Magnetite nanoparticle coated with amphiphilic bilayer surfactant of polysiloxane and poly(poly(ethylene glycol) methacrylate)

Thong-On, Bandit; Rutnakornpituk, Boonjira; Wichai, Uthai; Rutnakornpituk, Metha

doi:10.1007/s11051-012-0953-y

Cited by 22 publications

(6 citation statements)

References 34 publications

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“…The most common ones are ligand addition, ligand exchange, and hydrophilic silica coating. In the ligand addition method, an amphiphilic molecule, that owns a hydrophilic and a hydrophobic group, is used in order to increase the MNPs water solubility [213]. The ligand exchange way is achieved through the use of a new type of coordinating group that links tightly to the surface thanks to chemical bonding and replaces the hydrocarbon layer [214].…”

Section: Magnetic Responsive Nanomaterialsmentioning

confidence: 99%

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Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

Municoy

Echazú

Antezana

et al. 2020

IJMS

156

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Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues.

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Section: Magnetic Responsive Nanomaterialsmentioning

confidence: 99%

“…group, is used in order to increase the MNPs water solubility [213]. The ligand exchange way is achieved through the use of a new type of coordinating group that links tightly to the surface thanks to chemical bonding and replaces the hydrocarbon layer [214].…”

Section: Magnetic Responsive Nanomaterialsmentioning

confidence: 99%

Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

Municoy

Echazú

Antezana

et al. 2020

IJMS

156

View full text Add to dashboard Cite

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“…Nanotechnology is one of the fastest growing fields in fundamental and applied science [1][2][3] due to the unique physical and chemical properties demonstrated at the nanoscale [4]. Nanoparticles of both metals and nonmetals are used, e.g., as semiconductors [5,6], adsorbents for water purification [7], biosensors [8,9] and components of anticancer drugs [10,11].…”

Section: Introductionmentioning

confidence: 99%

Mixed Systems Based on Erucyl Amidopropyl Betaine and Nanoparticles: Self‐Organization and Rheology

Gaynanova

Valiakhmetova

Kuryashov

et al. 2015

J Surfact & Detergents

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The aggregation behavior and flow characteristics of systems based on zwitterionic surfactant, erucyl amidopropyl betaine, silica and alumina nanoparticles in a wide range of surfactant concentrations from molecular to micellar solutions were studied using surface tensiometry, conductometry, dynamic and electrophoretic light scattering, and rheology techniques. The adsorption of zwitterionic surfactant molecules occurs on both positively and negatively charged surfaces via an electrostatic interaction mechanism. As a result, addition of a small amount silica nanoparticles (0.5-0.8 wt%) increases the surfactant solution's viscosity by more than two times.

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“…Adsorption of small molecules, such as citric acid, fatty acids (especially the oleic acid), amino acids, various natural molecules (e.g., lecithin) and their combination have been applied to cover magnetic nanoparticles [1,[11][12][13][14][15][16][17][18][19][20][21][22]. Biocompatible SPION coating can be also achieved by using macromolecules, e.g., homopolymers (PVA, PVP, PAA, PEG (polyethylene-glycol)) [10,16,18,19,[23][24][25][26][27][28], copolymers (PEO-PPO(polypropylene oxide)-PEO (also known as Pluronics)) [4,29] or natural polymers (gelatine, polysaccharides, dextran) [11,21]. Even though the coating of nanomagnets with different surface modifiers leads to adequate stabilization, the blood plasma proteins can be adsorbed on their surfaces labelling them for opsonisation.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, the hydrophilic coating increases the retention time of nanomagnets in the circulation system. According to literature sources, two main methods of PEGylation prevail [2,3,7,25]. The first is physico-chemical binding of PEG or functionalized PEG to the bare or previously modified (usually oleate covered) surface of magnetite.…”

Section: Introductionmentioning

confidence: 99%

PEGylation of surfacted magnetite core–shell nanoparticles for biomedical application

Illés

Szekeres

Kupcsik

et al. 2014

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Corresponding authors: E. Illés (illese@chem.hu) and E. Tombácz (tombacz@chem.u-szeged.hu) Elsevier ECIS2013 Best Poster Prize awarded contribution Present address: A. Jedlovszky-Hajdú, Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, H-1089 Budapest, Nagyvárad tér 4, Hungary. Graphical abstract Highlights• The mechanisms of oleate adsorption on as-synthesized and purified MNPs are different.• PEG adsorption increases the weight of steric component in electrosteric stabilization by oleate.• MNPs become clustered upon OA adsorption; cluster size is larger for as-synthesized MNPs.• PEG-surfacted MNPs do not show cytotoxicity and hemolytic potential on human blood.• MRI T2 enhancement of as-synthesized MNPs supports higher degree of clustering. AbstractThe surface of oleate double layer coated (surfacted) magnetite nanoparticles (OA@MNPs) was coated by PEG (poly(ethylene glycol) of Mw=1000, 4000 or 20000 Da, respectively, to get core-shell structured nanomagnets. The oleate bilayers were prepared in two different ways; (i) oleic acid was added directly into the magnetite co-precipitation mixture containing the MNPs to obtain OA@s-MNP samples -s-MNP standing for "as-synthesized MNP" and (ii) sodium oleate (oleate anion, OA) was added to the purified MNPs to obtain OA@p-MNP samples -p-MNP standing for "purified MNP". The effect of the surfactant addition method on the pH-and ionic strength-dependent stability (dynamic laser light scattering and laser-Doppler electrophoresis experiments), the biomedical applicability (MRI measurements) and the biocompatibility (blood sedimentation and blood smear tests) of the coreshell MNPs was studied. Different mechanisms of oleate adsorption were found in ATR FT-IR experiments (inner sphere surface complexation via ligand exchange for the s-MNPs and additional H-bonding for the p-MNPs), suggesting different behaviour. The colloidal stability and salt tolerance of the two kinds of OA@MNPs were similar, but the hydrodynamic diameter of the OA@s-MNP was considerably larger than that of OA@p-MNP. In accordance with this, the r2 relaxation was also higher for the s-MNP samples (~400 and ~ 200 mM -1 s -1 , respectively). The physico-chemical tests indicate that the OA-coated MNPs form clusters and the degree of clustering of OA@s-MNPs is significantly 2 greater than that of OA@p-MPNs. PEGylation does not appear to affect colloidal stability and salt tolerance meaningfully. The adsorption of PEG was proved experimentally. We have found that the PEG top layer decreases the electrostatic contribution, nevertheless increases the steric contribution of the original electrosteric stabilization caused by the OA double layer. However, an increase in the molecular weight above 1000 Da and the amount of added PEG above 5 mmol/g gradually reduces the salt tolerance of the samples. The results indicate strong potential for biomedical application and biocompatibility of the PEGylated MNPs.

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Magnetite nanoparticle coated with amphiphilic bilayer surfactant of polysiloxane and poly(poly(ethylene glycol) methacrylate)

Cited by 22 publications

References 34 publications

Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

Mixed Systems Based on Erucyl Amidopropyl Betaine and Nanoparticles: Self‐Organization and Rheology

PEGylation of surfacted magnetite core–shell nanoparticles for biomedical application

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