Magnetic solid phase extraction followed by in-situ derivatization with core-shell structured titanium dioxide coated ferriferrous oxide microspheres for determination of alendronate in plasma

She, Xiaojian; Li, Jiajia; Zhu, Jinglin; Huang, Taomin; Li, Yan

doi:10.1016/j.chroma.2020.461809

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…Besides, the magnetic contents can be easily controlled up to more than 30% [18]. To avoid the magnetic contents being oxidized as well as contact with the detection environment directly, inorganic materials like SiO 2 and TiO 2 are usually used as protective layers on the surface of polymer@Fe 3 O 4 microspheres to form sandwich structures [19,20].…”

Section: Introductionmentioning

confidence: 99%

Strategies Towards Submicron Size and High-Performance Magnetic PGMA@Fe3O4@SiO2–COOH Microspheres with Biological Application

Xia,

Wang,

Awasthi

et al. 2024

J Inorg Organomet Polym

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The separation of target substances is a signi cant biological detection procedure, where magnetic microspheres can act as high-performance separation materials. However, challenges are still kept to ful ll all the requirements. In this study, a type of submicron magnetic poly (glycidyl methacrylate) (PGMA) microsphere was prepared with an in situ coprecipitation method, an electrostatic self-assembly method, and a silica surface coating method. Firstly, the PGMA microspheres were synthesized by a soap-free emulsion polymerization method, and surface charge density determined the coagulation process, further in uencing the size and monodispersity. Then we found the Superparamagnetism properties of magnetic microspheres could be well controlled by the capping agent sodium citrate (Na 3 Cit), and the superparamagnetic critical size was 10.9 nm. Also, the saturation magnetization was well controlled by the Fe 2+ and Fe 3+ concentration, which was correlated with the nucleation rate of Fe 3 O 4 crystal. Furthermore, we proved that the electrostatic self-assembly was guided by pH, and it was proposed to tightly couple the PGMA-NH 2 microspheres with positive charges and Fe 3 O 4 nanoparticles with negative charges. Finally, the PGMA@Fe 3 O 4 microspheres were coated with SiO 2 , surface modi ed by carboxyl groups for application. The PGMA@Fe 3 O 4 and carboxyl-modi ed microspheres exhibited saturated magnetization values of 23.73 and 17.73 emu/g, respectively. These microspheres have been effectively utilized for the extraction of DNA from various sources such as Salmonella typhi, monkeypox virus, and clinical swab samples, suggesting the potential of these microspheres for nucleic acid separation in the biomedical domain.

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Section: Introductionmentioning

confidence: 99%

Strategies Towards Submicron Size and High-Performance Magnetic PGMA@Fe3O4@SiO2–COOH Microspheres with Biological Application

Xia,

Wang,

Awasthi

et al. 2024

J Inorg Organomet Polym

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“…Magnetic solid-phase extraction (MSPE), utilizes magnetic nanoparticles as adsorbents to recover analytes from large-volume samples under external magnetic field . Compared to other industrially relevant separation methods including LLE and SPE, the MSPE technique bypasses use of organic solvents and offers advantage in separation efficiency. , However, the selectivity of analyte retention dictated by hydrophobic interactions is often too low to satisfy the requirement of trace analysis in complex samples, especially when interfering substances arising from co-extraction and matrix effect are at high level. Therefore, a remarkable interest has been witnessed in the development of selective MSPE sorbents to afford clean-up, isolation and concentration of target compounds in a single step.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Liposomes Infused with GPCR-Expressing Cell Membrane for Targeted Extraction Using Minimum Organic Solvent: An Investigative Study of Trace THC in Sewage

et al. 2023

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Trace analysis of lipophilic substances in complex environmental, food, or biological matrices has proven to be a challenge, on account of their high susceptibility to adsorption by particulate matter and liquid–solid interfaces. For this purpose, liquid–liquid extraction (LLE) is often employed as the separation method, which uses water-immiscible organic solvents. As an alternative, magnetic solid-phase extraction (MSPE) allows for adsorption, separation, and recovery of analytes from large volumes of aqueous samples with minimum usage of organic solvents. However, the poor selectivity hampers its performance in various scenarios, especially in sewage samples where complicated and unpredictable interference exists, resulting in block of the active adsorption sites of the sorbent. To this end, we propose receptor-affinity MSPE employing magnetic liposomes decorated with cell membranes expressing G-protein-coupled receptor as the sorbents. Application of the novel sorbent CM@Lip@Fe infused with CB1 cannabinoid receptors was demonstrated for the targeted extraction and enrichment of tetrahydrocannabinol from sewage matrix. Thanks to the high affinity and molecular selectivity of the ligand-receptor interactions, a limit of quantitation of 5.17 ng/L was achieved coupled with HPLC-MS/MS in unfiltered raw sewage, featuring minimum usage of organic solvents, fivefold enhanced sensitivity, low sorbent dosage (75 mg/L of sewage), and high efficiency as major advantages over conventional LLE. This work establishes a framework for efficient separation of specific molecules from complex media, thus promising to extend and refine standard LLE as the clean-up procedure for trace analysis.

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“…Therefore, it is necessary to develop pharmaceutical analysis methods to remove the interference of impurities and improve the sensitivity of detection. Until now, various sample preparation methods have been utilized for pharmaceutical analysis, including solidphase extraction (SPE) [5][6][7], magnetic SPE (MSPE) [8,9], solid-phase microextraction (SPME) [10][11][12], and others. Regardless of the chosen sample preparation methods, the adsorbents are the core component of the extraction process [13], because the adsorbents directly influence the selectivity and adsorption capacity of targets in samples.…”

Section: Introductionmentioning

confidence: 99%

“…Porous organic materials including metal-organic frameworks (MOFs) [16][17][18][19], covalent organic frameworks (COFs) [20][21][22][23], and porous organic polymers (POPs) [9,24] have been fabricated and utilized for sample preparation, yielding satisfying results. These porous materials possess a larger surface area, adjustable pore size, and stable chemical properties.…”

Section: Introductionmentioning

confidence: 99%

Advanced porous organic materials for sample preparation in pharmaceutical analysis

Zhang

Huang

et al. 2023

J of Separation Science

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The development of novel sample preparation media plays a crucial role in pharmaceutical analysis. To facilitate the extraction and enrichment of pharmaceutical molecules in complex samples, various functionalized materials have been developed and prepared as adsorbents. Recently, some functionalized porous organic materials have become adsorbents for pharmaceutical analysis due to their unique properties of adsorption and recognition. These advanced porous organic materials, combined with consequent analytical techniques, have been successfully used for pharmaceutical analysis in complex samples such as environmental and biological samples. This review encapsulates the progress of advanced porous materials for pharmaceutical analysis including pesticides, antibiotics, chiral drugs, and other compounds in the past decade. In addition, we also address the limitations and future trends of these porous organic materials in pharmaceutical analysis.

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Magnetic solid phase extraction followed by in-situ derivatization with core-shell structured titanium dioxide coated ferriferrous oxide microspheres for determination of alendronate in plasma

Cited by 8 publications

References 40 publications

Strategies Towards Submicron Size and High-Performance Magnetic PGMA@Fe3O4@SiO2–COOH Microspheres with Biological Application

Strategies Towards Submicron Size and High-Performance Magnetic PGMA@Fe3O4@SiO2–COOH Microspheres with Biological Application

Magnetic Liposomes Infused with GPCR-Expressing Cell Membrane for Targeted Extraction Using Minimum Organic Solvent: An Investigative Study of Trace THC in Sewage

Advanced porous organic materials for sample preparation in pharmaceutical analysis

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