Magnetoencephalographic recordings of visual evoked brain activity in the human fetus

Eswaran, Hari; Wilson, James D.; Preißl, Hubert; Robinson, Stephen E.; Vrba, Jan; Murphy, P.; Rose, Douglas F.; Lowery, Curtis L.

doi:10.1016/s0140-6736(02)09905-1

Cited by 86 publications

(59 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This should provide additional information about neuro-development, particularly when compared to an auditory stimulus. It will also complement previous work on the response of the fetus and neonate to visual stimuli studying development [Johnson, 2002], behaviour (via fetal heart rate) [Kiuchi et al, 2000], and more recently MEG [Eswaran et al, 2002].…”

Section: Introductionmentioning

confidence: 64%

“…More recently, a magnetoencephalography study has recorded visual evoked brain activity in 4 out of 10 fetuses. No localisation within the fetal brain was reported [Eswaran et al, 2002].…”

Section: Figurementioning

confidence: 99%

“…The evaluation of fetal brain function should allow the characterisation of normal functional neurodevelopment and its disturbance in various pathologies. Until recently, the only methods available to assess fetal brain function in utero have been the indirect study of fetal heart rate responses [Vindla et al, 1997] and magnetoencephalography (MEG) [Blum et al, 1985;Eswaran et al, 2002]. Functional magnetic resonance imaging (fMRI) has become a well-established method for determining the patterns of brain activation following stimulus presentation in the adult.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fetal brain activity in response to a visual stimulus

Fulford

Vadeyar

Dodampahala

et al. 2003

Human Brain Mapping

103

View full text Add to dashboard Cite

Previous studies have demonstrated the use of functional magnetic resonance imaging (fMRI) to assess fetal brain activity. To extend these studies, a fetal fMRI experiment using a visual stimulus has been performed at 0.5 T. This used a block fMRI paradigm with a bright, constant-intensity light source being shone at the maternal abdomen for 8 sec followed by 16 sec of darkness. This was repeated typically 40 times on nine subjects all of whom were greater than 36 weeks gestational age. Of these, one could not be analysed due to motion, three did not show significant activation, and five showed significant activation (P < 0.0085). In all cases, activation was localised within the frontal cortex. Exact localisation was difficult but this may correspond to the frontal eye fields and dorsolateral prefontal cortex. In no cases was significant activation present within the occipital region as would have been expected and was observed in 2/8 adult subjects. Hum. Brain Mapping 20:239-245, 2003.

show abstract

Section: Introductionmentioning

confidence: 64%

“…More recently, a magnetoencephalography study has recorded visual evoked brain activity in 4 out of 10 fetuses. No localisation within the fetal brain was reported [Eswaran et al, 2002].…”

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fetal brain activity in response to a visual stimulus

Fulford

Vadeyar

Dodampahala

et al. 2003

Human Brain Mapping

103

View full text Add to dashboard Cite

show abstract

“…The latency of the fetal response falls with increasing gestational age and begins to approach the adult latency near term. 197 Recent experimental findings have demonstrated the importance of fetal eye motility in retinal (neuronal) cell differentiation, as well as eye functional maturation. 198 Fetal life in utero is organized in cyclical patterns.…”

Section: Fetal and Maternal Physiology And Ultrasound Diagnosismentioning

confidence: 99%

Fetal and Maternal Physiology and Ultrasound Diagnosis

Kadić¹,

Predojević²,

Kurjak³

et al. 2013

Donald School Journal of Ultrasound in Obstetrics and Gynecology

View full text Add to dashboard Cite

Fetal developmental potential is determined at the moment of conception by genetic inheritance. However, this development is modulated by environmental factors. It is important to recognize that both, the mother and the fetus, actively participate in the maintenance of the physiological intrauterine environment. Unfortunately, the fetus is not entirely protected from harmful influences of the external factors. By altering the intrauterine environment, these factors can have a long-term effect on fetal health.

show abstract

“…Fetal magnetoencephalography (fMEG) enables us to non-invasively record brain activity in utero [18]. Fetal brain activity has mainly been studied as evoked activity to visual [19] and auditory stimulation [20,21]. Response latencies to auditory stimuli decrease with fetal age and provide quantitative information on fetal functional brain maturation [22,23].…”

Section: Introductionmentioning

confidence: 99%

Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity

et al. 2014

Self Cite

View full text Add to dashboard Cite

Aims/hypothesis Fetal programming plays an important role in the pathogenesis of type 2 diabetes. The aim of the present study was to investigate whether maternal metabolic changes during OGTT influence fetal brain activity. Methods Thirteen healthy pregnant women underwent an OGTT (75 g). Insulin sensitivity was determined by glucose and insulin measurements at 0, 60 and 120 min. At each time point, fetal auditory evoked fields were recorded with a fetal magnetoencephalographic device and response latencies were determined. Results Maternal insulin increased from a fasting level of 67±25 pmol/l (mean ± SD) to 918±492 pmol/l 60 min after glucose ingestion and glucose levels increased from 4.4±0.3 to 7.4±1.1 mmol/l. Over the same time period, fetal response latencies decreased from 297±99 to 235±84 ms (p=0.01) and then remained stable until 120 min (235±84 vs 251±91 ms, p=0.39). There was a negative correlation between maternal insulin sensitivity and fetal response latencies 60 min after glucose ingestion (r=0.68, p=0.02). After a median split of the group based on maternal insulin sensitivity, fetuses of insulin-resistant mothers showed a slower response to auditory stimuli (283±79 ms) than those of insulin-sensitive mothers (178±46 ms, p=0.03). Conclusions/interpretation Lower maternal insulin sensitivity is associated with slower fetal brain responses. These findings provide the first evidence of a direct effect of maternal metabolism on fetal brain activity and suggest that central insulin resistance may be programmed during fetal development.

show abstract

Magnetoencephalographic recordings of visual evoked brain activity in the human fetus

Cited by 86 publications

References 4 publications

Fetal brain activity in response to a visual stimulus

Fetal brain activity in response to a visual stimulus

Fetal and Maternal Physiology and Ultrasound Diagnosis

Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity

Contact Info

Product

Resources

About