Magnetoencephalography reveals increased slow-to-fast alpha power ratios in patients with chronic pain

Witjes, Bart; Baillet, Sylvain; Roy, Mathieu; Oostenveld, Robert; Huygen, Frank; Vos, Cecile C de

doi:10.1097/pr9.0000000000000928

Cited by 18 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4b). We found that, compared to other receptors, the spatial distribution of MOR (opioid), H 3 (histamine) and α 4 β 2 make a large contribution to the fit between receptors and lower-frequency (theta and alpha) as well as low-gamma power bands 32,33 . Interestingly, we found a prominence of ionotropic receptors when we replicated the analysis in the autoradiography dataset (see the 'Replication using autoradiography' section and Supplementary Fig.…”

Section: Receptor Profiles Shape Oscillatory Neural Dynamicsmentioning

confidence: 84%

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

et al. 2022

Self Cite

View full text Add to dashboard Cite

Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.

show abstract

Section: Receptor Profiles Shape Oscillatory Neural Dynamicsmentioning

confidence: 84%

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Finally, 76 studies were included. 1 , 5 – 8 , 10 , 11 , 15 , 16 , 18 – 27 , 30 – 33 , 35 , 37 – 49 , 51 , 56 , 59 , 60 , 63 , 66 – 69 , 74 – 76 , 79 , 80 , 82 , 89 – 91 , 95 – 98 , 100 – 105 , 109 , 110 , 112 – 115 , 120 , 122 , 124 – 126 Figure 1 depicts the PRISMA flow diagram of study selection along with reasons for study exclusion at every stage.…”

Section: Resultsmentioning

confidence: 99%

Resting-state electroencephalography and magnetoencephalography as biomarkers of chronic pain: a systematic review

Zebhauser¹,

Hohn²,

Ploner³

2022

Pain

View full text Add to dashboard Cite

Reliable and objective biomarkers promise to improve the assessment and treatment of chronic pain. Resting-state electroencephalography (EEG) is broadly available, easy to use, and cost efficient and, therefore, appealing as a potential biomarker of chronic pain. However, results of EEG studies are heterogeneous. Therefore, we conducted a systematic review (PROSPERO CRD42021272622) of quantitative resting-state EEG and magnetoencephalography (MEG) studies in adult patients with different types of chronic pain. We excluded populations with severe psychiatric or neurologic comorbidity. Risk of bias was assessed using a modified Newcastle-Ottawa Scale. Semiquantitative data synthesis was conducted using modified albatross plots. We included 76 studies after searching MEDLINE, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and EMBASE. For cross-sectional studies that can serve to develop diagnostic biomarkers, we found higher theta and beta power in patients with chronic pain than in healthy participants. For longitudinal studies, which can yield monitoring and/or predictive biomarkers, we found no clear associations of pain relief with M/EEG measures. Similarly, descriptive studies that can yield diagnostic or monitoring biomarkers showed no clear correlations of pain intensity with M/EEG measures. Risk of bias was high in many studies and domains. Together, this systematic review synthesizes evidence on how resting-state M/EEG might serve as a diagnostic biomarker of chronic pain. Beyond, this review might help to guide future M/EEG studies on the development of pain biomarkers.

show abstract

“…Moreover, we visually observed a shift in the alpha and beta band peaks towards lower frequencies in patients with chronic pain (Supplementary Figure 2B, available at http://links.lww.com/PR9/A206), consistent with previous resting-state studies in chronic pain populations. 9,78,81 Despite this observation, independent nonparametric permutation Student t tests did not find significant differences in baseline signal power between the HC and CP groups. Additionally, there were no significant differences in peak frequencies nor total signal power in the alpha and beta frequency bands between the 2 groups.…”

Section: Resultsmentioning

confidence: 91%

Neurophysiological oscillatory markers of hypoalgesia in conditioned pain modulation

Jin,

Witjes,

Roy

et al. 2023

PR9

Self Cite

View full text Add to dashboard Cite

Introduction: Conditioned pain modulation (CPM) is an experimental procedure that consists of an ongoing noxious stimulus attenuating the pain perception caused by another noxious stimulus. A combination of the CPM paradigm with concurrent electrophysiological recordings can establish whether an association exists between experimentally modified pain perception and modulations of neural oscillations. Objectives: We aimed to characterize how CPM modifies pain perception and underlying neural oscillations. We also interrogated whether these perceptual and/or neurophysiological effects are distinct in patients affected by chronic pain. Methods: We presented noxious electrical stimuli to the right ankle before, during, and after CPM induced by an ice pack placed on the left forearm. Seventeen patients with chronic pain and 17 control participants rated the electrical pain in each experimental condition. We used magnetoencephalography to examine the anatomy-specific effects of CPM on the neural oscillatory responses to the electrical pain. Results: Regardless of the participant groups, CPM induced a reduction in subjective pain ratings and neural responses (beta-band [15–35 Hz] oscillations in the sensorimotor cortex) to electrical pain. Conclusion: Our findings of pain-induced beta-band activity may be associated with top-down modulations of pain, as reported in other perceptual modalities. Therefore, the reduced beta-band responses during CPM may indicate changes in top-down pain modulations.

show abstract

Magnetoencephalography reveals increased slow-to-fast alpha power ratios in patients with chronic pain

Abstract: Supplemental Digital Content is Available in the Text. We report an increased slow-to-fast alpha power ratio of neurophysiological activity in chronic pain from known pain-processing areas, among others.

Cited by 18 publications

References 35 publications

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Resting-state electroencephalography and magnetoencephalography as biomarkers of chronic pain: a systematic review

Neurophysiological oscillatory markers of hypoalgesia in conditioned pain modulation

Contact Info

Product

Resources

About