Buoyancy-assisted upward MHD flows and dynamical behaviors of flow channel insert (FCI) in the dual-coolant lead-lithium (DCLL) blanket are studied numerically. Based on our internally developed and validated solver, the dynamical behaviors of magneto-thermo-fluid-structure coupled multiphysical field are investigated. A large amplitude, low frequency, and quasiperiodic unsteady reverse flow at high Re (31000), high Gr (3.5×1011), and moderate magnetic field (0.7~1.7T) is found in the DCLL blanket. This intricate phenomenon has been discovered for the first time, representing a combination of separate experimental results from Melnikov et al. (2016) and Khanal and Lei (2012). In our study of this large amplitude, low frequency, and quasiperiodic unsteady reverse flows, the importance of the cold helium gas to the instability of fluid flow in the bulk region and the thermal conductivity of the FCI to convection structure and instability are first found and recognized. Additionally, we take into account the effects of the temperature field and flow field on structural deformation and mechanical behavior of FCI, and we have discovered several intriguing phenomena, such as (1) the stability of fluid flow in the bulk region depends on the strength of the heat source, the magnitude of the magnetic field, and thermal conductivity of FCI; (2) the instability and periodicity of the fluid flow are primarily related to the unsteady reverse flow, which rises up and falls down periodically in the bulk region; (3) the physical mechanism of unsteady flow influenced by reverse flow, pressure drop, and Lorentz force has been concluded. It has been discovered that the breakdown of a reverse flow vortex causes a rapid reduction in pressure drop. (4) To avoid this phenomenon in engineering, a phase map of unsteady and steady flows in the DCLL blanket has been created. (5) The quasiperiodic characteristics of solid (flow channel insert) affected by flow are found and analyzed.