2017
DOI: 10.1016/j.seizure.2016.10.028
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Magnetoencephalography (MEG): Past, current and future perspectives for improved differentiation and treatment of epilepsies

Abstract: In addition to visual analysis digital computerized recording of electrical and magnetic fields by using EEG and MEG opened a new window for research concerning improved understanding of pathophysiology, diagnosis and treatment of epilepsies. In the last 25 years MEG was used more and more in clinical studies concerning localization of focal epileptic activity, functional cortex and network analysis. Simultaneous MEG/EEG recording and analysis offer the use of complimentary information increasing the sensitivi… Show more

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Cited by 45 publications
(35 citation statements)
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References 33 publications
(36 reference statements)
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“…during two main phases of the treatment [3,4]: first, localizing the region of the brain which produces the abnormal electrical activities that cause the neurological disorder. If the localized region is not responsible for a vital function in the brain such as speech, this region is usually extracted surgically if the medications were not effective for the treatment.…”
Section: Introductionmentioning
confidence: 99%
“…during two main phases of the treatment [3,4]: first, localizing the region of the brain which produces the abnormal electrical activities that cause the neurological disorder. If the localized region is not responsible for a vital function in the brain such as speech, this region is usually extracted surgically if the medications were not effective for the treatment.…”
Section: Introductionmentioning
confidence: 99%
“…Limitations of current studies include small sample size and selection bias (oftentimes highly preselected or otherwise unclear cases are referred to MEG). These restrictions could be addressed byprospective multicenterefforts with blinded outcome assessment [32]. Despite growing use worldwide, it is to be expected that not every epilepsy center will (or should) offer MEG.…”
Section: Discussionmentioning
confidence: 99%
“…Outcome strongly depends on the type of surgery and its location, with a chance of seizure freedom after 1 year of 66% for temporal lobe epilepsy, 46% for parietal and occipital lobe epilepsy, but only 27% in frontal lobe epilepsy [37]. Magnetoencephalography (MEG) or magnetic source imaging (MSI) is one of the newer additions to the presurgical work-up [32,38]. Source localization of the epileptogenic or irritative zone and functional mapping are the two main clinical applications.…”
Section: Introductionmentioning
confidence: 99%
“…Darüber hinaus sind auch 7 Tesla MRT-Scanner derzeit noch ausschließlich zu Forschungszwecken im Einsatz. Je nach Konstellation können auch ergänzende hochauflösende EEG-Untersuchungen und die Magnetenzephalografie (MEG) hilfreich sein [47,48], oder radioaktive bildgebende Methoden wie das Glukose-(FDG)-PET des Gehirns (zur Erfassung eines regionalen Hypometabolismus als Hinweis auf die Zone des funktionellen Defizits) und anfallsbezogene SPECT-Untersuchungen (zur Erfassung der iktualen regionalen Hyperperfusion als Hinweis auf die Anfallsursprungszone) erforderlich werden [49]. An manchen Standorten kommen mittlerweile auch weitere kombinierte Verfahren wie MRT/MEG (Magnetic Source Imaging = MSI) bzw.…”
Section: Erhöhte Vorzeitige Sterblichkeit Und Häufige Komorbiditätenunclassified