Magneto-Responsive Scaffolds for Tissue Engineering Applications

Adedoyin, Adedokun A.; Ekenseair, Adam K.

doi:10.1201/9780429295010-16

Cited by 2 publications

(2 citation statements)

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“…It has been shown that magneto-responsive materials are able to stimulate cell growth, proliferation and differentiation [ 26 , 27 ]. The potential applications of magneto-responsive materials for biomedical and tissue engineering applications have been summarized in recent reviews [ 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications

et al. 2022

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Novel hybrid magnetoactive composite scaffolds based on poly(3-hydroxybutyrate) (PHB), gelatin, and magnetite (Fe3O4) were fabricated by electrospinning. The morphology, structure, phase composition, and magnetic properties of composite scaffolds were studied. Fabrication procedures of PHB/gelatin and PHB/gelatin/Fe3O4 scaffolds resulted in the formation of both core-shell and ribbon-shaped structure of the fibers. In case of hybrid PHB/gelatin/Fe3O4 scaffolds submicron-sized Fe3O4 particles were observed in the surface layers of the fibers. The X-ray photoelectron spectroscopy results allowed the presence of gelatin on the fiber surface (N/C ratio–0.11) to be revealed. Incubation of the composite scaffolds in saline for 3 h decreased the amount of gelatin on the surface by more than ~75%. The differential scanning calorimetry results obtained for pure PHB scaffolds revealed a characteristic melting peak at 177.5 °C. The presence of gelatin in PHB/gelatin and PHB/gelatin/Fe3O4 scaffolds resulted in the decrease in melting temperature to 168–169 °C in comparison with pure PHB scaffolds due to the core-shell structure of the fibers. Hybrid scaffolds also demonstrated a decrease in crystallinity from 52.3% (PHB) to 16.9% (PHB/gelatin) and 9.2% (PHB/gelatin/Fe3O4). All the prepared scaffolds were non-toxic and saturation magnetization of the composite scaffolds with magnetite was 3.27 ± 0.22 emu/g, which makes them prospective candidates for usage in biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications

et al. 2022

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“…These MNPs are either blended ("doped") into the respective polymers prior to scaffold fabrication, introduced as a coating post-fabrication via covalently bonding to the biomaterial surface, or precipitated out of aqueous metal ion solutions and deposited onto the scaffold during fabrication ("in situ precipitation"). [2,8,[15][16][17][18] For biomedical applications, MNPs are traditionally synthesized from ironbased oxides, particularly magnetite (Fe 3 O 4 ) or its oxidized form, maghemite (𝛾-Fe 2 O 3 ). [19][20][21] Relative to other metal oxides, ironbased oxides exhibit particularly high magnetic saturation levels (i.e., high magnetic moment per unit volume) that impart significant magneto-responsiveness to functionalized scaffolds with limited increase in metal content.…”

Section: Introductionmentioning

confidence: 99%

Iron‐Chelated Silk Microfibers as a Novel Magneto‐Responsive Architecture for In Situ Aligning Biomaterial Scaffolds

Wojnowski,

Martin,

Kanber

et al. 2023

Adv Funct Materials

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Magnetically functionalized biomaterials represent an exciting prospect in the development of stimuli‐responsive tissue engineering scaffolds. Magneto‐responsive properties are traditionally imparted to scaffold systems via integration of iron oxide‐based magnetic nanoparticles (MNPs), yet poor understanding of long‐term MNP toxicity presents a significant translational challenge. Given the demonstrated iron‐binding capacity of silk fibroin (SF), passive chelation of ferric iron ions is explored herein as an alternative, MNP‐free approach for magnetic functionalization of silk fibroin (SF)‐based biomaterials. SF microfibers treated with aqueous ferric chloride (FeCl3) exhibit significantly increased iron content relative to the nascent protein. Coupled with the absence of detectable chlorine traces and inorganic iron oxide species, the ferric oxidation state of the iron detected within the FeCl3‐treated microfibers suggests that iron is incorporated, without reduction, at innate oxygen‐containing ligands in SF. On exposure to an external magnetic field, these ferric iron‐chelated SF microfibers (Fe3+‐mSF) display paramagnetic magnetization behaviors that facilitate field‐parallel alignment. Both magnetization and directional uniformity increase with iron exposure during FeCl3 treatment, suggesting the observed magnetic response of Fe3+‐mSF is derived from the chelated iron. This work is the first to investigate the magneto‐responsive properties and biocompatibility of ferric iron‐chelated SF, highlighting a novel, MNP‐free mechanism for synthesizing magnetically functionalizedscaffolds.

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Magneto-Responsive Scaffolds for Tissue Engineering Applications

Cited by 2 publications

References 1 publication

Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications

Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications

Iron‐Chelated Silk Microfibers as a Novel Magneto‐Responsive Architecture for In Situ Aligning Biomaterial Scaffolds

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