Magnetite nanoparticles for medical MR imaging

Stephen, Zachary R.; Kievit, Forrest M.; Zhang, Miqin

doi:10.1016/s1369-7021(11)70163-8

Cited by 391 publications

(292 citation statements)

References 87 publications

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“…Magnetite nanoparticles have been of great interest as new MRI contrast agents, largely due to their ease of synthesis, biocompatibility and superparamagnetism [68]. The magnetic plasmonic nanoclusters synthesised by Wu et al are proposed for use as multimodal imaging agents, utilising magnetic guidance under monitoring of the image in situ [40].…”

Section: Imaging and Contrast Agentsmentioning

confidence: 99%

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

2018

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Magnetic plasmonic nanomaterials are of great interest in the field of biomedicine due to their vast number of potential applications, for example, in molecular imaging, photothermal therapy, magnetic hyperthermia and as drug delivery vehicles. The multimodal nature of these nanoparticles means that they are potentially ideal theranostic agents-i.e., they can be used both as therapeutic and diagnostic tools. This review details progress in the field of magnetic-plasmonic nanomaterials over the past ten years, focusing on significant developments that have been made and outlining the future work that still needs to be done in this fast emerging area. The review describes the main synthetic approaches to each type of magnetic plasmonic nanomaterial and the potential biomedical applications of these hybrid nanomaterials.

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Section: Imaging and Contrast Agentsmentioning

confidence: 99%

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

2018

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“…Upon removal of the radiation, the magnetic moments of the protons relax to equilibrium. 15 In MRI, this process is repeated in a quick succession of RF pulses. The time taken by the magnetic moments to return to their original alignment with the magnetic field is called the relaxation time, and it is tissue dependent.…”

Section: Magnetic Resonance Imaging: Origin Of the Contrastmentioning

confidence: 99%

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Estelrich¹,

Sánchez-Martín²,

Busquets³

2015

IJN

281

106

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Magnetic resonance imaging (MRI) has become one of the most widely used and powerful tools for noninvasive clinical diagnosis owing to its high degree of soft tissue contrast, spatial resolution, and depth of penetration. MRI signal intensity is related to the relaxation times ( T 1 , spin–lattice relaxation and T 2 , spin–spin relaxation) of in vivo water protons. To increase contrast, various inorganic nanoparticles and complexes (the so-called contrast agents) are administered prior to the scanning. Shortening T 1 and T 2 increases the corresponding relaxation rates, 1/ T 1 and 1/ T 2 , producing hyperintense and hypointense signals respectively in shorter times. Moreover, the signal-to-noise ratio can be improved with the acquisition of a large number of measurements. The contrast agents used are generally based on either iron oxide nanoparticles or ferrites, providing negative contrast in T 2 -weighted images; or complexes of lanthanide metals (mostly containing gadolinium ions), providing positive contrast in T 1 -weighted images. Recently, lanthanide complexes have been immobilized in nanostructured materials in order to develop a new class of contrast agents with functions including blood-pool and organ (or tumor) targeting. Meanwhile, to overcome the limitations of individual imaging modalities, multimodal imaging techniques have been developed. An important challenge is to design all-in-one contrast agents that can be detected by multimodal techniques. Magnetoliposomes are efficient multimodal contrast agents. They can simultaneously bear both kinds of contrast and can, furthermore, incorporate targeting ligands and chains of polyethylene glycol to enhance the accumulation of nanoparticles at the site of interest and the bioavailability, respectively. Here, we review the most important characteristics of the nanoparticles or complexes used as MRI contrast agents.

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“…Moreover, they can also respond resonantly to an alternating magnetic field and induce heating, therefore being of interest for magnetic-induced hyperthermia [8][9][10]. MRI is considered one of the most promising non-invasive diagnostic tool in medical science since it provides 3D anatomical images with high spatial resolution in the submillimeter range and high soft tissue contrast [11]. Several SPION preparations have been approved by US FDA for clinical use as magnetic resonance (MR) CAs, such as Endorem R for liver imaging [12].…”

Section: Introductionmentioning

confidence: 99%

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

et al. 2017

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Aim:To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T 2 magnetic resonance contrast agent and their uptake and toxicity in liver. Materials & methods: Mice were intravenously injected with bioferrofluids and Endorem R . The magnetic resonance efficiency, uptake and in vivo toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques. Results: Bioferrofluids are a good T 2 contrast agent with a higher r 2 /r 1 ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection. Conclusion: Our bioferrofluids are powerful diagnostic tool without any observed toxicity over a period of 60 days post-injection.Lay abstract: Several superparamagnetic iron oxide nanoparticles (SPIONs) preparations have been approved by US FDA for clinical use as MRI contrast agents. In recent years, we have been developing a synthetic multifunctional platform for SPIONs based on the use of polymers. In this report, we explored the diagnostic potential of these nanoparticles (herein called bioferrofluids) as an MRI contrast agent and their uptake in liver, without neglecting their toxicological effects. Results show that our bioferrofluids are a good T 2 contrast agent without any observed toxicity in liver.

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Magnetite nanoparticles for medical MR imaging

Cited by 391 publications

References 87 publications

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

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Magnetite nanoparticles for medical MR imaging

Cited by 391 publications

References 87 publications

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T 2 Contrast Agent for MRI and their Uptake in Liver

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Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver