaging, controlled drug release associated with external pH, and near-infrared radiation (NIR) stimuli, and targeted and effective chemo-photothermal therapeutics. Materials and Methods: We synthesized and developed a core-shell type of mesoporous silica nanocarriers for fluorescent imaging, stimuli-responsive drug release, magnetic separation, antibody targeting, and chemo-photothermal therapeutics. Also, the biocompatibility, cellular uptake, cytotoxicity, and photothermal therapy on these FS3-based nanocarriers were systematically investigated. Results: Magnetic mesoporous silica nanoparticles was prepared by coating a Fe 3 O 4 core with a mesoporous silica shell, followed by grafting with fluorescent conjugates, so-called FS3. The resulting FM3 was preloaded with therapeutic cisplatin and coated with polydopamine layer, socalled FS3P/C. Eventually, graphene oxide-wrapped FS3P/C (FS3P-G/C) exhibited high sensitivity in the dual stimuli (pH, NIR)-responsive controlled release behavior. On the other hand, Au NPs-coated FS3P/C (FS3P-A/C) exhibited more stable release behavior, irrespective of pH changes, and exhibited much more enhanced release rate under the same NIR irradiation. Notably, FS3P-A/C showed strong NIR absorption, enabling photothermal destruction of HeLa cells by its chemo-photothermal therapeutic effects under NIR irradiation (808 nm, 1.5 W/cm 2). The selective uptake of FS3-based nanocarriers was confirmed in cancer cell lines including HeLa (American Type Culture Collection-ATCC) and SHSY5Y (ATCC 2266) by the images obtained from confocal laser scanning microscopy, flow cytometry, and transmission electron microscopy instruments. Cisplatin-free FS3-based nanocarriers revealed good cellular uptake and low cytotoxicity against cancerous HeLa and SH-SY5Y cells, but showed no obvious toxicity to normal HEK293 (ATCC 1573) cell. Conclusion: Along with the facile synthesis of FS3-based nanocarriers, the integration of all these strategies into one single unit will be a prospective candidate for biomedical applications, especially in chemo-photothermal therapeutics, targeted delivery, and stimuliresponsive controlled drug release against multiple cancer cell types.

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“…Superparamagnetic iron oxide nanoparticles (SPI-ONs) are inorganic nanoparticles which exhibit intrinsic magnetic properties when exposed to external magnetic field. SPIONs have been explored and utilized in various biomedical applications such as bioimaging 1 , biological separation 2,3 , drug delivery and cancer therapy [4][5][6] . Several methods have been developed for SPIONs synthesis in aqueous solvent 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Preparation of superparamagnetic iron oxide nanoparticles and investigation of their interaction with cells

Mekseriwattana¹,

Srisuk²,

Tantiapibalkun³

et al. 2019

ScienceAsia

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Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely studied in biomedical applications such as bioimaging through magnetic resonance imaging and drug delivery. The successful uses of SPIONs depend on nanoparticles stability in biological environment and their interactions with cells. Hence these two factors are crucial for improvement of nanoparticle design in these applications. In this work, SPIONs were synthesized with silica (S-SPIONs) and amine (A-SPIONs) surface modifications providing hydroxyl and amine functionalities, respectively. The colloidal stabilities of SPIONs were evaluated as hydrodynamic size in different biological relevance media. The results showed that bare SPIONs were unstable and highly aggregated when exposed to cell culture media. Coating with silica and amine could effectively stabilized the nanoparticles as evidenced by reduction of hydrodynamic diameters. In addition to surface modification, supplementation of serum proteins to cell culture media also reduced the aggregations. Furthermore, both S-SPIONs and A-SPIONs showed no cytotoxicity effect on human breast cancer cells (MCF-7) with cell viability remained over 80%. Hence this study showed the role of surface modification of bare SPIONs with silica and amine functionalization and serum supplement to stabilize nanoparticle stability in biological environment. These two surface coating SPIONs were not only non-toxic to the cells, but also have surface functionalities that could be further conjugated with desired biomolecules for more specific targeting especially in cancer targeting for diagnosis or therapeutic applications.

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Magnetic silica nanocomposites for magnetic hyperthermia applications

Cited by 34 publications

References 100 publications

The cell uptake properties and hyperthermia performance of Zn _0.5 Fe _2.5 O ₄ /SiO ₂ nanoparticles as magnetic hyperthermia agents

The cell uptake properties and hyperthermia performance of Zn _0.5 Fe _2.5 O ₄ /SiO ₂ nanoparticles as magnetic hyperthermia agents

<p>Multimodal Mesoporous Silica Nanocarriers for Dual Stimuli-Responsive Drug Release and Excellent Photothermal Ablation of Cancer Cells</p>

Preparation of superparamagnetic iron oxide nanoparticles and investigation of their interaction with cells

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Magnetic silica nanocomposites for magnetic hyperthermia applications

Cited by 34 publications

References 100 publications

The cell uptake properties and hyperthermia performance of Zn 0.5 Fe 2.5 O 4 /SiO 2 nanoparticles as magnetic hyperthermia agents

The cell uptake properties and hyperthermia performance of Zn 0.5 Fe 2.5 O 4 /SiO 2 nanoparticles as magnetic hyperthermia agents

<p>Multimodal Mesoporous Silica Nanocarriers for Dual Stimuli-Responsive Drug Release and Excellent Photothermal Ablation of Cancer Cells</p>

Preparation of superparamagnetic iron oxide nanoparticles and investigation of their interaction with cells

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The cell uptake properties and hyperthermia performance of Zn _0.5 Fe _2.5 O ₄ /SiO ₂ nanoparticles as magnetic hyperthermia agents

The cell uptake properties and hyperthermia performance of Zn _0.5 Fe _2.5 O ₄ /SiO ₂ nanoparticles as magnetic hyperthermia agents