Magnetic targeting of smooth muscle cells in vitro using a magnetic bacterial cellulose to improve cell retention in tissue-engineering vascular grafts

Arias, Sandra L.; Shetty, Akshath R.; Devorkin, Joshua; Allain, Jean Paul

doi:10.1016/j.actbio.2018.07.013

Cited by 62 publications

(54 citation statements)

References 32 publications

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“…Aiming at quickening the re‐endothelization of a severed vascular tissue, BC hydrogels with magnetic properties have been developed and characterized, since this kind of materials can recruit tissue‐regenerating cells . The magnetic BC hydrogel was prepared by a simple method consisting of the immersion of the BC hydrogel in a solution containing iron II and III salts, following in situ synthesis of magnetic iron nanoparticles.…”

Section: Applicationsmentioning

confidence: 99%

“…Even though these type of nanoparticles are used in magnetic resonance imaging, in higher concentrations they disrupt the mitochondrial respiratory chain and start to generate radical oxygen species (ROS) . In order to evaluate the cell recruitment/cytotoxicity ratio of the magnetic BC hydrogels, a gradient concentration of magnetic Fe nanoparticles were prepared within the BC hydrogels, and it was observed in in vitro studies that for concentrations as low as 25 mM there was a substantial cell recruitment, while maintaining a cell viability similar to the one of unmodified BC. Furthermore, for higher concentrations of these nanoparticles, cytotoxicity was observable, where for concentrations of nanoparticles of 100 mM, the cell viability was very low.…”

Section: Applicationsmentioning

confidence: 99%

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Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

128

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Bacterial cellulose (BC) is a nanocellulose form produced by some nonpathogenic bacteria. BC presents unique physical, chemical, and biological properties that make it a very versatile material and has found application in several fields, namely in food industry, cosmetics, and biomedicine. This review overviews the latest state‐of‐the‐art usage of BC on three important areas of the biomedical field, namely delivery systems, wound dressing and healing materials, and tissue engineering for regenerative medicine. BC will be reviewed as a promising biopolymer for the design and development of innovative materials for the mentioned applications. Overall, BC is shown to be an effective and versatile carrier for delivery systems, a safe and multicustomizable patch or graft for wound dressing and healing applications, and a material that can be further tuned to better adjust for each tissue engineering application, by using different methods.

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Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

128

View full text Add to dashboard Cite

show abstract

“…In the process of the in situ precipitation, the network of the hydrogels acts as a chemically reactive substance, within which the iron ions from inorganic salts in hydrogels react with alkali solutions (e.g., NH 3 •H 2 O, NaOH; Arias et al, 2018;Liu et al, 2019) to prepare the magnetic particles. In detail, the hydrogels are firstly prepared through polymerization, temperature change, or a crosslinking reaction.…”

Section: In Situ Precipitation Methodsmentioning

confidence: 99%

Recent Advances on Magnetic Sensitive Hydrogels in Tissue Engineering

et al. 2020

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Tissue engineering is a promising strategy for the repair and regeneration of damaged tissues or organs. Biomaterials are one of the most important components in tissue engineering. Recently, magnetic hydrogels, which are fabricated using iron oxide-based particles and different types of hydrogel matrices, are becoming more and more attractive in biomedical applications by taking advantage of their biocompatibility, controlled architectures, and smart response to magnetic field remotely. In this literature review, the aim is to summarize the current development of magnetically sensitive smart hydrogels in tissue engineering, which is of great importance but has not yet been comprehensively viewed.

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“…Recent years, an approach of superparamagnetic scaffolds in combination with static magnetic fields has attracted increasing interests for research into bone tissue engineering [35][36] applications, and this approach has been also applied in 3D 37 printing technology. Increasing studies have indicated that superparamagnetic nanoparticles embedded in scaffolds can still be magnetized under magnetic fields, which allow the scaffolds show 9,38 the superparamagnetic performance that has been demonstrated 5,6,8,10,31 promotion of osteogenesis in vitro and in vivo. However, whether the superparamagnetic property is associated with polymer chemistry and physical morphology is still unkonwn.…”

Section: Research Papermentioning

confidence: 99%

Modulatory Effects of the Composition and Structure on the Osteogenic Enhancement for Superparamagnetic Scaffolds

Hao¹,

Shen²,

Wu³

et al. 2018

Eng. Sci.

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Increasing evidence shows that superparamagnetic scaffolds can enhance the osteogenesis under magnetic fields. The aim of this work is to compare the magnetization and the osteogenic enhancement of superparamagnetic scaffolds composed of different compositions with different microstructures. Herein 9 kinds of superparamagnetic scaffolds of PLA, polyurethane and gelatin were fabricated by incorporating iron oxide nanoparticles in polymeric matrices, and using the process of electrospinning, salt-leaching, and solution casting to obtain microstructure of nanofibrous, porous and smooth respectively, while hydroxyapatite nanoparticles were incorporated in all the scaffolds with the same percentage. It was showed that the magnetization behavior of the scaffolds was associated with the composition and microstructure as well as with the osteogenic enhancement of the scaffolds. The nanofibrous scaffold composed of PLA, nHA and MNPs possessed the strongest magnetization, and significantly promoted the osteogenic differentiation of pre-osteoblasts and bone marrow derived mesenchymal stem cells (bMSCs) under magnetic fields, evidenced by the upregulated gene expression of Runx2 and BMP2, the increased ALP activity, OPN and OCN of the cells. The optimal scaffold recruited more bMSCs and enhanced the osteogenic differentiation and the cross talk among the bMSCs, macrophages and fibroblasts under the magnetic field.

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Magnetic targeting of smooth muscle cells in vitro using a magnetic bacterial cellulose to improve cell retention in tissue-engineering vascular grafts

Cited by 62 publications

References 32 publications

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Recent Advances on Magnetic Sensitive Hydrogels in Tissue Engineering

Modulatory Effects of the Composition and Structure on the Osteogenic Enhancement for Superparamagnetic Scaffolds

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