Magneto-sensitive hybrid nanocomposites of water-soluble sodium alginate cross-linked with calcium ions and maghemite

“…The nanocomposites were prepared using the approach developed earlier for the synthesis of magnetic materials composed magneto‐ordered Fe 3+ ‐oxide nanoparticles with oligo‐ and polysaccharides . Contain of iron was defined as it was described, for example, as in the previous work …”

Section: Methodsmentioning

confidence: 99%

Doxorubicin Loaded Magnetosensitive Water‐Soluble Nanogel Based on NIPAM and Iron (3+) Containing Nanoparticles

Спиридонов

Панова

Kusaia

et al. 2020

Macromolecular Symposia

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“…Synthesis of the magnetic binary composites was conducted using a previously described protocol [16,30]. The magnetic Fe-containing particles were produced from Mohr's salt in the presence of HYAL in an alkaline aqueous solution at room temperature.…”

Section: Synthesis Of the Magnetic Binary Compositesmentioning

confidence: 99%

“…When constructing the conjugates, nanosized particles of iron oxides are widely used because of their high magnetic susceptibility and low toxicity [13,14]. In order to stabilize the magnetic nanoparticles against aggregation, they are embedded into a water-soluble anionic polymer matrix, for example, synthetic polyacrylic acid or native polysaccharides [15,16].…”

Section: Introductionmentioning

confidence: 99%

Magnetically Controlled Hyaluronic Acid–Maghemite Nanocomposites with Embedded Doxorubicin

Spiridonov,

Zoirova,

Alyokhina

et al. 2023

Polymers

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The controllable delivery of drugs is a key task of pharmacology. For this purpose, a series of polymer composites was synthesized via the cross-linking of hyaluronate and a hyaluronate/polyacrylate mixture with Fe2O3 nanoparticles. The cross-linking imparts magnetic properties to the composites, which are more pronounced for the ternary hyaluronate/polyacrylate/γ-Fe2O3 composites compared with the binary hyaluronate/Fe2O3 composites. When dispersed in water, the composites produce microsized hydrogel particles. Circulation of the ternary microgels in an aqueous solution at a speed of 1.84 cm/s can be stopped using a permanent external magnet with a magnetic flux density of 400 T. The composite hydrogels can absorb the antitumor antibiotic doxorubicin (Dox); the resulting constructs show their cytotoxicity to tumor cells to be comparable to the cytotoxicity of Dox itself. The addition of the hyaluronidase enzyme induces degradation of the binary and ternary microgels down to smaller particles. This study presents prospectives for the preparation of magnetically controlled biodegradable polymer carriers for the encapsulation of bioactive substances.

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“…Polymers of various nature are used for the manufacturing magnetic nanocomposites depending on the scope of application – from polybutadiene, polystyrene, polymethylmetacrylate and other petroleum‐based polymers to biopolymers such as chitosan, alginate etc 25–28 . Polyvinyl alcohol (PVA) was chosen for present study because it is known as an auspicious material for diverse applications due to its remarkable properties: biocompatibility and biodegradability, non‐toxicity, high water solubility, thermal stability 29,30 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and properties of magnetite nanoparticles with peroxide‐containing polymer shell and nanocomposites based on them

Serdiuk

Shevchuk

Bukartyk

et al. 2021

J of Applied Polymer Sci

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Magnetite nanoparticles (Fe3O4 NPs) with peroxide‐containing polymer shell have been synthesized using the method of coprecipitation from the mixture solutions of Fe (II) and Fe (III) salts in the presence of peroxide‐containing copolymer (PCC). Polymer shell presence has been proved by elemental and complex thermal analysis. Synthesized Fe3O4 NPs possess superparamagnetic properties. Their specific saturation magnetization decreases gradually from 65 to 54 A·m2·kg−1 with increasing PCC concentration owing to the surface spin pinning effect caused by a polymer shell. The average sizes of Fe3O4 NPs estimated from the data of XRD analysis and magnetic measurements are in the range of 9–12 nm. The NP sizes determined by the DLS method lie in the range of 150–270 nm; this result is significantly larger than the sizes estimated by the two aforementioned methods evidencing a tendency for Fe3O4 NPs toward self‐association. Cross‐linked composite films based on polyvinyl alcohol have been obtained via radical curing initiated by the PCC shell of nanoparticles. The resulting composite films are magnetically sensitive films with rather high physico‐mechanical properties (tensile strength reaches 48–67 MPa and relative elongation – 4%–21% depending on cross‐linking degree), a priori non‐toxic and biocompatible, which makes them promising materials for various applications.

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Magneto-sensitive hybrid nanocomposites of water-soluble sodium alginate cross-linked with calcium ions and maghemite

Cited by 5 publications

References 46 publications

Doxorubicin Loaded Magnetosensitive Water‐Soluble Nanogel Based on NIPAM and Iron (3+) Containing Nanoparticles

Doxorubicin Loaded Magnetosensitive Water‐Soluble Nanogel Based on NIPAM and Iron (3+) Containing Nanoparticles

Magnetically Controlled Hyaluronic Acid–Maghemite Nanocomposites with Embedded Doxorubicin

Synthesis and properties of magnetite nanoparticles with peroxide‐containing polymer shell and nanocomposites based on them

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