Magnetic two-dimensional nanocomposites for multimodal antitumor therapy: a recent review

Yuan, Ying; Chen, Bo; Song, Luping; An, Xingxing; Zhang, Qinrui; Lu, Hao; Li, Chang Ming; Guo, Chunxian

doi:10.1039/d3tb02333h

J. Mater. Chem. B

2024

DOI: 10.1039/d3tb02333h

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Magnetic two-dimensional nanocomposites for multimodal antitumor therapy: a recent review

Ying Yuan,

Bo Chen,

Luping Song

et al.

Abstract: Magnetic two-dimensional nanocomposites (M2D NCs) that synergistically combine magnetic nanomedicines and 2D nanomaterials have emerged in multimodal antitumor therapy, attracting great interest in material science and biomedical engineering. This review...

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2024

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Cited by 4 publications

References 133 publications

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Modulation of Unregulated Inflammation‐Associated Coagulopathy in Sepsis Using Multifunctional Nanosheets

Xiao,

Fang,

Wang

et al. 2024

Adv Funct Materials

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Excessive inflammation‐associated unregulated coagulation leads to disseminated intravascular coagulation (DIC) and mortality in patients with sepsis worldwide, and current clinical treatment is unsatisfactory. Recent studies have shown that circulating cell‐free DNA (cfDNA) and neutrophil extracellular traps (NETs), act as potent pro‐inflammation and pro‐coagulation agents, revealing a mechanistic link between innate immunity and coagulation. After establishing a definite correlation between cfDNA and dysfunctional inflammation and coagulation disorders in samples from patients with sepsis, a novel 2D, sheet‐like, cationic cfDNA scavenger using polyamidoamine (P‐G1) and antimicrobial peptides (AMPs) covered with black phosphorus (BP) nanosheets, called BP‐G1AMP, are fabricated. It is found that BP‐G1AMP significantly suppressed bacterial growth and ameliorated the systemic inflammatory response, associated coagulation disorder, and DIC, resulting in improved survival in a cecal ligation puncture (CLP) mouse sepsis model. This study proposes a novel strategy for fabricating multifunctional nanosheets that can ameliorate inflammation‐associated coagulation during sepsis treatment. These findings demonstrate the importance of 2D nanostructures in the construction of multivalent anti‐bacterial and anti‐coagulation nanoplatforms.

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Modulation of Unregulated Inflammation‐Associated Coagulopathy in Sepsis Using Multifunctional Nanosheets

Xiao,

Fang,

Wang

et al. 2024

Adv Funct Materials

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show abstract

Novel progress of covalent organic frameworks in the biomedicine approaches: From synthesis to cutting edge therapeutics

Moharramnejad,

Sayah,

Ghehsareh

et al. 2024

Journal of Drug Delivery Science and Technology

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Cytotoxicity assessment of Cu0.5Zn0.5Fe2O4 nanoparticles prepared via rapid combustion-calcination process on SGC-7901 and HGC-27 gastric cancer cells

Yue,

Deng,

Wang

et al. 2024

Materials Today Communications

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Magnetic two-dimensional nanocomposites for multimodal antitumor therapy: a recent review

Abstract: Magnetic two-dimensional nanocomposites (M2D NCs) that synergistically combine magnetic nanomedicines and 2D nanomaterials have emerged in multimodal antitumor therapy, attracting great interest in material science and biomedical engineering. This review...

Cited by 4 publications

References 133 publications

Modulation of Unregulated Inflammation‐Associated Coagulopathy in Sepsis Using Multifunctional Nanosheets

Modulation of Unregulated Inflammation‐Associated Coagulopathy in Sepsis Using Multifunctional Nanosheets

Novel progress of covalent organic frameworks in the biomedicine approaches: From synthesis to cutting edge therapeutics

Cytotoxicity assessment of Cu0.5Zn0.5Fe2O4 nanoparticles prepared via rapid combustion-calcination process on SGC-7901 and HGC-27 gastric cancer cells

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