Magnetocardiography and exercise testing: data acquisition and data processing

Abstract

16 healthy male subjects (17-25 years, medium 20 years) underwent magnetocardiography during physical exercise. A s p e c i . signal averaging technique was developed because the quality of the magnetic signals exceeded that of the elecb.ocardiograhic signals, particularly regarding baseline shifting. Signifiant ST segment displacements of the magnetic signal were found during a m i s e at a heart rate of 120 bpm ( p < 0.001). Whereas no signifiant ST segment changes were found in the electrocardiographic map, which consisted in an m a y of 16precordial electrodes, simultaneously recorded. The hypothesis that junctional ST segment displacements can be detected earlier with the magnetocardwgram is discussed.

Pharmacokinetic profile of a novel slow release preparation of molsidomine

“…in vitro and in vivo (x-axis timei, ~i,-o and y-axis tim% vitro)' A continuous, piecewise linear function was adjusted to the time points by a least squares method. The different slopes of this function describe different phases of absorption [6], Since the first slope of the polyphasic correlation came close to unity, the in vitro dissolution could be used as an input function to the body system, and the individual concentration/time-profiles could be predicted by convolution of this input function with the individual weighting functions [6], Pharmacokinetic calculations, adjustment of exponential functions and the deconvolution and convolution were carried out using the HOEREP-PC program [9] (Brockmeier D, unpublished data).…”