Magnetocephalography: a noninvasive alternative to the Wada procedure

Papanicolaou, Andrew C.; Simos, Panagiotis G.; Castillo, Eduardo M.; Breier, Joshua I.; Sarkari, Shirin; Pataraia, Ekaterina; Billingsley, Rebecca L.; Buchanan, Scott; Wheless, James W.; Maggio, Vijayalakshmi; Maggio, William W.

doi:10.3171/jns.2004.100.5.0867

Cited by 236 publications

(201 citation statements)

References 38 publications

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“…In TLE, studies using receptive language paradigms have focused on late activations (>200ms) that likely reflect sustained N400 effects. These studies have demonstrated a high concordance (approximately 90%) between MEG language lateralization and the IAP (69,(91)(92)(93)(94). Other investigators have used silent verb generation and picture naming tasks with comparable results (95,96).…”

Section: Megmentioning

confidence: 89%

The use of neuroimaging to study behavior in patients with epilepsy

McDonald¹

2008

Epilepsy & Behavior

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Structural and functional neuroimaging continue to play an increasing role in the presurgical evaluation of patients with epilepsy. In addition to their value for localizing the epileptogenic zone and eloquent cortex, neuroimaging is contributing to our understanding of mood comorbidity in epilepsy. Although the vast majority of research has focused on patients with temporal lobe epilepsy (TLE), neuroimaging studies of patients with frontal lobe epilepsy (FLE) and primary generalized epilepsy are increasing in number. In this review, structural and functional imaging modalities that have received considerable research attention in recent years are reviewed, along with an assessment of their strengths and limitations for understanding behavior in epilepsy. In addition, advances in multimodal imaging are discussed along with their potential application to the presurgical evaluation of patients with seizure disorders.

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Section: Megmentioning

confidence: 89%

The use of neuroimaging to study behavior in patients with epilepsy

McDonald¹

2008

Epilepsy & Behavior

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“…However, the most promising novel noninvasive methods include direct measures of physiological language activation. Some newer methods include event-related brain potentials [4] and whole-head magnetoencephalography [5][6][7]. The other alternative activation techniques are based on hemodynamic responses to language activation, such as functional transcranial Doppler [8], single-photon-emission computed tomography [9], positron emission tomography [10], near-infrared spectroscopic mapping [11], and functional magnetic resonance imaging [12].…”

Section: Introductionmentioning

confidence: 99%

Power spectral density changes and language lateralization during covert object naming tasks measured with high-density EEG recordings

Ramon

Holmes

Freeman

et al. 2009

Epilepsy & Behavior

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a b s t r a c tOur objective was to study changes in EEG time-domain power spectral density (PSDt) and localization of language areas during covert object naming tasks in human subjects with epilepsy. EEG data for subjects with epilepsy were acquired during the covert object naming tasks using a net of 256 electrodes. The trials required each subject to provide the names of common objects presented every 4 seconds on slides. Each trial comprised the 1.0 second before and 3.0 seconds after initial object presentation. PSDt values at baseline and during tasks were calculated in the h, a, b, low c, and high c bands. The spatial contour plots reveal that PSDt values during object naming were 10-20% higher than the baseline values for different bands. Language was lateralized to left frontal or temporal areas. In all cases, the Wada test disclosed language lateralization to the left hemisphere as well.

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“…This template of performing non-invasive MEG tests of language dominance in parallel with IAP tests (which patients were having regardless) in order to reach a conclusion regarding their suitability for surgical re-section became widely used in order to provide mounting evidence for the ability of MEG to be used as a pre-operative diagnostic tool. Papanicolaou et al (2004) measured signals in MEG from 100 epilepsy surgery candidates ranging from 8-56 years of age in response to a word recognition task. Single ECDs were used to model the activity and compute a laterality index.…”

Section: Early Epilepsy Researchmentioning

confidence: 99%