Magnetic β-Cyclodextrin Nanosponges for Potential Application in the Removal of the Neonicotinoid Dinotefuran from Wastewater

Salazar, Sebastián; Yutronic, Nicolás; Jara, Paul

doi:10.3390/ijms21114079

Cited by 31 publications

(25 citation statements)

References 38 publications

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“…None of the characteristic peaks of the anti-tumor drugs are preserved in the NS-MPH and NS-CYT diffraction patterns. This confirms the encapsulation of the drugs inside the cavities of the NSs and the lack of free drugs in the ICs, as reported previously [ 21 , 38 , 45 , 46 , 47 ].…”

Section: Resultssupporting

confidence: 90%

“…It is possible that the drugs were included not only inside the cavities of the CD monomers, but also on the multiple interstices of the NSs that were produced by polymerization. The differences in the chemical shifts of the drugs upon inclusion with NSs confirm the complexation of the drugs, as the occurrence of changes in the micro-environment between the free and entrapped drugs was expected, as reported in previous studies [11,21,[38][39][40].…”

Section: H-nmr Spectra Of the Icssupporting

confidence: 85%

“…The second and main weight loss step was observed at 350 °C, which corresponds to degradation of NSs [ 38 , 41 ]. The thermograms show that the inclusion of MPH and CYT in the cavities of the NSs might increase the thermal stability of the drugs [ 21 , 29 , 41 , 42 , 43 , 44 ]. The decomposition temperatures for MPH, CYT and the ICs are summarized in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

“…NSs main advantages also include that they can be chemically modified and decorated with nanoparticles, thus improving the usefulness and properties of the polymer [ 21 ]. NSs have been proven to be safe, non-toxic, biodegradable, and of low cost [ 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…These results could be of great interest as they contribute to the understanding of the potential utility of NSs associated to AuNPs for the controlled release of drug molecules via local photothermic effects. NSs main advantages also include that they can be chemically modified and decorated with nanoparticles, thus improving the usefulness and properties of the polymer [21]. NSs have been proven to be safe, non-toxic, biodegradable, and of low cost [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan

Salazar

Yutronic

Kogan

et al. 2021

IJMS

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This article describes the synthesis and characterization of β-cyclodextrin-based nano-sponges (NS) inclusion compounds (IC) with the anti-tumor drugs melphalan (MPH) and cytoxan (CYT), and the addition of gold nanoparticles (AuNPs) onto both systems, for the potential release of the drugs by means of laser irradiation. The NS-MPH and NS-CYT inclusion compounds were characterized using scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), energy dispersive spectroscopy (EDS), thermogravimetric analysis (TGA), UV–Vis, and proton nuclear magnetic resonance (1H-NMR). Thus, the inclusion of MPH and CYT inside the cavities of NSs was confirmed. The association of AuNPs with the ICs was confirmed by SEM, EDS, TEM, and UV–Vis. Drug release studies using NSs synthesized with different molar ratios of β-cyclodextrin and diphenylcarbonate (1:4 and 1:8) demonstrated that the ability of NSs to entrap and release the drug molecules depends on the crosslinking between the cyclodextrin monomers. Finally, irradiation assays using a continuous laser of 532 nm showed that photothermal drug release of both MPH and CYT from the cavities of NSs via plasmonic heating of AuNPs is possible.

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Section: Resultssupporting

confidence: 90%

Section: H-nmr Spectra Of the Icssupporting

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan

Salazar

Yutronic

Kogan

et al. 2021

IJMS

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Nanosponges as an Emerging Platform for Cancer Treatment and Diagnosis

Gowda,

Ahmed,

Almoyad

et al. 2023

Adv Funct Materials

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Nanosponges are unique sponge‐like carrier systems with numerous cavities and a mesh‐like network throughout their surface. They are categorized into three types based on the material of construction, i.e., polymer‐, inorganic‐, and bio‐derived material‐based nanosponges. Unlike conventional nanoparticles, nanosponges bear countless interconnected voids and mesh‐like network that enables maximum drug, imaging probe, or photosensitizer loading via absorption, encapsulation, conjugation, or complexion. The voids can be further sealed using suitable lipids or polymers to avoid leakage of drugs at the non‐target site, protect therapeutics from biological conditions, and control the release of therapeutics for a prolonged period. Recently, nanosponges have grasped the attention of researchers in the area of cancer by overcoming the drawbacks associated with the conventional delivery of immunotherapeutic, targeted therapeutic, and chemotherapeutic agents. Interestingly, several reports have also witnessed their potential in cancer theranostics. Owing to this supremacy, nanosponges could be an apt platform for cancer therapy and diagnosis. The current review discusses the general aspects, types, and preparation methods of nanosponges. In addition, the ambit of nanosponges in treating different types of cancer is meticulously discussed, along with detailed descriptions of their corresponding patents. Furthermore, the role of nanosponges in phototherapy and cancer theranostics are selectively canvassed.

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