Magnetically Engineered Smart Thin Films: Toward Lab-on-Chip Ultra-Sensitive Molecular Imaging

Abstract

Magnetically responsive engineered smart thin films of nanoferrites as contrast agent are employed to develop surface based magnetic resonance imaging to acquire simple yet fast molecular imaging. The work presented here can be of significant potential for future lab-on-chip point-of-care diagnostics from the whole blood pool on almost any substrates to reduce or even prevent clinical studies involve a living organism to enhance the non-invasive imaging to advance the '3Rs' of work in animals-replacement, refinement and reduction.

Magnetic Colloidal Particles in Combinatorial Thin-Film Gradients for Magnetic Resonance Imaging and Hyperthermia

“…The number of adsorption sites increased with the number of bilayers indicated the increase in thickness and roughness of the surface [13,43]. As a consequence, an increase in the number of deposited colloidal particles with the increase in the number of bilayers leads to the increase in surface roughness along the substrate for 5, 10, and 15 bilayers; this is in agreement with the reported literature [12,13]. is lower as compared to 5, 10, and 15 bilayers, and that anomaly may be attributed to various factors that affect the resolution of the surface roughness measurement.…”

“…A broad range of stimuliresponsive thin films have been fabricated and are used as a point-of-care diagnostic devices that can be routinely applied in everyday clinical practice. Thin films of nickel ferrites and chitosan were fabricated by the LBL technique and investigated for their ability to generate an intensity difference using blood as a test liquid; however, T1 and T2 images were not explored in detail [12]. Using the same manual fabrication protocol, thin films were designed, fabricated, and characterized but the magnetic behavior of the films was not tested [13].…”

Co‐encapsulating CoFe 2 O 4 and MTX for hyperthermia

“…Bare CoFe 2 O 4 lowered temperature between bearable ranges for the human body, i.e. 42–47°C [44–46]. Such results could contribute towards the improved treatments of cancer cells, without harming the healthy tissues.…”

pH Tunable Thin Film Gradients of Magnetic Polymer Colloids for MRI Diagnostics

“…Layer-by-layer (LBL) assembly of oppositely charged polyelectrolytes on colloidal particles has recently been used to generate novel nano-and microcapsules with variable characteristics. Thin films of nickel ferrites and chitosan were fabricated by the LBL technique and investigated for their ability to generate an intensity difference using blood as a test liquid, however, T1 and T2 images were not explored in detail [17]. Using the same manual fabrication protocol, thin films were designed, fabricated and characterized but the magnetic behavior of the films was not tested [18].…”