Magneto acoustic tomography with short pulsed magnetic field for in-vivo imaging of magnetic iron oxide nanoparticles

Abstract

Nanoparticles are widely used as contrast and therapeutic agents. As such, imaging modalities that can accurately estimate their distribution in-vivo are actively sought. We present here our method Magneto Acoustic Tomography (MAT), which uses magnetomotive force due to a short pulsed magnetic field to induce ultrasound in the magnetic nanoparticle labeled tissue and estimates an image of the distribution of the nanoparticles in-vivo with ultrasound imaging resolution. In this study, we image the distribution of superparamagnetic iron oxide nanoparticles (IONP) using MAT method. In-vivo imaging was performed on live, nude mice with IONP injected into lymph node derived cancer of the prostate tumors induced over the hind limb of the mice. Our experimental results indicate that the MAT method is capable of imaging the distribution of IONPs in-vivo. Therefore, MAT could become an imaging modality for high resolution reconstruction of MNP distribution in the body.

Simulation Study on Forward Problem of Magnetoacoustic Tomography With Magnetic Induction Based on Magnetic Nanoparticles

“…In 2016, Mariappan and others successfully detected and reconstructed the MNPs distribution in mice with MNPs in vivo using MAT-MI. The experiment proved that the MAT-MI based on MNPs had good resolution and imaging depth [12]. In 2018, Yan and other researchers studied the influence of MNPs on MAT-MI from a theoretical point of view and determined that MNPs can make the reconstruction of sound sources more convenient because MNPs can produce more sound pressure signals and more uniform sound pressure distribution than traditional MAT-MI.…”

Magnetoacoustic tomography with magnetic induction (MAT-MI) for imaging electrical conductivity of biological tissue: a tutorial review

“…The most possible clinical application of MAT-MI is believed to be tumor detection especially in cancer screening and detection. A recent work on magneto acoustic tomography with the aid of magnetic nanoparticles suggested such possibility; employing the magnetomotive force, magneto acoustic tomography in a MAT-MI compatible setup was demonstrated as a high-spatial-resolution approach to reconstruct the in vivo distributions of nanoparticles, and to further highlight tumor by a high contrast (Mariappan et al, 2016). This study sheds light on the possibility of improving magnetoacoustic imaging by harnessing the versatility of nanoparticles.…”

<p>Magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer</p>

“…Magnetic nanoparticles (NPs) with good superparamagnetic behavior have attracted much attention, due to their inherent material properties and huge potential in cancer diagnosis [9][10][11] and treatment. 12 Our previous studies have demonstrated that thermosensitive hydrogel systems including Fe 3 O 4 magnetic NPs prolonged the retention of chemotherapy drugs in bladders with external magnets.…”