Magnetically controlled flexible valve for flow manipulation in polymer microfluidic devices

Bute, Madhushree; Sheikh, Arif D.; Mathe, V. L.; Bodas, Dhananjay; Karekar, R.N.; Gosavi, Suresh

doi:10.1109/ispts.2012.6260969

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…Both the chambers were sealed using a thin glass cover. PDMS-magnetic needle (Figure 2e) was fabricated 34 as detailed in the Supporting Information (page S-1).…”

Section: Methodsmentioning

confidence: 99%

Synthesis of Monodisperse Chitosan Nanoparticles and in Situ Drug Loading Using Active Microreactor

Kamat

Marathe

Ghormade

et al. 2015

ACS Appl. Mater. Interfaces

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Chitosan nanoparticles are promising drug delivery vehicles. However, the conventional method of unregulated mixing during ionic gelation limits their application because of heterogeneity in size and physicochemical properties. Therefore, a detailed theoretical analysis of conventional and active microreactor models was simulated. This led to design and fabrication of a polydimethylsiloxane microreactor with magnetic micro needles for the synthesis of monodisperse chitosan nanoparticles. Chitosan nanoparticles synthesized conventionally, using 0.5 mg/mL chitosan, were 250 ± 27 nm with +29.8 ± 8 mV charge. Using similar parameters, the microreactor yielded small size particles (154 ± 20 nm) at optimized flow rate of 400 μL/min. Further optimization at 0.4 mg/mL chitosan concentration yielded particles (130 ± 9 nm) with higher charge (+39.8 ± 5 mV). The well-controlled microreactor-based mixing generated highly monodisperse particles with tunable properties including antifungal drug entrapment (80%), release rate, and effective activity (MIC, 1 μg/mL) against Candida.

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“…Both the chambers were sealed using a thin glass cover. PDMS-magnetic needle (Figure 2e) was fabricated 34 as detailed in the Supporting Information (page S-1).…”

Section: Methodsmentioning

confidence: 99%

Synthesis of Monodisperse Chitosan Nanoparticles and in Situ Drug Loading Using Active Microreactor

Kamat

Marathe

Ghormade

et al. 2015

ACS Appl. Mater. Interfaces

Self Cite

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“…In the presence of a small NdFeB magnet lying below the channel of interest, the metal bar is pulled downward simultaneously pushing the thin layer of PDMS down thereby closing the channel and stopping any flow of fluid. Furthermore, Bute et al [121] reported that the flow manipulation and proper operation of the valve depends on thickness and percentage load of magnetic material in the membrane as well as dimensions of channel, chamber and membrane with respect to the location of outlet channels, while Nakahara et al [122] reported the use of photosensitive polymer composites for the fabrication of magnetically driven microvalve arrays in a µTAS (µ-total analysis system)…”

Section: Polymer-based Electromagnetic Actuators For Micropumps and Microvalvesmentioning

confidence: 99%

Polymer-Based MEMS Electromagnetic Actuator for Biomedical Application: A Review

et al. 2020

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In this study, we present a comprehensive review of polymer-based microelectromechanical systems (MEMS) electromagnetic (EM) actuators and their implementation in the biomedical engineering field. The purpose of this review is to provide a comprehensive summary on the latest development of electromagnetically driven microactuators for biomedical application that is focused on the movable structure development made of polymers. The discussion does not only focus on the polymeric material part itself, but also covers the basic mechanism of the mechanical actuation, the state of the art of the membrane development and its application. In this review, a clear description about the scheme used to drive the micro-actuators, the concept of mechanical deformation of the movable magnetic membrane and its interaction with actuator system are described in detail. Some comparisons are made to scrutinize the advantages and disadvantages of electromagnetic MEMS actuator performance. The previous studies and explanations on the technology used to fabricate the polymer-based membrane component of the electromagnetically driven microactuators system are presented. The study on the materials and the synthesis method implemented during the fabrication process for the development of the actuators are also briefly described in this review. Furthermore, potential applications of polymer-based MEMS EM actuators in the biomedical field are also described. It is concluded that much progress has been made in the material development of the actuator. The technology trend has moved from the use of bulk magnetic material to using magnetic polymer composites. The future benefits of these compact flexible material employments will offer a wide range of potential implementation of polymer composites in wearable and portable biomedical device applications.

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Section: Polymer-based Electromagnetic Actuators For Micropumps and Microvalvesmentioning

confidence: 99%

Functional Polymers in Sensors and Actuators: Fabrication and Analysis

2020

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Magnetically controlled flexible valve for flow manipulation in polymer microfluidic devices

Cited by 3 publications

References 30 publications

Synthesis of Monodisperse Chitosan Nanoparticles and in Situ Drug Loading Using Active Microreactor

Synthesis of Monodisperse Chitosan Nanoparticles and in Situ Drug Loading Using Active Microreactor

Polymer-Based MEMS Electromagnetic Actuator for Biomedical Application: A Review

Functional Polymers in Sensors and Actuators: Fabrication and Analysis

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