Magnetic Solid-Phase Extraction Based on Magnetite-Multiwalled Carbon Nanotubes of Non-Steroidal Anti-Inflammatories from Water Followed by LC–ESI–MS/MS

Abstract

An analytical method based on liquid chromatography–electrospray ionization–tandem mass spectrometry detection (LC–ESI–MS/MS) has been developed for the determination of pharmaceutical compounds in water samples. Five non-steroidal anti-inflammatory drugs (NSAIDs) namely Naproxen, Ketoprofen, Piroxicam, Diflunisal and Celecoxib were investigated. Magnetic solid phase extraction (MSPE) was used for sample pre concentration of water samples and magnetic carbon nanotubes (Fe3O4-MWCNTs) were considered as solid phase extraction sorbent. Important parameters influencing the extraction efficiency such as nature and volume of eluent, sample pH and adsorbent mass were optimized. The developed MSPE method involved 75 mg of Fe3O4-MWCNTs sorbent, 5 mL of water sample at pH = 4 and 5 mL of 10% ammonia in methanol in the elution step. Under the optimized extraction conditions, linearity, detection and quantification limits and reproducibility were evaluated. The proposed method was successfully applied to the analysis of NSAIDs in surface waters, and mean recoveries of all the NSAIDs were above 90% with relative standard deviations < 17%. The detection and quantification limits were comprised between 0.05–3.6 ng.mL−1 and 0.2–11.9 ng.mL−1, respectively.

Green and efficient magnetic micro-solid phase extraction utilizing tea waste impregnated with magnetic nanoparticles for the analysis of ibuprofen in water samples by using UV-vis spectrophotometry

“…MNP-TW provides a large surface area, which facilitates strong adsorption for their p-p electrostatic interactions with the aromatic rings of the targets, which explains the adsorption capacity variation and thus the limited number of active sites. 37 However, the extraction efficiency decreases aer 25 mg due to particle aggregation that happens when a high mass of adsorbent is present, which reduces the surface area of MNP-TW exposed to IBP for the adsorption to occur. 32,38 Effect of pH.…”

High-Throughput Capillary Liquid Chromatography Using a Droplet Injection and Application to Reaction Screening

“…Further, they hinder interface to mass spectrometry (MS) detection since optimal flow rates for liquid chromatography (LC)-electrospray ionization (ESI)-MS experiments are typically 10–300 μL/min. , Therefore, faster injection schemes and smaller scale columns would make high-throughput LC more feasible and useful. The potential for higher-throughput injection has been demonstrated with a commercial HPLC-style injector that has been interfaced to solid-phase extraction-ESI-MS for analysis rates up to 10 s per sample. − Numerous applications have been demonstrated with this system. − While clearly powerful and filling a need, it does not provide chromatographic separation, relies on high flow rates, and consumes 10 μL of sample per assay. Limited attention has been devoted to the potential utilization of droplet microfluidics for injections in liquid chromatography .…”

The potential of lignocellulosic biomass for magnetic solid phase extraction of naproxen from saliva samples

“…16 MSPE, based on the use of a magnetic sorbent, is a better alternative approach that can facilitate the separation of a powder material with an external magnet, eliminating ltration and centrifugation steps and thus providing the advantage of easy operation. 7,[17][18][19][20][21][22][23] In the eld of magnetic solid phase extraction (MSPE), magnetic biochar has emerged as a valuable tool. This innovative material combines the adsorption capabilities of biochar with the magnetic properties that facilitate separation and regeneration processes.…”