Magneto-photo-acoustic imaging

Qu, Min; Mallidi, Srivalleesha; Mehrmohammadi, Mohammad; Truby, Ryan L.; Homan, Kimberly A.; Joshi, Pratixa P.; Chen, Yun Sheng; Sokolov, Konstantin; Emelianov, Stanislav

doi:10.1364/boe.2.000385

Cited by 67 publications

(66 citation statements)

References 21 publications

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“…These particles can be used to couple PA imaging with magnetic resonance imaging (MRI) or magnetomotive ultrasound (MMUS) imaging. Nanostars, 117 nanoroses, 61 pearl necklaces, 111 nanowantons, 6 iron oxide and gold-coupled core-shell nanoparticles, 36 and liposomes containing iron oxide nanospheres and gold nanorods 84 have all been developed. Other nanoparticles have recently been synthesized which produce contrast in US and PA imagings.…”

Section: Multi-modal Contrast Agentsmentioning

confidence: 99%

“…4e, 4f). 36,84 Similar techniques have been proposed to trap circulating tumor cells in the blood stream or lymphatic system. 17,35 CONCLUSIONS PA imaging shows great promise for use in a wide array of clinical procedures, ranging from diagnosis to therapy guidance.…”

Section: Multi-modal Imagingmentioning

confidence: 99%

“…(c) PA and (d) US images of a poly(acrylamide) phantom containing a circular inclusion of PAnDs show their ability to generate contrast in both modalities 119. (e) US and (f) US/MPA images of gelatin phantoms containing plasmonic and magnetic nanoparticles show that MPA imaging can be used to detect nanoparticles with high sensitivity and specificity 84. All figures are adapted with permission.…”

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confidence: 99%

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Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents

2011

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Photoacoustic imaging is a biomedical imaging modality that provides functional information, and, with the help of exogenous contrast agents, cellular and molecular signatures of tissue. In this article, we review the biomedical applications of photoacoustic imaging assisted with exogenous contrast agents. Dyes, noble metal nanoparticles, and other constructs are contrast agents which absorb strongly in the near-infrared band of the optical spectrum and generate strong photoacoustic response. These contrast agents, which can be specifically targeted to molecules or cells, have been coupled with photoacoustic imaging for preclinical and clinical applications ranging from detection of cancer cells, sentinel lymph nodes, and micrometastasis to angiogenesis to characterization of atherosclerotic plaques. Multi-functional agents have also been developed, which can carry drugs or simultaneously provide contrast in multiple imaging modalities. Furthermore, contrast agents were used to guide and monitor the therapeutic procedures. Overall, photoacoustic imaging shows significant promise in its ability to assist in diagnosis, therapy planning, and monitoring of treatment outcome for cancer, cardiovascular disease, and other pathologies.

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Section: Multi-modal Contrast Agentsmentioning

confidence: 99%

Section: Multi-modal Imagingmentioning

confidence: 99%

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confidence: 99%

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Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents

2011

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“…For example, magneto-plasmonic nanoparticles were used to increase contrast in dark-field imaging of labeled cells by applying a temporal signal modulation via an external electromagnet [3][4][5] . More recently, a similar principle was applied in development of a new imaging modality -magneto-photoacoustic imaging, where magneto-plasmonic nanoparticles enable great improvements in contrast and signal-to-background ratio 6,7 . It was also shown that the hybrid nanoparticles can be used for simultaneous capture and detection of circulating tumor cells in whole blood and in vivo 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Sokolov

2014

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Magnetic and plasmonic properties combined in a single nanoparticle provide a synergy that is advantageous in a number of biomedical applications including contrast enhancement in novel magnetomotive imaging modalities, simultaneous capture and detection of circulating tumor cells (CTCs), and multimodal molecular imaging combined with photothermal therapy of cancer cells. These applications have stimulated significant interest in development of protocols for synthesis of magneto-plasmonic nanoparticles with optical absorbance in the near-infrared (NIR) region and a strong magnetic moment. Here, we present a novel protocol for synthesis of such hybrid nanoparticles that is based on an oil-in-water microemulsion method. The unique feature of the protocol described herein is synthesis of magneto-plasmonic nanoparticles of various sizes from primary blocks which also have magneto-plasmonic characteristics. This approach yields nanoparticles with a high density of magnetic and plasmonic functionalities which are uniformly distributed throughout the nanoparticle volume. The hybrid nanoparticles can be easily functionalized by attaching antibodies through the Fc moiety leaving the Fab portion that is responsible for antigen binding available for targeting. Video LinkThe video component of this article can be found at

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“…Similar ideas using hybrid contrast agents with magnetic properties have also been proposed for US and PA imaging. 22,23 In previous results from our laboratory, micro-scale magnetic particles (MMPs) were used to mimic magnetic contrast agent targeted cells in a blood vessel. [19][20][21] In the current study, nanometer-scale composite contrast agents consisting of a highly optical absorptive gold nanorod (GNR) coupled with magnetic nanospheres (MNSs) were chemically linked (i.e., targeted) to micro-scale beads mimicking CTCs.…”

Section: Introductionmentioning

confidence: 99%

Trapping and dynamic manipulation of polystyrene beads mimicking circulating tumor cells using targeted magnetic/photoacoustic contrast agents

et al. 2012

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Abstract. Results on magnetically trapping and manipulating micro-scale beads circulating in a flow field mimicking metastatic cancer cells in human peripheral vessels are presented. Composite contrast agents combining magneto-sensitive nanospheres and highly optical absorptive gold nanorods were conjugated to micro-scale polystyrene beads. To efficiently trap the targeted objects in a fast stream, a dual magnet system consisting of two flat magnets to magnetize (polarize) the contrast agent and an array of cone magnets producing a sharp gradient field to trap the magnetized contrast agent was designed and constructed. A water-ink solution with an optical absorption coefficient of 10 cm −1 was used to mimic the optical absorption of blood. Magnetomotive photoacoustic imaging helped visualize bead trapping, dynamic manipulation of trapped beads in a flow field, and the subtraction of stationary background signals insensitive to the magnetic field. The results show that trafficking micro-scale objects can be effectively trapped in a stream with a flow rate up to 12 ml∕ min and the background can be significantly (greater than 15 dB) suppressed. It makes the proposed method very promising for sensitive detection of rare circulating tumor cells within high flow vessels with a highly absorptive optical background.

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Magneto-photo-acoustic imaging

Cited by 67 publications

References 21 publications

Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents

Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Trapping and dynamic manipulation of polystyrene beads mimicking circulating tumor cells using targeted magnetic/photoacoustic contrast agents

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