Magnetic targeting of thermosensittve magnetoliposomes to mouse livers in an in situ on-line perfusion system

Viroonchatapan, Ekapop; Sato, Hitoshi; Ueno, Masaki; Adachi, Isao; Tazawa, Kenji; Horikoshi, Isamu

doi:10.1016/0024-3205(96)00220-2

Cited by 63 publications

(33 citation statements)

References 29 publications

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“…One limitation is associated with the influence of the blood flow rate at the target site on the accumulation of MDCPs [2]. While previous studies have shown that it is possible to retain MDCPs in tissues using relatively low magnetic field strengths of 0.01-0:5 T [7,[9][10][11], the feasibility of retaining them in large arteries under similar conditions has not been demonstrated. The linear velocity of blood in large arteries is 50-100 times faster than the blood flow in capillaries, which is about 0:5 cm s À1 [12][13][14]; therefore, it is generally believed that much stronger magnetic fields would be required to retain MDCPs in large arteries [2,15].…”

Section: Article In Pressmentioning

confidence: 97%

“…In fact, previous studies have shown that it is possible to accumulate MDCPs in tissue with an externally applied magnetic field [2,3,[6][7][8][9][10][11]. Despite these promising (but few) studies, there are still several problems associated with magnetic targeting in humans.…”

Section: Article In Pressmentioning

confidence: 98%

“…A typical procedure where magnetic fields are used for targeting drugs, for example in the treatment of cancer, is the direct and non-invasive application of a permanent magnet to the skin located directly over the affected zone in the body [6][7][8][9][10][11]. The magnet creates a magnetic field with intensity H and gradients r H that are supposedly strong enough to retain MDCPs as they pass through a diseased or cancerous region located at some distance below the skin.…”

Section: Hypothetical Magnetic Drug Targeting Systemmentioning

confidence: 99%

“…Incorporating magnetic particles into drug carriers [3][4][5][6] and using an externally applied magnetic field is one way to physically direct these magnetic drug carrier particles (MDCPs) to a site [2,3,[6][7][8][9][10][11].…”

Section: Article In Pressmentioning

confidence: 99%

See 3 more Smart Citations

Application of high gradient magnetic separation principles to magnetic drug targeting

Ritter

Ebner

Daniel

et al. 2004

Journal of Magnetism and Magnetic Materials

172

101

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Section: Article In Pressmentioning

confidence: 97%

Section: Article In Pressmentioning

confidence: 98%

Section: Hypothetical Magnetic Drug Targeting Systemmentioning

confidence: 99%

Section: Article In Pressmentioning

confidence: 99%

See 2 more Smart Citations

Application of high gradient magnetic separation principles to magnetic drug targeting

Ritter

Ebner

Daniel

et al. 2004

Journal of Magnetism and Magnetic Materials

172

101

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“…For this purpose, iron oxide nanoparticles can be encapsulated into phospholipid vesicles to develop liposomal contrast agents (ie, magnetic liposomes [MLs]). [7][8][9][10][11] Here, we have focused our attention on ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs), which have a hydrodynamic diameter of less than 50 nm. In contrast to superparamagnetic iron oxide nanoparticles (SPIOs; diameters between 70 and 150 nm), which are used as T2 contrast agents, USPIOs additionally show a T1 contrast when applied in moderate concentrations.…”

Section: Introductionmentioning

confidence: 99%

Ultrasmall superparamagnetic iron oxide (USPIO)-based liposomes as magnetic resonance imaging probes

Frascione¹,

Almer²,

Opriessnig³

et al. 2012

IJN

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Background: Magnetic liposomes (MLs) are phospholipid vesicles that encapsulate magnetic and/or paramagnetic nanoparticles. They are applied as contrast agents for magnetic resonance imaging (MRI). MLs have an advantage over free magnetic nanocores, in that various functional groups can be attached to the surface of liposomes for ligand-specific targeting. We have synthesized PEG-coated sterically-stabilized magnetic liposomes (sMLs) containing ultrasmall superparamagnetic iron oxides (USPIOs) with the aim of generating stable liposomal carriers equipped with a high payload of USPIOs for enhanced MRI contrast. Methods: Regarding iron oxide nanoparticles, we have applied two different commercially available surface-coated USPIOs; sMLs synthesized and loaded with USPIOs were compared in terms of magnetization and colloidal stability. The average diameter size, morphology, phospholipid membrane fluidity, and the iron content of the sMLs were determined by dynamic light scattering (DLS), transmission electron microscopy (TEM), fluorescence polarization, and absorption spectroscopy, respectively. A colorimetric assay using potassium thiocyanate (KSCN) was performed to evaluate the encapsulation efficiency (EE%) to express the amount of iron enclosed into a liposome. Subsequently, MRI measurements were carried out in vitro in agarose gel phantoms to evaluate the signal enhancement on T1-and T2-weighted sequences of sMLs. To monitor the biodistribution and the clearance of the particles over time in vivo, sMLs were injected in wild type mice. Results: DLS revealed a mean particle diameter of sMLs in the range between 100 and 200 nm, as confirmed by TEM. An effective iron oxide loading was achieved just for one type of USPIO, with an EE% between 74% and 92%, depending on the initial Fe concentration (being higher for lower amounts of Fe). MRI measurements demonstrated the applicability of these nanostructures as MRI probes. Conclusion: Our results show that the development of sMLs is strictly dependent on the physicochemical characteristics of the nanocores. Once established, sMLs can be further modified to enable noninvasive targeted molecular imaging.

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New ferromagnetic bone cement for local hyperthermia

Takegami

Sano

Wakabayashi

et al. 1998

J. Biomed. Mater. Res.

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We have developed a ferromagnetic bone cement as a thermoseed to generate heat by hysteresis loss under an alternate magnetic field. This material resembles bioactive bone cement in composition, with a portion of the bioactive glass ceramic component replaced by magnetite (Fe3O4) powder. The temperature of this thermoseed rises in proportion to the weight ratio of magnetite powder, the volume of the thermoseed, and the intensity of the magnetic field. The heat-generating ability of this thermoseed implanted into rabbit and human cadaver tibiae was investigated by applying a magnetic field with a maximum of 300 Oe and 100 kHz. In this system, it is very easy to increase the temperature of the thermoseed in bone beyond 50 degrees C by adjusting the above-mentioned control factors. When the temperature of the thermoseed in rabbit tibiae was maintained at 50 to 60 degrees C, the temperature at the interface between the bone and muscle (cortical surface) surrounding the material rose to 43 to 45 degrees C; but at a 10-mm distance from the thermoseed in the medullary canal, the temperature did not exceed 40 degrees C. These results demonstrate that ferromagnetic bone cement may be applicable for the hyperthermic treatment of bone tumors.

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Magnetic targeting of thermosensittve magnetoliposomes to mouse livers in an in situ on-line perfusion system

Cited by 63 publications

References 29 publications

Application of high gradient magnetic separation principles to magnetic drug targeting

Application of high gradient magnetic separation principles to magnetic drug targeting

Ultrasmall superparamagnetic iron oxide (USPIO)-based liposomes as magnetic resonance imaging probes

New ferromagnetic bone cement for local hyperthermia

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