Magnetoelastic Sensors

Single dose oral analgesics for acute postoperative pain in adults - an overview of Cochrane reviews

“…Despite years of use and research, however, the mechanisms of action of paracetamol are not fully understood. Paracetamol has previously been shown to have no significant e ects on COX-1 or COX-2 (Schwab 2003), but has been considered as a selective COX-2 inhibitor (Hinz 2008). Significant paracetamol-induced inhibition of prostaglandin production has been demonstrated in tissues in the brain, spleen, and lung Flower 1972).…”

Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults

“…Salicylic acid and phenazone were produced in a synthetic process in the late 1870s, and salicylic acid, phenazone, and phenacetin were available for the treatment of pain, fever, and inflammation by the turn of the 20th century. The past 60 years has seen the introduction of paracetamol (which is probably a weak NSAID (Hinz 2008)) followed by ibuprofen, diclofenac, and many others (Brune 2004). NSAIDs are used with the aim of providing anti-inflammatory, antipyretic, and analgesic e ects in acute and chronic conditions of pain and inflammation (Dwivedi 2015).…”