Magnetic switchable alginate beads

Degen, Patrick; Leick, Sabine; Siedenbiedel, Felix; Rehage, Heinz

doi:10.1007/s00396-011-2524-7

Cited by 17 publications

(9 citation statements)

References 48 publications

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“…Alginate was discovered as a structural component of brown marine algae [7]. Until now, alginate has been processed extensively as capsules, beads, and fibers for various application fields, especially in drug delivery [8]. It is suitable for encapsulating targeted drugs because of favorable properties such as water solubility [9], nontoxicity [10], and biodegradability [11].…”

Section: Introductionmentioning

confidence: 99%

The Size Stability of Alginate Beads by Different Ionic Crosslinkers

Huang

Lin

2017

Advances in Materials Science and Engineering

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Few studies have discussed the stability of gelled alginate bead size. Therefore, the present study investigated the dynamic shrinkage of gelled alginate beads affected by two common ionic crosslinkers at different concentrations and temperatures. The results indicate that the gelled alginate beads gradually shrank with longer gelling times. The beads incubated in a Ca 2+ solution shrank more dramatically than those incubated in a Ba 2+ solution. Those incubated at room temperature exhibited greater shrinkage than those incubated at a low temperature. A 25% size reduction occurred in the 1% Ca 2+ solution at room temperature after 300 minutes of gelling time. The alginate beads gelled took at least 120 minutes to become stable after the ionic gelation process.

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Section: Introductionmentioning

confidence: 99%

The Size Stability of Alginate Beads by Different Ionic Crosslinkers

Huang

Lin

2017

Advances in Materials Science and Engineering

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“…Divalent cations such as Ca 2+ and Ba 2+ bind to the G-blocks of alginate in a highly cooperative manner, such that a gel is formed [8,9]. Commonly used in a wide variety of fields, alginate is so far mainly processed into capsules, beads, and fibres [10] and has been frequently used for encapsulation of biologically active agents [11].…”

Section: Introductionmentioning

confidence: 99%

Effects of pH on the Shape of Alginate Particles and Its Release Behavior

Chuang

Huang

et al. 2017

International Journal of Polymer Science

124

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A vast majority of alginate particles exist as spheres in most practical uses, and both the particle shape and size are the key factors dominating the applications and performance of alginate gels. Therefore, it becomes an issue of great interest to investigate the aspheric alginate particles. As the first step, various shaped alginate particles were formed due to various pH values in gelation solutions. It was experimentally demonstrated that a low pH brought about an oblate shape, and particularly lower concentrations of both alginate and divalent cations resulted in a flattened oblate shape. Ba2+acting as a cross-linker had a less impact on the particle shape than Ca2+due to a higher affinity in alginate intermolecular cross-linking. With a larger surface area, an oblate particle offered a higher release rate than a spheric one.

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“…Gambar 5 merupakan hasil uji swelling terhadap ke empat membran komposit, dari data tersebut nilai uji swelling terbesar terdapat pada membran komposit PA-1 (kontrol), dengan persentase derajat swelling 2161,17%. Besarnya persentase ini, disebabkan kerena membran hanya tersusun dari natrium alginat yang memiliki gugus anionik (hidroksil dan karboksil) sehingga berdampak pada kurang rapatnya ikatan molekul antar rantai polimer dan menimbulkan ruang yang lebih besar untuk menyerap cairan yang berakibat meningkatnya daya serap membran (Degen et al, 2012).…”

Section: Hasil Dan Pembahasanunclassified

Membran Alginat Padina sp. - Polietilen Glikol (AP-PEG): Preparasi, Karakterisasi dan Aplikasinya sebagai Enkapsulan

et al. 2021

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Pengembangan penelitian tentang material berbasiskan sumber daya alam lokal dan dapat diperbaharui terus dikembangkan akhir-akhir ini. Hal tersebut didasari adanya kebutuhan material baru dengan karakteristik yang lebih menguntungkan dan dapat digunakan pada aplikasi yang spesifik. Penelitian ini bertujuan untuk mempelajari preparasi membran alginat-polietilen glikol (AP-PEG) dan aplikasinya sebagai enkapsulan. Alginat yang digunakan adalah hasil ekstraksi dari rumput laut cokelat Padina sp. Dengan metode maserasi jalur asam alginat. Preparasi membrane alginat Padina sp.-polietilen glikol (AP-PEG) dilakukan dengan perbandingan PEG-AP = 1:5; 1:10; 1:15; 0:1 (b/b). Analisis gugus fungsi terhadap seluruh membran yang dihasilkan, menunjukkan bahwa membran AP-PEG yang dihasilkan diprediksi sebagai hasil blending secara fisika karena tidak ada gugus fungsi baru yang terbentuk. Membran dengan perbandingan berat PEG-AP=1:15 memiliki karakteristik terbaik dengan persentase swelling sebesar 1465,5%, stress sebesar 14,588 MPa, strain 0,07 dan Modulus Young sebesar 193,13 MPa. Hasil analisis morfologi menunjukkan bahwa banyak rongga ditemukan pada membrane tersebut. Hasil uji disolusi terhadap membrane tersebut menunjukkan bahwa, pada pH 1,2 membran tersebut dapat melepaskan vitamin C sebesar 78,12% selama 60 menit dan tidak mengalami cracking. Di sisi lain, pada pH 7,2 membran tersebut dapat melepaskan vitamin C sebesar 83,54% dan cracking terjadi dalam waktu 12 menit. Hasil penelitian ini menunjukkan bahwa komposit AP-PEG dapat dibuat dari rumput laut coklat dan memiliki kemampuan sebagai enkapsulan. Alginate Padina sp.-Polyethylene Glycol (AP-PEG) Membranes: Preparation, Characterization and Their Application as Encapsulant. The development of research on materials based on local and renewable natural resources has been continuously being developed recently. This is based on the need for new materials with more favorable characteristics and can be used in specific applications. This research aims to study the synthesis of alginate-polyethylene glycol (AP-PEG) membranes and their application as an encapsulant. The alginate was extracted from the brown seaweed Padina sp. by maceration method using alginic acid pathway. Alginate Padina sp.-polyethylene glycol (AP-PEG) alginate membrane was prepared with a ratio of PEG:AP = 1: 5, 1:10, 1:15 and 0:1 (w/w). The functional group analysis showed that the resulting AP-PEG membranes were predicted as a result of physical blending due to no new functional groups are formed. The membrane with a weight ratio of PEG:AP = 1:15 had the best characteristics, with a percentage of swelling of 1465.5%, stress of 14.588 MPa, 0.07 strain, and Young Modulus of 193.13 MPa. Morphological analysis showed that the membrane obtained had many cavities. The dissolution test showed that the AP-PEG membrane was able to release vitamin C of 78.12% for 60 minutes at pH 1.2 and no cracking was observed, while at pH 7.2 the membrane was able to distribute vitamin C by 83.54% and cracking occurs within 12 minutes. The results of this study indicate that AP-PEG composites can be made from brown seaweed and have good encapsulant capabilities.

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Magnetic switchable alginate beads

Cited by 17 publications

References 48 publications

The Size Stability of Alginate Beads by Different Ionic Crosslinkers

The Size Stability of Alginate Beads by Different Ionic Crosslinkers

Effects of pH on the Shape of Alginate Particles and Its Release Behavior

Membran Alginat Padina sp. - Polietilen Glikol (AP-PEG): Preparasi, Karakterisasi dan Aplikasinya sebagai Enkapsulan

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