Magnetoencephalographic analysis of paroxysmal fast activity in patients with epileptic spasms

Sueda, Keitaro; Takeuchi, Fumiya; Shiraishi, Hiroaki; Nakane, Shingo; Sakurai, Kotaro; Yagyu, Kazuyori; Asahina, Naoko; Kohsaka, Shinobu; Saitoh, Shinji

doi:10.1016/j.eplepsyres.2012.09.001

Cited by 12 publications

(10 citation statements)

References 26 publications

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“…In addition, the subcommission recommends that pediatric epilepsy specialist units should have capabilities for functional imaging with positron emission tomography (PET) or single‐photon emission computed tomography (SPECT) for further evaluation of complex cases. Details of presurgical evaluations that are needed to determine if patients are suitable candidates for surgery are presented in Table 4,8–13 . Most individuals who meet the criteria for resection have a proven localized area causing epileptic seizures that can be removed surgically without causing functional compromise.…”

Section: The Surgical Evaluation For Patients With Lgsmentioning

confidence: 99%

“…reported successful surgical outcomes in patients with a predominantly focal MRI abnormality that was congenital or acquired early in life, although 30–100% of the epileptiform discharges were generalized or contralateral to the MRI abnormality. Magnetoencephalogram (MEG) may be an added tool in identifying a focal onset of paroxysmal fast activity associated with tonic seizures 12 …”

Section: The Surgical Evaluation For Patients With Lgsmentioning

confidence: 99%

“…Details of presurgical evaluations that are needed to determine if patients are suitable candidates for surgery are presented in Table 1. 4,[8][9][10][11][12][13] Most individuals who meet the criteria for resection have a proven localized area causing epileptic seizures that can be removed surgically without causing functional compromise. Such patients have responded inadequately to antiepileptic medications, as defined by failure to achieve adequate response to 2 tolerated and appropriately chosen antiepileptic drug (AED) schedules as well as failure to achieve sustained freedom from seizure.…”

Section: The Surgical Evaluation For Patients With Lgsmentioning

confidence: 99%

“…Magnetoencephalogram (MEG) may be an added tool in identifying a focal onset of paroxysmal fast activity associated with tonic seizures. 12 There are many supportive tests that may be utilized in the surgical evaluation of patients. These tests fall into 2 categories: (1) those that aid in localizing the region for resection (e.g., PET, SPECT, MEG, electrocorticography) and (2) those that help define eloquent cortex to minimize neurologic deficits related to surgery (e.g., Wada, functional MRI [fMRI], electrocorticography).…”

Section: The Surgical Evaluation For Patients With Lgsmentioning

confidence: 99%

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Surgical options for patients with Lennox‐Gastaut syndrome

Douglass

Salpekar

2014

Epilepsia

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SUMMARYDespite ongoing investigation into pharmacologic treatments for Lennox-Gastaut syndrome (LGS), outcomes for chronic administration of medications remain disappointing. In many instances LGS is treatment refractory, resulting in poor prognoses that include intellectual disability, persisting seizures, and psychiatric conditions. For patients with treatment resistance to other modalities for LGS, a further option is surgical intervention. Evaluation for surgery should involve interictal electroencephalogram (EEG), magnetic resonance imaging (MRI) analysis, and age-appropriate neuropsychological/developmental assessment. Resective surgery, where seizure foci are removed, successfully controls seizures in many cases, particularly where lesionectomy or lobar resections are appropriate. Recent studies of resective surgery on individuals with LGS show promising results, with a high percentage of patients having improved seizure control. Corpus callosotomy is a palliative surgical approach that aims at controlling potentially injurious seizures, for example, atonic or drop seizures, by preventing the bilateral spread of epileptic activity. Once associated with a high risk for morbidity and mortality, microsurgical techniques and surgery limited to the anterior region of the callosum have greatly diminished complications of corpus callosotomy surgery. Vagus nerve stimulation, another palliative procedure, offers rates of seizure improvement similar to those of corpus callosotomy, with the exception of atonic seizure for which corpus callosotomy may lead to a greater reduction. Recent advances in surgical techniques offer encouraging options for treatment of LGS.

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Section: The Surgical Evaluation For Patients With Lgsmentioning

confidence: 99%

Section: The Surgical Evaluation For Patients With Lgsmentioning

confidence: 99%

Section: The Surgical Evaluation For Patients With Lgsmentioning

confidence: 99%

Section: The Surgical Evaluation For Patients With Lgsmentioning

confidence: 99%

See 2 more Smart Citations

Surgical options for patients with Lennox‐Gastaut syndrome

Douglass

Salpekar

2014

Epilepsia

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“…MEG is helpful in determining seizure propagation and exploring seizure mechanisms. Sueda et al [112] evaluated propagation of fast paroxysmal activity in two patients (child and adult) with LGS and applied time-frequency analysis to the data of interest. The time-frequency analyses results were overlaid on a reconstructed three-dimensional MRI image.…”

Section: Megmentioning

confidence: 99%

Contributions of neuroimaging to understand childhood epileptic encephalopathies

Korostenskaja

Griškova-Bulanova

Lee³

et al. 2015

J Pediatr Epilepsy

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Childhood epileptic encephalopathies (CEE) are often characterized by abnormal brain development in which epileptic electrical discharges may contribute to cognitive deficits, behavioral disturbances, or psychomotor dysfunction. Electroencephalography (EEG) is the primary diagnostic imaging tool used by care providers in order to observe the aggressive paroxysmal activity that manifests from CEE. Though EEG is an effective diagnostic tool, it provides limited insight into the etiology and pathophysiology that can be obtained through other imaging techniques. The aim of this paper is to review current neuroimaging techniques, such as intracranial EEG, magnetoencephalography, functional magnetic resonance imaging, and positron emission tomography and discuss how they complement EEG findings and contribute to our understanding of CEE. In addition, we address the value of imaging techniques in defining and predicting cognitive changes in CEE.

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Childhood Epilepsy

Shiraishi¹

2016

Clinical Applications of Magnetoencephalography

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Magnetoencephalographic analysis of paroxysmal fast activity in patients with epileptic spasms

Cited by 12 publications

References 26 publications

Surgical options for patients with Lennox‐Gastaut syndrome

Surgical options for patients with Lennox‐Gastaut syndrome

Contributions of neuroimaging to understand childhood epileptic encephalopathies

Childhood Epilepsy

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